Inactivated bacterial cell formulation
View Patent ↗The invention relates to the use of lactic acid-producing bacteria to boost the immune system.
1. A method of enhancing an immune response to a microbial pathogen in a subject comprising:
identifying a subject infected with said microbial pathogen; and
administering to said subject a composition comprising purified cell wall components of a Bacillus coagulans bacterium in an amount that enhances said immune response.
2. The method of claim 1 , wherein said microbial pathogen is a bacterium or a virus.
3. The method of claim 1 , wherein said pathogen causes a viral respiratory infection.
4. The method of claim 1 , wherein said pathogen comprises an influenza virus.
5. The method of claim 1 , wherein said pathogen comprises a human, an avian, or a swine influenza virus, or a combination thereof.
6. The method of claim 1 , wherein said pathogen comprises an adenovirus.
7. The method of claim 1 , wherein enhancement of said immune response comprises an increase in cytokine production or an increase in immune cell migration to an infection site.
8. The method of claim 7 , wherein said cytokine comprises interleukin-2 (IL-2), IL-4, IL-6, IL-10, tumor necrosis factor-α (TNF-α), or interferon-γ (IFN-γ).
9. The method of claim 1 , wherein enhancement of said immune response comprises increasing cytokine production, activating immune surveillance aspect of polymorphonuclear leukocytes (PMN), increasing immune cell chemotaxis, activating natural killer (NK) cells, or increasing monocyte phagocytosis.
10. The method of claim 9 , wherein enhancement of said immune response comprises increased phagocytosis or chemotaxis by said PMNs.
11. The method of claim 9 , wherein enhancement of said immune response comprises increased expression of CD69 on said NK cells.
12. The method of claim 1 , wherein said Bacillus coagulans is Bacillus coagulans hammer strain Accession No. ATCC 31284 or a strain derived from Bacillus coagulans hammer strain Accession No. ATCC 31284.
13. The method of claim 1 , wherein said Bacillus coagulans is selected from the group consisting of GBI-30 strain (ATCC Designation Number PTA-6086), GBI-20 strain (ATCC Designation Number PTA-6085), and GBI-40 strain (ATCC Designation Number PTA-6087).