IP Library Granted Patent US 8,231,912
Granted Patent B2
US 8,231,912 · App. 12/771,246 · Granted Jul 31, 2012

Cleanser composition and methods for using the same

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Quick Facts
Patent No.
US 8,231,912
App. No.
12/771,246
Granted
Jul 31, 2012
Kind
B2
Abstract

The present invention is directed to anti-microbial cleanser compositions comprising linalool, hinokitiol and dipropylene glycol. The present invention further provides methods for using these compositions to maintain eyelid hygiene, to treat an ocular disorder or to clean a skin surface. The cleanser compositions of the present invention can be in the form of a foam, gel or liquid.

Claims (99)

1. A cleanser composition suitable for application to the skin and ocular surface comprising the following components in approximately the following concentrations as a percent by weight of the composition:

(a)

a blend of PEG-80, sorbitan laurate, sodium

0.5-10.0%;

trideceth sulfate, cocamidopropyl betaine,

sodium lauroamphoacetate, PEG-150 distearate,

and sodium laureth-13 carboxylate

(b)

Decyl Glucoside

0.2-10.0%;

(c)

Linalool

0.5-2.0%;

(d)

Cocamidopropyl PG-Dimonium Chloride

0.01-5.0%;

Phosphate

(e)

Trisodium EDTA

0.01-1.0%;

(f)

Allantoin

0.01-1.0%;

(g)

Panthenol

0.01-1.0%;

(h)

Hinokitiol

0.01-5.0%;

(i)

Tea Tree Oil

0.005-2.0%;

(j)

Vitamin E Acetate

0.005-2.0%;

(k)

Water

0.0-98.15%;

(l)

Dipropylene glycol

1.0-50.0%;

and

(m)

Cocamidopropyl betaine

0.1-20.0%.

2. The cleanser composition of claim 1 , wherein the cleanser composition is a applied as a foam, gel or liquid.

3. The cleanser composition of claim 1 , wherein the composition is for the treatment of an ocular disorder.

4. The cleanser composition of claim 3 , wherein the ocular disorder is dry eye, excessive bacteria on the eyelid dermis, Meibomian gland dysfunction (MGD), blepharitis, acne rosacea, scalp dandruff, seborrheic dermatitis, chalazion, hordeolum, sty infectious conjunctivitis, corneal ulcer, or demodex infestation.

5. The cleanser composition of claim 1 , wherein the ocular disorder is anterior or posterior blepharatis.

6. The cleanser composition of claim 1 , wherein the composition is effective against at least one of the following microorganisms: S. aureus, P. aeruginosa , B. catarrhalis, E. coli, S. marcescens, S. epidermidis , MRSA, and P. ovale.

7. The cleanser composition of claim 6 , wherein the S. aureus is methicillin resistant S. aureus.

8. The cleanser composition of claim 1 , wherein the cleanser composition is suitable for direct application to the ocular surface, an eyelid or the skin surrounding the eyelid of a subject.

9. The cleanser composition of claim 1 , wherein the cleanser comprises the following components in approximately the following amounts as a percent by weight of the composition:

(a)

a blend of PEG-80, sorbitan laurate, sodium

3.8%;

trideceth sulfate, cocamidopropyl betaine,

sodium lauroamphoacetate, PEG-150 distearate,

and sodium laureth-13 carboxylate

(b)

Decyl Glucoside

1.7% 

(c)

Linalool

0.9%;

(d)

Cocamidopropyl PG-Dimonium Choloride

0.2%;

Phosphate

(e)

Trisodium EDTA

0.1%;

(f)

Allantoin

0.1%;

(g)

Panthenol

0.1% 

(h)

Hinokitiol

0.05%;

(i)

Tea Tree Oil

0.025%;

(j)

Vitamin E Acetate

0.01%;

(k)

Water

68.215%;

(l)

Dipropylene glycol

23.0%;

and

(m)

Cocamidopropyl betaine

2.0%.

10. The cleanser composition of claim 1 , wherein the pH range is about 4.5-6.0.

11. The cleanser composition of claim 1 , wherein the pH range is about 5.3-5.7.

Assignments (23)
SECURITY INTEREST Recorded Jul 24, 2026
From: MEDTECH PRODUCTS INC.; INSIGHT PHARMACEUTICALS CORPORATION; DENTEK ORAL CARE, INC.
To: CITIBANK, N.A., AS ADMINISTRATIVE AGENT
Reel/Frame 075392/0725 →
RELEASE OF SECURITY INTEREST IN CERTAIN PATENTS @ REELS AND FRAMES: 053954/0755 AND 053955/0060 Recorded Jul 7, 2023
From: WILMINGTON SAVINGS FUND SOCIETY, FSB, AS ADMINISTRATIVE AGENT
To: AKORN OPERATING COMPANY LLC
Reel/Frame 064234/0872 →
CORRECTION BY DECLARATION TO CORRECT THE 10 ERRONEOUSLY NULLIFIED PROPERTIES ON COVER SHEET AT REEL 057970 FRAME 0475. ASSIGNOR HEREBY CONFIRMS THAT THE 10 PROPERTIES LISTED THERE AND HEREIN SHOULD NOT HAVE BEEN NULLIFIED. Recorded Nov 12, 2021
From: AKORN OPERATING COMPANY LLC
To: MEDTECH PRODUCTS INC.
Reel/Frame 058104/0741 →
CORRECTION BY NULLIFICATION TO CORRECT INCORRECTLY RECORDED PROPERTY NUMBERS AT REEL/FRAME 57222/0489. ASSIGNOR HEREBY CONFIRMS THE ASSIGNMENT. Recorded Oct 25, 2021
From: AKORN OPERATING COMPANY LLC
To: MEDTECH PRODUCTS INC.
Reel/Frame 057970/0475 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 18, 2021
From: AKORN OPERATING COMPANY LLC
To: MEDTECH PRODUCTS INC.
Reel/Frame 057222/0489 →
RELEASE OF SECURITY INTEREST Recorded Jul 8, 2021
From: WILMINGTON SAVINGS FUND SOCIETY, FSB
To: AKORN, INC.; AKORN INTERMEDIATE COMPANY LLC; AKORN OPERATING COMPANY, LLC
Reel/Frame 056794/0730 →
RELEASE OF SECURITY INTEREST Recorded Jul 8, 2021
From: MIDCAP FUNDING IV TRUST
To: AKORN OPERATING COMPANY, LLC
Reel/Frame 056794/0811 →
RELEASE OF SECURITY INTEREST RECORDED AT 032714/0440 Recorded May 10, 2021
From: WILMINGTON SAVINGS FUND SOCIETY, FSB
To: ADVANCED VISION RESEARCH, INC.
Reel/Frame 056194/0806 →
RELEASE OF SECURITY INTEREST RECORDED AT REEL/FRAME 052753/0356 Recorded May 3, 2021
From: WILMINGTON SAVINGS FUND SOCIETY, FSB
To: ADVANCED VISION RESEARCH, INC.
Reel/Frame 056122/0720 →
RELEASE OF SECURITY INTEREST RECORDED AT REEL/FRAME 032714/0411 Recorded Mar 29, 2021
From: JPMORGAN CHASE BANK, N.A.
To: ADVANCED VISION RESEARCH, INC.
Reel/Frame 055759/0646 →
ENTITY CONVERSION Recorded Feb 8, 2021
From: ADVANCED VISION RESEARCH, INC.
To: ADVANCED VISION RESEARCH, LLC
Reel/Frame 055257/0224 →
CORRECTIVE ASSIGNMENT TO CORRECT THE SCHEDULE OF PATENT APPLICATIONS AND GRANTED PATENTS TO BE ASSIGNED TO AKORN OPERATING COMPANY LLC PREVIOUSLY RECORDED ON REEL 054202 FRAME 0382. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Dec 1, 2020
From: AKORN, INC.; ADVANCED VISION RESEARCH, LLC; HI-TECH PHARMACAL CO., LLC
To: AKORN OPERATING COMPANY, LLC
Reel/Frame 055326/0694 →
CONFIRMATORY GRANT OF SECURITY INTEREST IN UNITED STATES PATENTS Recorded Nov 5, 2020
From: AKORN OPERATING COMPANY LLC
To: MIDCAP FUNDING IV TRUST
Reel/Frame 054333/0247 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 28, 2020
From: AKORN, INC.; ADVANCED VISION RESEARCH, LLC; HI-TECH PHARMACAL CO., LLC
To: AKORN OPERATING COMPANY, LLC
Reel/Frame 054202/0382 →
SECURITY INTEREST Recorded Oct 1, 2020
From: AKORN OPERATING COMPANY LLC
To: WILMINGTON SAVINGS FUND SOCIETY, FSB
Reel/Frame 053954/0755 →
SECURITY INTEREST Recorded Oct 1, 2020
From: AKORN OPERATING COMPANY LLC
To: WILMINGTON SAVINGS FUND SOCIETY, FSB
Reel/Frame 053955/0060 →
SECURITY INTEREST Recorded May 26, 2020
From: ADVANCED VISION RESEARCH, INC.
To: WILMINGTON SAVINGS FUND SOCIETY, FSB
Reel/Frame 052753/0356 →
SECURITY INTEREST Recorded Apr 1, 2020
From: JPMORGAN CHASE BANK, N.A., AS RESIGNING ADMINISTRATIVE AGENT
To: WILMINGTON SAVINGS FUND SOCIETY, FSB, AS SUCCESSOR ADMINISTRATIVE AGENT
Reel/Frame 052284/0618 →
RELEASE OF SECURITY INTEREST Recorded Apr 18, 2014
From: BANK OF AMERICA N.A., AS AGENT
To: AKORN, INC.; ADVANCED VISION RESEARCH, INC.
Reel/Frame 032710/0037 →
SECURITY INTEREST (ABL) Recorded Apr 18, 2014
From: ADVANCED VISION RESEARCH, INC.
To: JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT
Reel/Frame 032714/0411 →
SECURITY INTEREST (TERM LOAN) Recorded Apr 18, 2014
From: ADVANCED VISION RESEARCH, INC.
To: JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT
Reel/Frame 032714/0440 →
SECURITY AGREEMENT Recorded Oct 13, 2011
From: AKORN, INC.; ADVANCED VISION RESEARCH, INC.
To: BANK OF AMERICA, N.A., AS AGENT
Reel/Frame 027059/0798 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 22, 2010
From: GILBARD, JEFFREY P.; DOUYON, YANICK; HUSON, ROBERT B.
To: ADVANCED VISION RESEARCH, INC.
Reel/Frame 024725/0824 →