COATING OF COMPLEXED ACTIVES IN FILM FORMULATIONS
The present invention relates to products and methods of making products having a dual taste masked active component. In particular, the present invention relates to film dosage forms including at least one dual taste masked active, where the dual taste masked active includes a coated complexed active composition.
1 . A self-supporting film dosage composition comprising: a complex of an active and a complexing agent; and an ingestible polymer at least partially coating said complex.
2 . The composition of claim 1 , wherein said complexing agent comprises an ion exchange resin.
3 . The composition of claim 1 , wherein said coated complexed active comprises a particle.
4 . The composition of claim 3 , wherein said particle has a particle size of about 10 to about 200 microns.
5 . A method of making a self-supporting film dosage composition comprising the steps of:
a. complexing an active with a complexing agent to form a complexed active;
b. at least partially coating said complexed active with a polymeric coating to form an at least partially coated complexed active;
c. dispersing a therapeutically effective amount of said coated complexed active into a film-forming polymeric matrix to form an active matrix; and
d. drying said active matrix to form a self-supporting film dosage composition.
6 . The method of claim 5 , wherein said complexing agent comprises an ion exchange resin.
7 . The method of claim 5 , wherein said coated complexed active comprises a particle.
8 . The method of claim 7 , wherein said particle has a particle size of about 10 to about 200 microns.
9 . A method of taste masking an active composition, comprising the steps of:
a. complexing an active with a complexing agent to form a complexed active; and
b. at least partially coating said complexed active with a polymeric coating to form an at least partially coated complexed active.
10 . The method of claim 9 , wherein said complexing agent comprises an ion exchange resin.
11 . The method of claim 9 , wherein said coated complexed active comprises a particle.
12 . The method of claim 11 , wherein said particle has a particle size of about 10 to about 200 microns.