Percutaneous method and device to treat dissections
View Patent ↗Some embodiments are directed to methods and systems for percutaneously treating dissections in a patient's vasculature, such as, without limitation, the aorta. The method can include deploying a catheter containing a collapsed anchoring element, frame, and cover through a first vessel to an entry point of the dissection. The anchoring element can be secured to the second branch vessel. The frame can be expanded in the first branch vessel. The cover can be unfolded over at least a portion of the entry point. The cover then reduces blood flow into the entry point.
1. A device for treating a vascular dissection, comprising:
an anchor that can be deployed in a branch lumen connected to a frame having a first elliptical element and a second elliptical element connected together at a pair of connection points, the first and second elliptical elements being configured to form an open cage in a deployed state, wherein the first frame lies within a first plane extending through a major axis of the first elliptical element that intersects with a second plane in which the second frame lies and the second plane extending through a major axis of the second elliptical element, the intersection of the two planes dividing the first elliptical element into a first half and a second half and the second elliptical element into a first half and a second half; and
a cover conforming to an edge of the first half of the first elliptical element and extending to an edge of the first half of the second elliptical element, the cover comprising an outer periphery of the frame, a first portion of the outer periphery being configured to conform to a radial portion of the first half of the second elliptical element, the cover extending to the connection points between the first and second elliptical elements,
wherein the frame is configured to unfold the cover during deployment of the frame.
2. The device of claim 1 , wherein the anchor and the cover are collapsible into a first collapsed state for positioning within a catheter and are expandable to a second expanded state.
3. The device of claim 1 , wherein the anchor, the frame, and the cover are collapsible into a first collapsed state for positioning within a catheter and expandable to a second expanded state.
4. The device of claim 1 , wherein the cover is attached to the frame using sutures or adhesive.
5. The device of claim 1 , wherein the frame comprises a memory material such as Nitinol.
6. The device of claim 1 , wherein the cover comprises at least one of a protein matrix, polyester, ePTFE, polyurethane, silk, and animal tissue.
7. The device of claim 6 , wherein the protein matrix comprises at least one of mammalian tissue, collagen, elastin, fibrin, polysaccharides such as chitosan or glycosaminoglycans, and a cross-linking agent.
8. The device of claim 7 , wherein the cross-linking agents comprise at least one of glutaraldehydes, carbodiimide, tannins, polyphenols, and photo-activated cross-linking agents.
9. The device of claim 7 , wherein the mammalian tissue comprises tissue harvested from pericardium, small intestine submucosa, blood vessels, or skin.
10. The device of claim 1 , wherein the anchor is a stent.
11. The device of claim 1 , wherein the anchor comprises at least one of a coil, hook, barb, balloon, stent graft, screw, or staple.
12. The device of claim 1 , wherein the cover is configured to contact at least a portion of a main lumen.
13. The device of claim 1 , wherein a thickness of the cover is between approximately 0.0001 inches and approximately 0.01 inches.
14. The device of claim 1 , wherein a second portion of the outer periphery is configured to conform to a radial portion of the second elliptical element.
15. The device of claim 14 , wherein the first portion of the outer periphery is configured to attach to the first elliptical element and the second portion of the outer periphery is configured to attach to the second elliptical element.
16. The device of claim 14 , wherein the first portion and the second portion form the entire outer periphery of the cover.
17. The device of claim 16 , wherein the first portion of the outer periphery is configured to attach to the first elliptical element and the second portion of the outer periphery is configured to attach to the second elliptical element.
18. The device of claim 16 , wherein the outer periphery of the cover is configured to conform to one-half of the frame.
19. A device for treating a vascular dissection, comprising:
an anchor that can be deployed in a branch lumen connected to a frame having a first elliptical element and a second elliptical element connected together at two connections that divide each of the elliptical elements into a first part and a second part, the first and second elliptical elements being configured to form an open cage in a deployed state; and
a cover extending from the first part of the first elliptical element to the second part of the second elliptical element, the cover comprising an outer periphery, a first portion of the outer periphery being configured to conform to a radial portion of the first part of the first elliptical element and a second portion of the outer periphery being configured to conform to a radial portion of the second part of the second elliptical element, the cover extending to the connection points;
wherein the anchor is connected to the frame by a connecting structure extending from a single location on the anchor to a single location on the frame.
20. The device of claim 19 , wherein a first plane extending through a major axis of the first elliptical element intersects a second plane extending through a major axis of the second elliptical element.
21. The device of claim 19 , wherein the frame is configured to unfold the cover during deployment of the frame.