Tracers for cationic amino acid transport systems and methods of synthesis are disclosed, including compounds comprising a 1H-[1,2,3]triazole moiety. Further disclosed are uses of the analogues, including in vivo imaging of tumors by Positron emission tomography (PET) or Single Photon Emission Computed Tomography (SPECT).
1. A 1H-[1,2,3]triazole substituted amino acid of structure
wherein R 1 is CH 2 or O, n is an integer from 0 to 3, m is an integer from 0 to 1, and p is an integer from 0 to 1 wherein F is 18 F.
2. A 1H-[1,2,3]triazole substituted amino acid in accordance with claim 1 , wherein R 1 is CH 2 , n is from 1 to 3, m is 0, p is 1, and F is an 18 F.
3. A 1H-[1,2,3]triazole substituted amino acid in accordance with claim 1 , wherein R 1 is CH 2 , n is l, m is 0, p is 1, and F is an 18 F.
4. A 1H-[1,2,3]triazole substituted amino acid in accordance with claim 1 , wherein R 1 is CH 2 , n is 2, m is 0, p is 1, and F is an 18 F.
5. A 1H-[1,2,3]triazole substituted amino acid in accordance with claim 1 , wherein R 1 is CH 2 , n is 3, m is 0, p is 1, and F is an 18 F.
6. A 1H-[1,2,3]triazole substituted amino acid or salt thereof in accordance with claim 1 , wherein the acid is selected from the group consisting of
7. A 1H-[1,2,3]triazole substituted amino acid of structure
wherein R 2 is CH 2 or O, z is an integer from 0 to 3, y is an integer from 0 to 1, and x is an integer from 0 to 2 wherein F is 18 F.
8. A 1H-[1,2,3]triazole substituted amino acid in accordance with claim 7 , wherein R 2 is O, z is 1 to 3, y is 1, x is 2, and the F is an 18 F.
9. A 1H-[1,2,3]triazole substituted amino acid in accordance with claim 7 , wherein R 2 is O, z is 1, y is 1, x is 2, and the F is an 18 F.
10. A 1H-[1,2,3]triazole substituted amino acid in accordance with claim 7 , wherein R 2 is O, z is 2, y is 1, x is 2, and the F is an 18 F.
11. A 1H-[1,2,3]triazole substituted amino acid in accordance with claim 7 , wherein R 2 is O, z is 3, y is 1, x is 2, and the F is an 18 F.
12. A 1H-[1,2,3]triazole substituted amino acid in accordance with claim 7 , wherein the acid is selected from the group consisting of
13. A method of imaging a tumor in a mammal, the method comprising:
administering to the mammal a 1H-[1,2,3]triazole substituted amino acid of claim 1 ; and subjecting the mammal to PET scanning.
14. A method of imaging a tumor in a mammal in accordance with claim 13 , wherein the 1H-[1,2,3]triazole substituted amino acid is selected from the group consisting of
15. A method of imaging a tumor in a mammal in accordance with claim 13 , wherein the 1H-[1,2,3]triazole substituted amino acid is selected from the group consisting of