Apoptosis promoters
View Patent ↗Compounds which inhibit the activity of anti-apoptotic family protein members, compositions containing the compounds and methods of treating diseases during which occur expression one or more than one of an anti-apoptotic family protein member are disclosed.
1. A composition suitable for oral administration comprising an excipient and a compound having formula (II)
or a therapeutically acceptable salt thereof,
wherein
X 3 is Cl or F;
X 4 is azepan-1-yl, morpholin-1-yl, 1,4-oxazepan-4-yl, pyrrolidin-1-yl, N(CH 3 ) 2 , N(CH 3 )(CH(CH 3 ) 2 ), 7-azabicyclo[2.2.1]heptan-1-yl or 2-oxa-5-azabicyclo[2.2.1]hept-5-yl, and R 0 is
wherein
X 5 is CH 2 , C(CH 3 ) 2 or CH 2 CH 2 ;
X 6 and X 7 are both hydrogen or are both methyl; and
X 8 is F, Cl, Br or I.
2. The composition of claim 1 , wherein
X 5 is C(CH 3 ) 2 ; and
X 6 and X 7 are both hydrogen.
3. The composition of claim 1 or claim 2 , wherein X 4 is morpholin-1-yl.
4. A composition suitable for oral administration comprising an excipient and N-(4-(4-((2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohex-1-en-1-yl)methyl)piperazine-1-yl)benzoyl)-4-(((1R)-3-(morpholin-4-yl)-1-((phenylsulfanyl)methyl)propyl)amino)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide or a therapeutically acceptable salt thereof.