Solid support for Fmoc-solid phase synthesis of peptide acids
View Patent ↗The present invention provides a solid support for Fmoc-solid phase synthesis of peptides. In particular, the solid supports of the invention may be utilized to produce peptide acids.
1. A compound of Formula (I):
wherein:
R 1 is OR 8 ;
R 3 , R 5 , and R 6 are independently selected from the group consisting of hydrogen, hydrocarbyl, and substituted hydrocarbyl;
R 2 and R 4 are each {—}(CH 2 ) s CH 3 , wherein s is an integer from 0 to 5;
R 7 and the phenyl ring to which it is attached together comprise a solid support comprising at least one polymer;
R 8 is selected from the group consisting of hydrogen, a protecting group, an amino acid residue, a hydrocarbyl, a substituted hydrocarbyl, and a peptide; and
n and m are independently integers from 0 to 5.
2. The compound of claim 1 , wherein R 3 , R 5 , and R 6 are each hydrogen.
3. A compound of Formula (I):
wherein:
R 1 is OR 8 ;
R 2 , R 3 , and R 5 are independently selected from the group consisting of hydrogen, hydrocarbyl, and substituted hydrocarbyl;
R 4 and R 6 are each {—}(CH 2 ) s CH 3 , wherein s is an integer from 0 to 5;
R 7 and the phenyl ring to which it is attached together comprise a solid support comprising at least one polymer;
R 8 is selected from the group consisting of hydrogen, a protecting group, an amino acid residue, a hydrocarbyl, a substituted hydrocarbyl, and a peptide; and
n and m are independently integers from 0 to 5.
4. The compound of claim 3 , wherein R 2 , R 3 , and R 6 are each hydrogen.
5. A compound comprising Formula (I):
wherein:
R 1 is OR 8 ;
R 2 , R 3 , R 4 , R 5 , and R 6 are independently selected from the group consisting of hydrogen and hydrocarbyl, provided, however, that at least two of R 2 , R 3 , R 4 , R 5 , and R 6 are other than hydrogen;
R 7 and the phenyl ring to which it is attached together comprise a solid support comprising at least one polymer;
R 8 is selected from the group consisting of hydrogen, a protecting group, an amino acid residue, a hydrocarbyl, a substituted hydrocarbyl, and a peptide; and
n and m are independently integers from 0 to 5.
6. The compound of claim 5 comprising the following structure:
wherein R 7 is as defined in claim 5 .