IMMUNE RESPONSE INDUCTION METHOD
The present invention proposes a method of inducing both vaccine antigen-specific antibody in blood and vaccine antigen-specific antibody secreted at the mucosal surface using vaccine antigen and adjuvant of said vaccine antigen.
1 . A method of inducing both vaccine antigen-specific antibody in blood and vaccine antigen-specific antibody secreted at the mucosal surface using vaccine antigen and adjuvant of this vaccine antigen, comprising
(1) mucosal administration of vaccine antigen,
(2) the use of an interferon α as the active ingredient of the adjuvant,
(3) administration of said adjuvant at the same time as or at a different time than said vaccine antigen, and
(4) mucosal administration of said adjuvant by the same administration route as said vaccine antigen.
2 . The method according to claim 1 , wherein the interferon α is selected from natural interferons a and recombinant interferons α.
3 . The method according to claim 2 , wherein the amount of interferon α used is 0.5 to 5,000,000 IU.
4 . The method according to claim 2 , wherein the vaccine antigen is protein or peptide antigen.
5 . The method according to claim 2 , wherein mucosal administration is performed at the same time.
6 . The method according to claim 5 , wherein administration is via the nasal mucous membrane.