Solid forms and process for preparing
View Patent ↗The present invention provides amorphous solid forms of the compound of Formula I, as well as methods for preparing the compound of Formula I by precipitation.
1. Amorphous solid form of a compound of Formula I:
2. The amorphous solid form of claim 1 , characterized by an X-ray diffraction pattern, substantially as depicted in FIG. 1 .
3. A method of preparing an amorphous solid form of a compound of Formula I:
the method comprising:
dissolving the compound of Formula I in a solvent selected from the group consisting of acetone, methanol, ethanol, 2-propanol and 2-methoxyethanol, to prepare a first solution; and
contacting the first solution with water, thereby precipitating the compound of Formula I.
4. The method of claim 3 , wherein the solvent is selected from the group consisting of methanol, ethanol, 2-propanol and 2-methoxyethanol.
5. The method of claim 4 , wherein the solvent is selected from the group consisting of methanol, ethanol, and 2-propanol.
6. The method of claim 5 , wherein the solvent is ethanol.
7. The method of claim 6 , wherein the first solution is added to the water.
8. The method of claim 3 , wherein the ratio of solvent to water is from about 5:1 to about 1:10(vol/vol).
9. The method of claim 8 , wherein the ratio of solvent to water is from about 2:1 to about 1:2(vol/vol).
10. The method of claim 8 , wherein the ratio of solvent to water is about 1:1(vol/vol).
11. The method of claim 8 , wherein the ratio of solvent to water is from about 1:1 to about 1:5(vol/vol).
12. A method of preparing an amorphous solid form of a compound of Formula I:
the method comprising:
dissolving the compound of Formula I in 1,4-dioxane, to prepare a first solution; and
contacting the first solution with heptane, thereby precipitating the compound of Formula I.
13. A method of preparing an amorphous solid form of a compound of Formula I:
the method comprising:
dissolving the compound of Formula I in tert-butylmethyl ether, to prepare a first solution; and
contacting the first solution with heptane, to prepare a second solution; and
cooling the second solution to less than about 0° C., thereby precipitating the compound of Formula I.