IP Library Granted Patent US 8,768,028
Granted Patent B2
US 8,768,028 · App. 12/777,859 · Granted Jul 1, 2014

Methods and compositions for articular repair

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Quick Facts
Patent No.
US 8,768,028
App. No.
12/777,859
Granted
Jul 1, 2014
Kind
B2
Abstract

Disclosed herein are methods and compositions for producing articular repair materials and for repairing an articular surface. In particular, methods for providing articular repair systems. Also provided are articular surface repair systems designed to replace a selected area cartilage, for example, and surgical tools for repairing articular surfaces.

Claims (53)

1. A method of manufacturing a surgical instrument for the repair of a diseased articular joint surface, comprising:

obtaining electronic image data of the diseased articular joint surface;

shaping an inner surface of the surgical instrument based on a curvature of the diseased articular joint surface derived from the electronic image data; and

including a slit in the surgical instrument to define a cutting path through at least a portion of the joint when the inner surface is applied to the diseased articular joint surface.

2. The method of claim 1 , wherein the step of shaping the inner surface of the surgical instrument further comprises matching a shape of the inner surface of the surgical instrument to a curvature of the articular joint surface.

3. The method of claim 1 , wherein the step of shaping the inner surface of the surgical instrument further comprises matching a shape of the surgical instrument to a shape of the diseased articular joint surface.

4. The method of claim 1 , further comprising shaping the surgical instrument based at least in part on a size of the diseased articular joint surface.

5. The method of claim 1 , further comprising shaping the surgical instrument based at least in part on a size of diseased cartilage of the diseased articular joint surface.

6. The method of claim 1 , further comprising shaping the surgical instrument based at least in part on a curvature of diseased cartilage of the diseased articular joint surface.

7. The method of claim 1 , further comprising shaping the surgical instrument based at least in part on a shape of diseased cartilage of the diseased articular joint surface.

8. The method of claim 1 , further comprising shaping the surgical instrument based at least in part on a curvature of subchondral bone of the diseased articular joint surface.

9. The method of claim 1 , further comprising shaping the surgical instrument based at least in part on a shape of subchondral bone of the diseased articular joint surface.

10. The method of claim 1 , further comprising shaping the surgical instrument based at least in part on a curvature of subchondral bone underlying diseased cartilage of the diseased articular joint surface.

11. The method of claim 1 , wherein the image data includes image data of cartilage of the diseased articular joint surface.

12. The method of claim 1 , wherein the image data includes image data of subchondral bone of the diseased articular joint surface.

13. A method of manufacturing a surgical instrument for the repair of a diseased or damaged cartilage surface of a joint, comprising:

obtaining electronic image data of the diseased or damaged cartilage surface;

shaping an inner surface of the surgical instrument based at least in part on a curvature of the diseased or damaged cartilage surface derived from the electronic image data; and

including a slit in the surgical instrument to define a cutting path through at least a portion of the joint when the inner surface is applied to the diseased or damaged cartilage surface.

14. The method of claim 13 , wherein the step of shaping the inner surface of the surgical instrument further comprises matching a shape of the inner surface of the surgical instrument to a curvature of the diseased or damaged cartilage surface.

15. The method of claim 13 , wherein the step of shaping the inner surface of the surgical instrument further comprises matching a shape of the surgical instrument to a shape of the diseased or damaged cartilage surface.

16. The method of claim 13 , further comprising shaping the surgical instrument based at least in part on a size of the diseased or damaged cartilage surface.

17. The method of claim 13 , further comprising shaping the surgical instrument based at least in part on a shape of the diseased or damaged cartilage surface.

18. The method of claim 13 , further comprising shaping the surgical instrument based at least in part on a curvature of subchondral bone underlying the diseased or damaged cartilage surface.

19. The method of claim 13 , further comprising shaping the surgical instrument based at least in part on a shape of subchondral bone underlying the diseased or damaged cartilage surface.

20. The method of claim 13 , wherein the image data includes image data of subchondral bone underlying the diseased or damaged cartilage surface.

21. A method of manufacturing a surgical instrument for the repair of a diseased articular joint surface, comprising:

obtaining electronic image data of the diseased articular joint surface;

shaping an inner surface of the surgical instrument to match a curvature of the diseased articular joint surface derived from the electronic image data; and

including a slit in the surgical instrument to define a cutting path through at least a portion of the joint when the inner surface is applied to the diseased articular joint surface.

22. The method of claim 21 , wherein the step of shaping the inner surface of the surgical instrument further comprises matching a shape of the surgical instrument to a shape of the diseased articular joint surface.

23. The method of claim 21 , further comprising shaping the surgical instrument based at least in part on a size of the diseased articular joint surface.

24. The method of claim 21 , further comprising shaping the surgical instrument based at least in part on a size of diseased cartilage of the diseased articular joint surface.

25. The method of claim 21 , further comprising shaping the surgical instrument based at least in part on a curvature of diseased cartilage of the diseased articular joint surface.

26. The method of claim 21 , further comprising shaping the surgical instrument based at least in part on a shape of diseased cartilage of the diseased articular joint surface.

27. The method of claim 21 , further comprising shaping the surgical instrument based at least in part on a curvature of subchondral bone of the diseased articular joint surface.

28. The method of claim 21 , further comprising shaping the surgical instrument based at least in part on a shape of subchondral bone of the diseased articular joint surface.

29. The method of claim 21 , further comprising shaping the surgical instrument based at least in part on a curvature of subchondral bone underlying diseased cartilage of the diseased articular joint surface.

30. The method of claim 21 , wherein the image data includes image data of cartilage of the diseased articular joint surface.

31. The method of claim 21 , wherein the image data includes image data of subchondral bone of the diseased articular joint surface.

32. A method of manufacturing a surgical instrument for the repair of a diseased articular joint surface, comprising:

obtaining electronic image data of the diseased articular joint surface;

shaping an inner surface of the surgical instrument to match a curvature of cartilage of the diseased articular joint surface derived from the electronic image data; and

including a slit in the surgical instrument to define a cutting path through at least a portion of the joint when the inner surface is applied to the diseased articular joint surface.

33. The method of claim 32 , wherein the step of shaping the inner surface of the surgical instrument further comprises matching a shape of the surgical instrument to a shape of the diseased articular joint surface.

34. The method of claim 32 , further comprising shaping the surgical instrument based at least in part on a size of the diseased articular joint surface.

35. The method of claim 32 , further comprising shaping the surgical instrument based at least in part on a size of diseased cartilage of the diseased articular joint surface.

36. The method of claim 32 , further comprising shaping the surgical instrument based at least in part on a shape of diseased cartilage of the diseased articular joint surface.

37. The method of claim 32 , further comprising shaping the surgical instrument based at least in part on a curvature of subchondral bone of the diseased articular joint surface.

38. The method of claim 32 , further comprising shaping the surgical instrument based at least in part on a shape of subchondral bone of the diseased articular joint surface.

39. The method of claim 32 , further comprising shaping the surgical instrument based at least in part on a curvature of subchondral bone underlying diseased cartilage of the diseased articular joint surface.

40. The method of claim 32 , wherein the image data includes image data of cartilage of the diseased articular joint surface.

41. The method of claim 32 , wherein the image data includes image data of subchondral bone of the diseased articular joint surface.

Assignments (11)
RELEASE OF SECURITY INTEREST Recorded Sep 6, 2023
From: MIDCAP FINANCIAL TRUST, AS AGENT FOR LENDERS
To: CONFORMIS, INC.; IMATX, INC.
Reel/Frame 064818/0713 →
RELEASE OF SECURITY INTEREST Recorded Nov 23, 2021
From: CONFORMIS, INC.; IMATX, INC.; CONFORMIS CARES LLC
To: INNOVATUS LIFE SCIENCES LENDING FUND I, LP
Reel/Frame 058234/0292 →
SECURITY INTEREST Recorded Nov 22, 2021
From: CONFORMIS, INC.; IMATX, INC.
To: MIDCAP FINANCIAL TRUST, AS AGENT
Reel/Frame 058219/0346 →
RELEASE OF SECURITY INTEREST Recorded Sep 12, 2019
From: VENTURE LENDING & LEASING V, INC.; VENTURE LENDING & LEASING VI, INC.
To: CONFORMIS, INC.
Reel/Frame 050352/0372 →
RELEASE OF SECURITY INTEREST Recorded Jun 26, 2019
From: OXFORD FINANCE LLC, AS COLLATERAL AGENT
To: CONFORMIS, INC.
Reel/Frame 049599/0084 →
SECURITY INTEREST Recorded Jun 25, 2019
From: CONFORMIS, INC.; IMATX, INC.; CONFORMIS CARES LLC
To: INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT
Reel/Frame 049588/0288 →
SECURITY INTEREST Recorded Jul 31, 2018
From: CONFORMIS, INC.
To: OXFORD FINANCE LLC, AS COLLATERAL AGENT
Reel/Frame 046676/0152 →
CORRECTIVE ASSIGNMENT TO CORRECT THE INCORRECT SERIAL NUMBER 13/013466 PREVIOUSLY RECORDED AT REEL: 033460 FRAME: 0396. ASSIGNOR(S) HEREBY CONFIRMS THE RELEASE OF SECURITY INTEREST. Recorded Oct 20, 2016
From: VENTURE LENDING & LEASING V, INC.; VENTURE LENDING & LEASING VI, INC.
To: CONFORMIS, INC.
Reel/Frame 040424/0437 →
RELEASE OF SECURITY INTEREST Recorded Aug 1, 2014
From: VENTURE LENDING & LEASING V, INC. & VENTURE LENDING & LEASING VI, INC.
To: CONFORMIS, INC.
Reel/Frame 033460/0396 →
SECURITY AGREEMENT Recorded Feb 23, 2011
From: CONFORMIS, INC.
To: VENTURE LENDING & LEASING VI, INC.; VENTURE LENDING & LEASING V, INC.
Reel/Frame 025833/0753 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 16, 2010
From: LANG, PHILIPP; STEINES, DANIEL
To: CONFORMIS, INC.
Reel/Frame 024841/0761 →