IP Library Granted Patent US 8,097,170
Granted Patent B2
US 8,097,170 · App. 12/778,959 · Granted Jan 17, 2012

Process for treating a liquid medium

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Quick Facts
Patent No.
US 8,097,170
App. No.
12/778,959
Granted
Jan 17, 2012
Kind
B2
Abstract

A device for treating liquid medium has an ultrasound emitter located relative to a compartment of a container holding a liquid medium and a microbubble emitter located relative to the compartment. The ultrasound emitter emits high-frequency ultrasound between about 200 KHz and 10 MHz. The microbubble emitter emits bubbles with an average diameter of less than 1 mm.

Claims (13)

1. A method for treating human or animal cells displaying a hyperproliferative effect comprising:

providing a liquid medium containing said human or animal cells displaying a hyperproliferative effect;

injecting gas comprising microbubbles and high frequency ultrasound into the liquid medium, said high frequency ultrasound being between about 200 kHz and 10 MHz, wherein exposure to the gas and high frequency ultrasound inhibits a recovery threshold of the human or animal cells displaying a hyperproliferative effect.

2. The method according to claim 1 , wherein exposure to the gas and high frequency ultrasound enhances sonoluminesence.

3. The method according to claim 1 , wherein the cells displaying a hyperproliferative effect are at least one of tumor cells, bone marrow cells, and totipotent cells.

4. The method of claim 1 , wherein said providing comprises removing a physiological fluid from a human or animal.

5. The method of claim 1 , wherein said injecting gas and high frequency ultrasound is performed without the addition of photosensitizing molecules to said medium.

6. The method of claim 1 , wherein the gas comprises air.

7. The method of claim 1 , wherein exposure to gas and high-frequency ultrasound promotes the formation of radicals in the liquid medium.

8. The method of claim 1 , wherein exposure to gas and high-frequency ultrasound promotes the formation of molecules toxic to the cells displaying a hyperproliferative effect in the medium.

9. The method of claim 1 , comprising exposing said medium to electromagnetic radiation.

10. The method of claim 9 , wherein said electromagnetic radiation comprises one or more of microwave, infrared, visible, ultraviolet, and/or laser radiation.

11. The method of claim 1 , comprising reducing or maintaining microorganisms liable to multiply in the liquid medium below a selected concentration level.

Assignments (14)
RELEASE OF SECURITY INTEREST Recorded Nov 10, 2021
From: CITIBANK, N.A.
To: SOLENIS TECHNOLOGIES, L.P.
Reel/Frame 058848/0636 →
RELEASE OF SECURITY INTEREST Recorded Nov 10, 2021
From: CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH
To: SOLENIS TECHNOLOGIES, L.P.
Reel/Frame 058856/0724 →
INTELLECTUAL PROPERTY SECOND LIEN SECURITY AGREEMENT RELEASE Recorded Jul 20, 2018
From: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
To: SOLENIS TECHNOLOGIES, L.P.
Reel/Frame 047058/0800 →
INTELLECTUAL PROPERTY FIRST LIEN SECURITY AGREEMENT RELEASE Recorded Jul 20, 2018
From: CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH, AS COLLATERAL AGENT
To: SOLENIS TECHNOLOGIES, L.P.
Reel/Frame 046594/0252 →
FIRST LIEN NOTICE AND CONFIRMATION OF GRANT OF SECURITY INTEREST IN PATENTS Recorded Jul 20, 2018
From: SOLENIS TECHNOLOGIES, L.P.
To: CITIBANK, N.A., COLLATERAL AGENT
Reel/Frame 046595/0241 →
SECOND LIEN NOTICE AND CONFIRMATION OF GRANT OF SECURITY INTEREST IN PATENTS Recorded Jul 20, 2018
From: SOLENIS TECHNOLOGIES, L.P.
To: CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH, AS COLLATERAL AGENT
Reel/Frame 046629/0213 →
NOTICE AND CONFIRMATION OF GRANT OF SECURITY INTEREST IN PATENTS (FIRST LIEN) Recorded Aug 14, 2014
From: SOLENIS TECHNOLOGIES, L.P.
To: CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH, AS COLLATERAL AGENT
Reel/Frame 033535/0806 →
NOTICE AND CONFIRMATION OF GRANT OF SECURITY INTEREST IN PATENTS (SECOND LIEN) Recorded Aug 14, 2014
From: SOLENIS TECHNOLOGIES, L.P.
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 033535/0847 →
U.S. ASSIGNMENT OF PATENTS Recorded Aug 4, 2014
From: ASHLAND LICENSING AND INTELLECTUAL PROPERTY LLC
To: SOLENIS TECHNOLOGIES, L.P.
Reel/Frame 033471/0048 →
RELEASE OF PATENT SECURITY AGREEMENT Recorded Mar 18, 2013
From: THE BANK OF NOVA SCOTIA
To: ASHLAND LICENSING AND INTELLECTUAL PROPERTY LLC; AQUALON COMPANY; ISP INVESTMENTS INC.; HERCULES INCORPORATED
Reel/Frame 030025/0320 →
SECURITY AGREEMENT Recorded Sep 16, 2011
From: ASHLAND LICENSING AND INTELLECTUAL PROPERTY LLC; HERCULES INCORPORATED; AQUALON COMPANY; ISP INVESTMENT INC.
To: THE BANK OF NOVA SCOTIA, AS ADMINISTRATIVE AGENT
Reel/Frame 026918/0052 →
RELEASE OF PATENT SECURITY AGREEMENT Recorded Sep 15, 2011
From: BANK OF AMERICA, N.A.
To: ASHLAND, INC.; ASHLAND LICENSING AND INTELLECTUAL PROPERTY LLC; AQUALON COMPANY; HERCULES INCORPORATED
Reel/Frame 026927/0247 →
CORRECTIVE ASSIGNMENT TO CORRECT THE 12/282,556 PREVIOUSLY RECORDED ON REEL 024745 FRAME 0815. ASSIGNOR(S) HEREBY CONFIRMS THE SECURITY AGREEMENT. Recorded Aug 2, 2010
From: HERCULES INCORPORATED; ASHLAND LICENSING AND INTELLECTUAL PROPERTY LLC
To: BANK OF AMERICA, N.A.
Reel/Frame 024777/0799 →
SECURITY AGREEMENT Recorded Jul 27, 2010
From: ASHLAND LICENSING AND INTELLECTUAL PROPERTY LLC; HERCULES INCORPORATED
To: BANK OF AMERICA, N.A.
Reel/Frame 024745/0815 →