Modulators of 5-HT receptors and methods of use thereof

1. A compound of formula (I):

or a pharmaceutically acceptable salt thereof, wherein

A is

R 1 , R 3 , R 4 , and R 5 are independently selected from the group consisting of hydrogen, alkenyl, alkyl, haloalkyl, G 1 , G 2 , —(CR 4a R 5a ) m -G 1 , and —(CR 4a R 5a ) m -G 2 ;

R 4a and R 5a , at each occurrence, are each independently hydrogen, halogen, alkyl, or haloalkyl;

G 1 , at each occurrence, is independently aryl or heteroaryl, wherein each G 1 is independently unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of alkyl, alkenyl, alkynyl, halogen, cyano, —NO 2 , —OR 1b , —OC(O)R 1b , —OC(O)N(R b )(R 3b ), —SR 1b , —S(O)R 2b , —S(O) 2 R 2b , —S(O) 2 N(R b )(R 3b ), —C(O)R 1b , —C(O)OR 1b , —C(O)N(R b )(R 3b ), —N(R b )(R 3b ), —N(R a )C(O)R 1b , —N(R a )C(O)O(R 1A ), —N(R a )C(O)N(R b )(R 3b ), —(CR 4b R 5b ) m —NO 2 , —N(R b )S(O) 2 (R 2b ), —(CR 4b R 5b ) m —OR 1b , —C(OH)[(CR 4b R 5b ) m —R 4b ] 2 , —(CR 4b R 5b ) m —OC(O)R 1b , —(CR 4b R 5b ) m —OC(O)N(R b )(R 3b ), —(CR 4b R 5b ) m —SR 1b , —(CR 4b R 5b ) m —S(O)R 2b , —(CR 4b R 5b ) m —S(O) 2 R 2b , —(CR 4b R 5b ) m —S(O) 2 N(R b )(R 3b ), —(CR 4b R 5b ) m —C(O)R 1b , —(CR 4b R 5b ) m —C(O)OR 1b , —(CR 4b R 5b ) m —C(O)N(R b )(R 3b ), —(CR 4b R 5b ) m —N(R b )(R 3b ), —(CR 4b R 5b ) m —N(R a )C(O)R 1b , —(CR 4b R 5b ) m —N(R a )C(O)O(R 1b ), —(CR 4b R 5b ) m —N(R a )C(O)N(R b )(R 3b ), —(CR 4b R 5b ) m —N(R b )S(O) 2 (R 2b ), cyanoalkyl, and haloalkyl;

G 2 is cycloalkyl, cycloalkenyl, or heterocycle unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of alkyl, alkenyl, alkynyl, halogen, cyano, oxo, —SR 1b , —S(O)R 2b , —S(O) 2 R 2b , —S(O) 2 N(R b )(R 3b ), —C(O)R 1b , —C(O)OR 1b , —C(O)N(R b )(R 3b ), —N(R b )(R 3b ), —N(R a )C(O)R 1b , —N(R a )C(O)O(R 1b ), —N(R a )C(O)N(R b )(R 3b ), —(CR 4b R 5b ) m —NO 2 , —N(R b )S(O)(R 2b ), —(CR 4b R 5b ) m —OR 1b , —(CR 4b R 5b ) m —OC(O)R 1b , —(CR 4b R 5b ) m —OC(O)N(R b )(R 3b ), —(CR 4b R 5b ) m —SR 1b , —(CR 4b R 5b ) m —S(O)R 2b , —(CR 4b R 5b ) m —S(O) 2 R 2b , —(CR 4b R 5b ) m —S(O) 2 N(R b )(R 3b ), —(CR 4b R 5b ) m —C(O)R 1b , —(CR 4b R 5b ) m —C(O)OR 1b , —(CR 4b R 5b ) m —C(O)N(R b )(R 3b ), —(CR 4b R 5b ) m —N(R b )(R 3b ), —(CR 4b R 5b ) m —N(R a )C(O)R 1b , —(CR 4b R 5b ) m —N(R a )C(O)O(R 1b ), —(CR 4b R 5b ) m —N(R a )C(O)N(R b )(R 3b ), —(CR 4b R 5b ) m —N(R b )S(O) 2 (R 2b ), cyanoalkyl, and haloalkyl;

R a and R b , at each occurrence, are each independently hydrogen, alkyl, or haloalkyl;

R 1b and R 3b , at each occurrence, are each independently hydrogen, alkyl, or haloalkyl;

R 2b , at each occurrence, is independently alkyl or haloalkyl;

R 4b and R 5b , at each occurrence, are each independently hydrogen, halogen, alkyl, or haloalkyl;

m, at each occurrence, is independently 1, 2, 3, 4, or 5;

R 2 is selected from the group consisting of hydrogen, alkoxyalkyl, alkyl, alkylcarbonyl, haloalkyl, —(CR 4a R 5a ) m -G 1 , —(CR 4a R 5a ) p —O-G 1 , —C(O)-G 1 , —(CR 4a R 5a ) m -G 2 , —(CR 4a R 5a ) p —O- G 2 , —C(O)-G 2 , —S(O) 2 R 6 , and —C(O)NR 7 R 8 ;

p, at each occurrence, is independently 2, 3, 4, or 5;

R 6 and R 7 are independently selected from the group consisting of alkyl, haloalkyl, G 1 , —(CR 4a R 5a ) m -G 1 , G 2 and —(CR 4a R 5a ) m -G 2 ;

R 8 is selected from the group consisting of hydrogen, alkyl, and haloalkyl; or

R 7 and R 8 taken together with the nitrogen to which they are attached form a heterocycle;

X 1 is CR 9 ;

X 2 is CR 10 ;

X 3 is CR 11 ;

X 4 is CR 12 ;

R 9 , R 10 , R 11 and R 12 are each independently hydrogen, alkyl, alkenyl, alkynyl, halogen, cyano, -G 1 , -G 2 , —NO 2 , —OR 1a , —OC(O)R 1a , —OC(O)N(R b )(R 3a ), —SR 1a , —S(O)R 2a , —S(O) 2 R 2a , —S(O) 2 N(R b )(R 3a ), —C(O)R 1a , —C(O)G 3 , —C(O)OR 1a , —C(O)N(R b )(R 3a ), —N(R b )(R 3a ), —N(R a )C(O)R 1a , —N(R a )C(O)O(R 1a ), —N(R a )C(O)N(R b )(R 3a ), —N(R a )S(O) 2 (R 2a ), —(CR 4a R 5a ) m —NO 2 , —(CR 4a R 5a ) m —OR 1a , —(CR 4a R 5a ) m —OC(O)R 1a , —(CR 4a R 5a ) m —OC(O)N(R b )(R 3a ), —(CR 4a R 5a ) m —SR 1a , —(CR 4a R 5a ) m —S(O)R 2a , —(CR 4a R 5a ) m —S(O) 2 R 2a , —(CR 4a R 5a ) m —S(O) 2 N(R b )(R 3a ), —(CR 4a R 5a ) m —C(O)R 1a , —(CR 4a R 5a ) m —C(O)OR 1a , —(CR 4a R 5a ) m —C(O)N(R b )(R 3a ), —(CR 4a R 5a ) m —N(R b )(R 3a ), —(CR 4a R 5a ) m —N(R a ) C(O)R 1a , —(CR 4a R 5a ) m —N(R a )C(O)O(R 1a ), —(CR 4a R 5a ) m —N(R a ) C(O)N(R b )(R 3a ), —(CR 4a R 5a ) m -G 1 , —CR 4a ═CR 5a -G 1 , —(CR 4a R 5a ) m -G 2 , —CR 4a ═CR 5a -G 2 , —CR 6a ═C(R 7a ) 2 , cyanoalkyl, haloalkyl, (v), (vi), (vii) or (vi); wherein

R 1a and R 3a , at each occurrence, are each independently hydrogen, alkyl, haloalkyl, G 1 , —(CR 4a R 5a ) m -G, G 2 , or —(CR 4a R 5a ) m -G 2 ;

R 2 , at each occurrence, is independently alkyl, haloalkyl, G 1 , or —(CR 4a R 5a ) m -G 1 ;

R 6a is alkyl or haloalkyl;

R 7 , at each occurrence, is independently hydrogen, alkyl, or haloalkyl;

G 3 is a heterocyclic ring attached to the adjacent carbonyl moiety through a nitrogen atom contained within the heterocycle;

q is 1 or 2;

Y 1 is C(O);

Y 2 is NR 20 ;

Y 3 is CR 18 R 19 ;

R 18 and R 19 are independently selected from the group consisting of hydrogen, alkyl, and haloalkyl;

n is 1 or 2; and

R 20 is selected from the group consisting of hydrogen, alkyl, alkylcarbonyl, haloalkyl, —C(O)-G 1 , —C(O)NR a -G 1 , —S(O) n -G 1 , —(CR 4a R 5a ) m -G 1 , —C(O)-G 2 , —C(O)NR a -G 2 , —S(O) n -G 2 , and —(CR 4a R 5a ) m -G 2 .

2. The compound of claim 1 , wherein R 2 is selected from the group consisting of hydrogen, alkyl, haloalkyl, —(CR 4a R 5a ) m -G 1 , and —S(O) 2 R 6 .

3. The compound of claim 1 , wherein R 9 , R 10 , R 11 , and R 12 are each hydrogen, or wherein one or two of R 9 , R 10 , R 11 , and R 12 are each independently alkyl, alkenyl, alkynyl, halogen, cyano, -G 1 , -G 2 , —OR 1a , —NO 2 , —OC(O)R 1a , —OC(O)N(R b )(R 3a ), —SR 1a , —S(O)R 2a , —S(O) 2 R 2a , —S(O) 2 N(R b )(R 3a ), —C(O)R 1a , —C(O)G 3 , —C(O)OR 1a , —C(O)N(R b )(R 3a ), —N(R b )(R 3a ), —N(R a )C(O)R 1a , —N(R a )C(O)O(R a ), —N(R a )C(O)N(R b ) R 3a ), —N(R a )S(O) 2 (R 2a ), —(CR 4a R 5a ) m —NO 2 , —(CR 4a R 5a ) m —OR 1a , —(CR 4a R 5a ) m —OC(O)R 1a , —(CR 4a R 5a ) m —OC(O)N(R b )(R 3a ), —(CR 4a R 5a ) m —SR 1a , —(CR 4a R 5a ) m —S(O)R 2a , —(CR 4a R 5a ) m —S(O) 2 R 2a , —(CR 4a R 5a ) m —S(O) 2 N(R b )(R 3a ), —(CR 4a R 5a ) m —C(O)R, —(CR 4a R 5a ) m —C(O)OR 1a , —(CR 4a R 5a ) m —C(O)N(R b )(R 3a ), —(CR 4a R 5a ) m —N(R b )(R 3a ), —(CR 4a R 5a ) m —N(R a )C(O)R, —(CR 4a R 5a ) m —N(R a )C(O)O(R a ), —(CR 4a R 5a )N(R a )C(O)N(R b )(R 3a ), —(CR 4a R 5a ) m -G 1 , —CR 4a ═CR 5a -G 1 , —(CR 4a R 5a ) m -G 2 , CR 4a ═CR 5a -G 2 , cyanoalkyl, haloalkyl, (v), (vi), (vii) or (viii), and the others of R 9 , R 10 , R 11 , and R 12 are hydrogen

4. The compound of claim 1 , wherein the compound is selected from the group consisting of:

trans-2-benzyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

cis-2-benzyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

cis-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-2-(3,5-dimethylbenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-2-(2,5-dimethylbenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-2-(2,4-dimethylbenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-2-(3,4-dimethylbenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-2-(3-methylbenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-2-(2,3-dimethylbenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-2-(3-methoxybenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-2-(2-methoxybenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-2-(3,5-dichlorobenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-2-(2,5-dichlorobenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-2-(3-chlorobenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-2-(2-chlorobenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-2-(3-fluorobenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-2-(2-fluorobenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

3-((trans-6-oxo-1,3a,4,5,6,10b-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-2(3H)-yl)methyl)benzonitrile;

trans-2-(2,5-dimethoxybenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-2-(3,5-dimethoxybenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

cis-2-(3,5-dichlorobenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

cis-2-(3-chlorobenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

cis-2-(3-fluorobenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

cis-2-(naphthalen-1-ylmethyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrlo[3,4-e]azepin-6(10bH)-one;

(3aR,10bS)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-2-benzyl-8-chloro-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-8-chloro-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

(3aR,10bS)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-2-benzyl-10-chloro-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(1bH)-one;

trans-7-chloro-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-2-benzyl-9-chloro-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-9-chloro-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-chloro-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-2-benzyl-8-fluoro-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-2-benzyl-8,9-dichloro-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-8-fluoro-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-2-benzyl-7-fluoro-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

cis-2-benzyl-7-fluoro-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-7-fluoro-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

(3aS,10bS)-2-benzyl-8-fluoro-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-7-fluoro-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-2-benzyl-9-fluoro-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-9-fluoro-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-2-benzyl-10-fluoro-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

cis-2-benzyl-10-fluoro-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-10-fluoro-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-methyl-3-((6-oxo-1,3a,4,5,6,10b-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-2(3H)-yl)methyl)benzoate;

trans-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-2-(5-chloro-2-fluorobenzyl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-(4-fluorophenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-(3-fluorophenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-(2-fluorophenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-(3,4-difluorophenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-2-methyl-8-(4-(trifluoromethyl)phenyl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-2-methyl-8-(naphthalen-2-yl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-2-methyl-8-m-tolyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-2-methyl-8-p-tolyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-2-methyl-8-(4-(methylsulfonyl)phenyl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-2-methyl-8-(3-(methylsulfonyl)phenyl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-2-methyl-8-styryl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-2-methyl-8-phenyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-2-methyl-8-phenethyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-methyl 2-methyl-6-oxo-1,2,3,3a,4,5,6,10b-octahydrobenzo[e]pyrrolo[3,4-c]azepine-8-carboxylate;

trans-10-fluoro-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-9-fluoro-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-fluoro-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-7-fluoro-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-2-benzyl-8,10-dimethoxy-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-8,10-dimethoxy-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-2-benzyl-7-(trifluoromethoxy)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-7-(trifluoromethoxy)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

(3aS,10bS)-2-benzyl-8,10-difluoro-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

(3aR,10bS)-8,10-difluoro-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-2-methyl-7-(trifluoromethoxy)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

(3aR,10bR)-2-methyl-7-(trifluoromethoxy)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

(3aS,10bS)-2-methyl-7-(trifluoromethoxy)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-2-methyl-7-phenyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

(3aS,10bS)-8-(4-fluorophenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

(3aR,10bR)-8-(4-fluorophenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-2-benzyl-8-hydroxy-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-2-benzyl-8-((R)-1-phenylpropan-2-yloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-2-benzyl-8-(3-fluorophenethoxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-2-benzyl-8-((S)-1-phenylpropan-2-yloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-2-benzyl-8-phenethoxy-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-2-methyl-8-(piperidine-1-carbonyl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-phenethoxy-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-(3-fluorophenethoxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-N,2-dimethyl-6-oxo-1,2,3,3a,4,5,6,10b-octahydrobenzo[e]pyrrolo[3,4-c]azepine-8-carboxamide;

trans-2-methyl-6-oxo-N-phenethyl-1,2,3,3a,4,5,6,10b-octahydrobenzo[e]pyrrolo[3,4-c]azepine-8-carboxamide;

trans-2-methyl-6-oxo-N-(3-(trifluoromethyl)phenethyl)-1,2,3,3a,4,5,6,10b-octahydrobenzo[e]pyrrolo[3,4-c]azepine-8-carboxamide;

trans-2-methyl-6-oxo-N-phenyl-1,2,3,3a,4,5,6,10b-octahydrobenzo[e]pyrrolo[3,4-c]azepine-8-carboxamide;

trans-methyl 2-benzyl-6-oxo-1,2,3,3a,4,5,6,10b-octahydrobenzo[e]pyrrolo[3,4-c]azepine-8-carboxylate;

cis-2-benzyl-8-methoxy-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-(4-methoxyphenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-2-methyl-8-(3-(trifluoromethoxy)phenyl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-(3-methoxyphenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-(3-isobutoxyphenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

cis-8-methoxy-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-2-benzyl-8-(1,3,4-oxadiazol-2-yl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-(2-methoxyphenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-(4-isopropylphenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-(4-ethylphenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-2-methyl-8-(4-(trifluoromethoxy)phenyl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6 (10bH)-one;

trans-8-amino-2-benzyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

cis-8-amino-2-benzyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-2-methyl-8-(pyridin-3-yl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-amino-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

cis-8-amino-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-(3-fluorobenzyloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-(2-fluorobenzyloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-(2-(trifluoromethyl)benzyloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-((S)-1-phenylpropan-2-yloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-((R)-1-phenylethoxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-((S)-1-phenylethoxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-((R)-1-phenylpropan-2-yloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

(3aS,10bS)-8-(4-methoxyphenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

(3aR,10bR)-8-(4-methoxyphenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

(3aS,10 bS)-8-(3-methoxyphenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

(3aR,10bR)-8-(3-methoxyphenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

(3aS,10bS)-8,10-difluoro-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

(3aR,10bS)-8-fluoro-2,5-dimethyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-(2-fluorobenzyloxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-sec-butoxy-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-isobutoxy-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-(cyclohexylmethoxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-(2,6-difluorobenzyloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-(isopentyloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-sec-butoxy-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-(isopentyloxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-isobutoxy-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-(2-methoxyphenethoxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-(3-methoxyphenethoxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-(4-methoxyphenethoxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-(cyclohexylmethoxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-(pyridin-4-yl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-(2-methoxypyrimidin-5-yl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

(3aR,10bS)-8-(2-fluorobenzyloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

(3aS,10bR)-8-(2-fluorobenzyloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

(3aR,10bS)-8-((R)-1-phenylpropan-2-yloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

(3aS,10bR)-8-((R)-1-phenylpropan-2-yloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-(2-methoxyphenethoxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-(thiophen-3-yl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6 (10bH)-one;

trans-2-methyl-8-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6 (10bH)-one;

trans-8-(3-(2-hydroxypropan-2-yl)phenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6 (10bH)-one;

trans-8-(3-acetylphenyl)-5-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-methoxy-5-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-(3-(2-hydroxyethyl)phenyl)-5-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-methoxy-2,5-dimethyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-(3-acetylphenyl)-2,5-dimethyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-(3-(2-hydroxyethyl)phenyl)-2,5-dimethyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6 (10bH)-one;

trans-8-(3-(1-hydroxyethyl)phenyl)-2,5-dimethyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6 (10bH)-one;

trans-8-(3-(2-hydroxypropan-2-yl)phenyl)-2,5-dimethyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6 (10bH)-one;

trans-8-(benzo[e][1,2,5]oxadiazol-5-yl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6 (10bH)-one;

trans-8-isopropyl-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-2-methyl-8-(2-methylprop-1-enyl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-3-(2-methyl-6-oxo-1,2,3,3a,4,5,6,10b-octahydrobenzo[e]pyrrolo[3,4-c]azepin-8-yl)benzaldehyde;

(3aS,10bS)-8-chloro-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

(3aS,10bS)-8-hydroxy-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-cyclopentenyl-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-2-methyl-8-(3,3,3-trifluoroprop-1-en-2-yl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-2-methyl-8-(5-methylfuran-2-yl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-cyclohexyl-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-cyclopentyl-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

(3aS,10bS)-8-(3-fluorobenzyloxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

(3aS,10bS)-8-(2-fluorobenzyloxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

(3aS,10bS)-8-(3,5-difluorobenzyloxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

3aS,10bS)-8-(2,6-difluorobenzyloxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

(3aS,10bS)-8-(3,4-difluorobenzyloxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

(3aS,10bS)-8-(4-fluorobenzyloxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

(3aS,10bS)-8-(2,3-difluorobenzyloxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

(3aS,10bS)-2-methyl-8-(2,3,6-trifluorobenzyloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-(benzyloxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-8-(3-fluorobenzyloxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-2-benzyl-8-(4-fluorophenyl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-(4-fluorophenyl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

(3aR,10bS)-8-(4-fluorophenyl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

(3aS,10bR)-8-(4-fluorophenyl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-fluoro-5-methyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

(3aR,10bS)-8-fluoro-5-methyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

(3aS,10bR)-8-fluoro-5-methyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-8-(3-(methylsulfonyl)phenyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

(3aS,10bS)-2-methyl-8-(3-(methylsulfonyl)phenyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6 (10bH)-one;

(3aR,10bR)-2-methyl-8-(3-(methylsulfonyl)phenyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6 (10bH)-one;

N,N-dimethyl-3-(trans-6-oxo-1,2,3,3a,4,5,6,10b-octahydrobenzo[c]pyrrolo[3,4-e]azepin-8-yl)benzamide;

trans-8-(2-(methylsulfonyl)phenyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-2-methyl-8-(2-(methylsulfonyl)phenyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-8-(3-acetylphenyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one hydrochloride;

trans-8-(3-acetylphenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-8-(3-(1-hydroxyethyl)phenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

3-(trans-6-oxo-1,2,3,3a,4,5,6,10b-octahydrobenzo[c]pyrrolo[3,4-e]azepin-8-yl)benzonitrile;

3-(trans-2-methyl-6-oxo-1,2,3,3a,4,5,6,10b-octahydrobenzo[c]pyrrolo[3,4-e]azepin-8-yl)benzonitrile;

trans-8-(3,6-dihydro-2H-pyran-4-yl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-8-(3,6-dihydro-2H-pyran-4-yl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-8-(4-fluorophenoxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-8-isobutyl-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-(3,5-dimethylisoxazol-4-yl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-(4,4-dimethylcyclohexyloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-(3-oxo-2,3-dihydro-1H-inden-5-yl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

(3aS,10bS)-8-(3-((S)-1-hydroxyethyl)phenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

(3aS,10bS)-8-(3-((R)-1-hydroxyethyl)phenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

trans-8-(3-(ethylsulfonyl)phenyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-2-methyl-8-(3-oxo-2,3-dihydro-1H-inden-5-yl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-8-(3-(2-hydroxyethyl)phenyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-8-(3-(2-hydroxyethyl)phenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-8-(3-(ethylsulfonyl)phenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-8-(tetrahydro-2H-pyran-4-yl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

trans-2-methyl-8-(tetrahydro-2H-pyran-4-yl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

(3aS,10bS)-8-(benzyloxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

(3aS,10bS)-8-(2-methoxyphenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6 (10bH)-one;

trans-8-(2,6-difluorophenyl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

(3aS,10bS)-8-(cyclopropylmethoxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6 (10bH)-one;

(3aS,10bS)-8-(3-acetylphenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one; and

cis-8-fluoro-9-methyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;

or a pharmaceutically acceptable salt thereof.

5. The compound according to claim 1 of formula (Ia):

or a pharmaceutically acceptable salt thereof, wherein

R 20 is hydrogen or alkyl.

6. The compound according to claim 5 , wherein

R 1 and R 3 are hydrogen; and

R 2 is hydrogen, alkyl, haloalkyl, —(CR 4a R 5a ) m -G 1 or —(CR 4a R 5a ) m -G 2 .

7. A method for treating conditions, disorders or deficits modulated by a 5-HT 2C receptor, a 5-HT 6 receptor or both 5-HT 2C and 5-HT 6 receptors wherein the condition, disorder or deficit is selected from the group consisting of a cognitive dysfunction, attention deficit/hyperactivity syndrome, personality disorders, affective disorders, motion or motor disorders, migraine, sleep disorders, feeding disorders, gastrointestinal disorders, diseases associated with neurodegeneration, obesity, diabetes, psoriasis, and ocular hypertension, the method comprising administration of a therapeutically effective amount of the compound of claim 4 , or a pharmaceutically acceptable salt thereof.

8. A method for treating a disorder or condition modulated by the 5-HT 2 , receptor selected from the group consisting of bipolar disorder, depression, anxiety, schizophrenia, cognitive deficits of schizophrenia, obsessive compulsive disorder, migraine, epilepsy, eating disorders, obesity, diabetes, sexual dysfunction/erectile dysfunction, sleep disorders, psoriasis, Parkinson's disease, pain and spinal cord injury, pain, bladder dysfunction/urinary incontinence, smoking cessation, ocular hypertension, and Alzheimer's disease, said method comprising the step of administering to a subject in need thereof the compound of claim 4 , or a pharmaceutically acceptable salt thereof.

9. The method according to claim 8 wherein the disorder modulated by the 5-HT 2 receptor is schizophrenia or cognitive deficits of schizophrenia.

10. A method for treating a disorder modulated by the 5-HT 6 receptor selected from the group consisting of deficits in memory and cognition and learning, Alzheimer's disease, age-related cognitive decline, mild cognitive impairment, attention deficit/hyperactivity syndrome, schizophrenia, cognitive deficits of schizophrenia, depression, anxiety, obsessive compulsive disorders, Parkinson's disease, epilepsy, migraine, sleep disorders, anorexia, bulimia, irritable bowel syndrome, stroke, spinal or head trauma and head injuries, and obesity, said method comprising the step of administering to a subject in need thereof the compound of claim 4 , or a pharmaceutically acceptable salt thereof.

11. A pharmaceutical composition comprising a therapeutically effective amount of the compound of claim 4 , or a pharmaceutically acceptable salt thereof, in combination with one or more pharmaceutically acceptable carriers.

12. A process for making (3aS,10bS)-8-chloro-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one dibenzyoyl-D-tartrate comprising:

(a) combining dibenzoyl-D-tartaric acid (1.05 equivalents) and methanol;

(b) adding a solution of trans-8-chloro-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one (0.10-0.15 equivalents) in methanol;

(c) seeding the solution with (3aS,10bS)-8-chloro-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one which are obtained in smaller batches of the same sequence iteratively increasing the enantiomeric excess in successive passage;

(d) slowly adding additional trans-8-chloro-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one (0.85-0.90 equivalents) dissolved in methanol; and

(e) stirring the resultant mixture for a period of time resulting in crystallization and isolating the crystalline (3aS,10bS)-8-chloro-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one dibenzyoyl-D-tartrate.

13. A process for making (3aS,10bS)-8-hydroxy-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one comprising:

(a) combining palladium(II) acetate (0.04 equivalents), 2-di-tert-butylphosphino-3,4,5,6-tetramethyl-2′,4′,6′-triisopropyl-1,1′-biphenyl (0.05 equivalents), cesium carbonate (1.5 equivalents) and (3aS,10bS)-8-chloro-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one (1 equivalent);

(b) adding a solution of benzyl alcohol (20 equivalents) in toluene to the mixture of palladium(II) acetate, 2-di-tert-butylphosphino-3,4,5,6-tetramethyl-2′,4′,6′-triisopropyl-1,1′-biphenyl, cesium carbonate and (3aS,10bS)-8-chloro-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

(c) isolating the (3aS,10bS)-8-(benzyloxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;

(d) hydrogenating (3aS,10bS)-8-(benzyloxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one to generate (3aS,10bS)-8-hydroxy-2-methyl-1,2,3,3a,4,5-hexahydrobenzo [e]pyrrolo[3,4-c]azepin-6(10bH)-one; and

(e) isolating the (3aS,10bS)-8-hydroxy-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one.