Granted Patent
B2
US 8,227,623 · App. 12/785,805 · Granted Jul 24, 2012
Process for the preparation of asenapine and intermediate products used in said process
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Abstract
The invention relates to a novel process for the preparation of asenapine, i.e. trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole, as well as to novel intermediate products for use in said process.
Claims (5)
1. The trans-pyrrolidine derivative of Formula IIIA,
or a salt thereof,
wherein R 1 is F, Br or I; and
R 2 and R 3 are different and are each selected from H and Cl.
2. The trans-pyrrolidine derivative of claim 1 , which is trans-N-methyl-2-bromophenyl-3-(2-hydroxy-5-chlorophenyl)-pyrrolidine.
Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 29, 2014
From: MERCK SHARP & DOHME BV; ORGANON LIMITED
To: FOREST LABORATORIES HOLDINGS LIMITED
Reel/Frame 032077/0550 →
MERGER
Recorded Mar 8, 2013
From: ORGANON BIOSCIENCES NEDERLAND B.V.
To: MERCK SHARP & DOHME B.V.
Reel/Frame 029940/0296 →
MERGER
Recorded Mar 7, 2013
From: MSD OSS B.V.
To: ORGANON BIOSCIENCES NEDERLAND B.V.
Reel/Frame 029939/0001 →