IP Library › Granted Patent US 8,263,568
Granted Patent B2
US 8,263,568 · App. 12/787,260 · Granted Sep 11, 2012

Chromatography of metal complexes

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Quick Facts
Patent No.
US 8,263,568
App. No.
12/787,260
Granted
Sep 11, 2012
Kind
B2
Abstract

A high performance liquid chromatography method to routinely and reproducibly detect and quantitate metal complexes is provided. The metal complexes used in the method of the invention can be different metal complexes, or they can be stereoisomers of the same metal complexes. The high performance liquid chromatography method of the present invention is suitable for the separation of diastereomers of the same metal complexes. Also provided is a chiral high performance liquid chromatography method to separate enantiomers of metal complexes. Superoxide dismutase mimetic compounds are also provided.

Claims (13)

1. A complex having the structure:

wherein X is a coordinating anion selected from the group consisting of chloride anions, thiocyanate anions, stearate anions, acetate anions, trifluoroacetate anions, carboxylate anions, formate anions and azide anions.

2. The complex of claim 1 wherein X is a chloride anion, a thiocyanate anion, or a formate anion.

3. The complex of claim 1 wherein X is a chloride anion or a thiocyanate anion.

4. A complex having the structure:

5. A complex having the structure:

6. A composition containing a single species of a Mn II (1,4,7,10,13-pentaazacyclopentadecane) complex corresponding to the formula:

wherein X is a coordinating anion selected from the group consisting of chloride anions, thiocyanate anions, stearate anions, acetate anions, trifluoroacetate anions, carboxylate anions, formate anions and azide anions.

7. The composition of claim 6 , wherein the composition is an HPLC chromatographic eluent comprising the single species of the Mn II (1,4,7,10,13-pentaazacyclopentadecane) complex.

8. The composition of claim 6 wherein X is a chloride anion, a thiocyanate anion, or a formate anion.

9. The composition of claim 6 wherein X is a chloride anion or a thiocyanate anion.

10. The composition of claim 6 wherein the Mn II (1,4,7,10,13-pentaazacyclopentadecane) complex has the formula:

11. The composition of claim 6 wherein the Mn II (1,4,7,10,13-pentaazacyclopentadecane) complex has the formula:

Assignments (9)
LICENSE Recorded Aug 29, 2018
From: INOTEK PHARMACEUTICALS CORPORATION
To: GALERA THERAPEUTICS, LLC
Reel/Frame 046974/0618 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 29, 2018
From: INOTEK PHARMACEUTICALS CORPORATION
To: GALERA THERAPEUTICS, LLC
Reel/Frame 046742/0286 →
BILL OF SALE Recorded Aug 29, 2018
From: ACTIVBIOTICS, INC.; METAPHORE PHARMACEUTICALS, INC.
To: INOTEK PHARMACEUTICALS CORPORATION; KEREOS, INC.
Reel/Frame 047092/0357 →
CHANGE OF NAME Recorded Aug 26, 2015
From: GALERA THERAPEUTICS, LLC
To: GALERA LABS, LLC
Reel/Frame 036427/0622 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 27, 2015
From: ACTIVBIOTICS, INC.; METAPHORE PHARAMCEUTICALS, INC.
To: KEREOS, INC.; INOTEK PHARMACEUTICALS CORPORATION
Reel/Frame 035276/0439 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 27, 2015
From: SLOMCZYNSKA, URSZULA J.; TRAWICK, BOBBY N.; RILEY, DENNIS P.; NAIK, ARATI
To: METAPHORE PHARMACEUTICALS, INC.
Reel/Frame 035276/0246 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 27, 2015
From: INOTEK PHARMACEUTICAL CORPORATION
To: GALERA THERAPEUTICS, LLC
Reel/Frame 035276/0554 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 27, 2015
From: KEREOS, INC.
To: GALERA THERAPEUTICS, LLC
Reel/Frame 035276/0653 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 8, 2012
From: BUCKLER, PHILLIP M.; BEARDSLEY, ROBERT A.
To: GALERA THERAPEUTICS
Reel/Frame 028750/0829 →