Optimized stent jacket
View Patent ↗A method of stenting, comprises: implanting a stent assembly in a vessel of a subject, the stent assembly, including: a stent jacket, comprising an expansible mesh structure, formed of fibers of a diameter between about 7 micrometers and about 18 micrometers, the diameter having a property of forming a substantially stable layer of endothelial cells, covering the fibers, thus reducing platelet aggregation, and an expansible stent, operatively associated with the stent jacket. The method further comprises administering to the subject an active pharmaceutical ingredient (API) comprising a platelet aggregation reducer for a shortened time period, not exceeding six months, the shortened time period being a consequence of the property. In accordance with some embodiments, the administration of a platelet aggregation.
1. A method of stenting, comprising:
implanting a stent assembly in a vessel of a subject, the stent assembly, including:
i. a knitted stent jacket, comprising an expansible mesh structure formed from fibers having a diameter between about 7 micrometers and about 40 micrometers; and
ii. an expansible stent, operatively associated with the stent jacket,
wherein the expansible mesh structure comprises a retracted state and a deployed state, wherein the expansible mesh structure defines apertures having a minimum center dimension greater than 160 micrometers in the deployed state, and wherein the expansible mesh structure has a thickness of greater than 12.5 micrometers to less than 100 micrometers.
2. The method of claim 1 , wherein the expansible mesh structure extends past at least one end of the expansible stent.
3. The method of claim 2 , wherein the expansible mesh structure extends past an end of the expansible stent to a distance of no more than 1 millimeter.
4. The method of claim 2 , wherein the expansible mesh structure extends more than 1 millimeter past an end of the expansible stent.
5. The method of claim 2 , wherein the expansible mesh structure extends past both ends of the expansible stent.
6. The method of claim 1 , wherein the fibers comprise polyethylene terephthalate (PET).
7. The method of claim 1 , wherein the expansible mesh structure has a thickness of greater than 12.5 micrometers and less than 30 micrometers.
8. A method of stenting, comprising:
implanting a stent assembly in a vessel of a subject, the stent assembly, including:
i. a stent jacket, comprising an expansible mesh structure, knitted from fibers having a diameter between about 7 micrometers and about 40 micrometers; and
ii. an expansible stent, operatively associated with the stent jacket, wherein the expansible mesh structure comprises a retracted state and a deployed state, wherein the expansible mesh structure defines apertures having a minimum center dimension greater than 100 micrometers and below 300 micrometers before implantation and when the expansible mesh structure is in the deployed state, wherein the expansible mesh structure has a thickness of greater than 12.5 micrometers to less than 100 micrometers.
9. The method of claim 8 , wherein the diameter is between about 10 and 20 micrometers.
10. The method of claim 8 , wherein the diameter is between about 15 and 20 micrometers.
11. The method of claim 8 , wherein the fibers of the expansible mesh structure directly contact a second fiber of the expansible mesh structure at each of a plurality of fiber junctions.
12. The method of claim 8 , wherein the expansible mesh structure defines apertures having a minimum center dimension, which is greater than about 160 micrometers.
13. The method of claim 12 , wherein the expansible mesh structure defines apertures having a minimum center dimension, which is greater than about 180 micrometers.
14. The method of claim 13 , wherein an amount of porous structure surface area of the stent jacket dedicated to structure is less than about 12%.
15. The method of claim 8 , wherein an amount of porous structure surface area of the stent jacket dedicated to structure is less than about 12%.
16. The method of claim 8 , wherein the stent jacket is knitted into a mesh structure by a head having 20-80 needles.
17. The method of claim 8 , wherein the fibers are formed of a biostable polymer or a natural polymer.
18. The method of claim 8 , wherein the fibers are formed of a biodegradable polymer.
19. The method of claim 18 , wherein the fibers of the expansible mesh structure directly contacts a second fiber of the expansible mesh structure at each of a plurality of fiber junctions.
20. The method of claim 8 , wherein the stent is adapted to treat an aneurism.
21. The method of claim 8 , wherein the stent is adapted to support blood vessels.
22. The method of claim 8 , wherein the stent is adapted to dilate body lumens.
23. The method of claim 8 , wherein the stent defines apertures having a diameter of several millimeters.
24. The method of claim 8 , wherein the jacket is formed of fibers that are each spaced a distance from a closest neighboring fiber, and wherein the fibers of the jacket that are spaced a distance from a closest neighboring fiber have a diameter of between about 7 micrometers and about 40 micrometers.
25. The method of claim 8 , wherein the fibers having a diameter of between about 7 micrometers and about 40 micrometers comprise super fibers made of multiple fibers braided together.
26. The method of claim 8 , wherein the expansible mesh structure has a thickness of greater than 12.5 micrometers and less than 30 micrometers.
27. The method of claim 8 , wherein the expansible mesh structure extends past at least one end of the expansible stent.
28. The method of claim 27 , wherein the expansible mesh structure extends past both ends of the expansible stent.
29. A stent assembly, comprising:
a. a knitted stent jacket, comprising an expansible mesh structure, formed of fibers having a diameter between about 7 micrometers and about 40 micrometers; and
b. an expansible stent, operatively associated with the stent jacket,
wherein the expansible mesh structure comprises a retracted state and a deployed state, the expansible mesh structure defines apertures having a minimum center dimension greater than 100 micrometers and below 300 micrometers before implantation and when the expansible mesh structure is in the deployed state, and
wherein the expansible mesh structure has a thickness of greater than 12.5 micrometers to less than 100 micrometers.
30. The stent assembly according to claim 29 , wherein the diameter is between about 11 micrometers and about 14 micrometers.
31. The stent assembly according to claim 29 , wherein the diameter is between about 12 micrometers and about 13 micrometers.
32. The stent assembly according to claim 29 , wherein the diameter is about 12.5 micrometers.
33. The stent assembly according to claim 29 , wherein the mesh is formed as a single knit.
34. The stent assembly according to claim 29 , wherein in the deployed state, the expansible mesh structure defines apertures, having a minimum center dimension, which is greater than about 160 micrometers, thus minimizing occurrences of a single endothelial cell adhering to more than one fiber, across one of the apertures, and reducing a chance of endothelial cells breaking free as a result of natural stent pulsation with blood flow.
35. The stent assembly according to claim 29 , wherein the minimum center dimension is greater than about 180 micrometers.
36. The stent assembly according to claim 29 , wherein the minimum center dimension is greater than about 200 micrometers.
37. The stent assembly according to claim 29 , wherein the minimum center dimension is greater than about 220 micrometers.
38. The stent assembly according to claim 29 , wherein the stent jacket comprises a small coverage area of between about 9% and about 12% of the surface area of the stent.
39. The stent assembly according to claim 29 , wherein the fibers are formed of a material, which encourages stable adherence of endothelial cells to the fibers.
40. The stent assembly according to claim 39 , wherein the material is selected from the group consisting of: stainless steel, nitinol, titanium, gold, a biostable polymer, and a natural polymer.
41. The stent assembly according to claim 29 , wherein the fiber of the expansible mesh structure directly contacts a second fiber of the expansible mesh structure at each of a plurality of fiber junctions.
42. The stent assembly according to claim 29 , wherein the fibers are formed of a biostable polymer or a natural polymer.
43. The stent assembly according to claim 29 , wherein the fibers are formed of a biodegradable polymer.
44. The stent assembly according to claim 29 , wherein the jacket is formed of fibers that are each spaced a distance from a closest neighboring fiber, and wherein the fibers of the jacket that are spaced a distance from a closest neighboring fiber have a diameter of between about 7 micrometers and about 40 micrometers.
45. The stent assembly according to claim 29 , wherein the fibers having a diameter of between about 7 micrometers and about 40 micrometers comprise super fibers made of multiple fibers braided together.
46. The stent assembly according to claim 29 , wherein the expansible mesh structure extends past at least one end of the expansible stent.
47. The stent assembly of claim 46 , wherein the expansible mesh structure extends past both ends of the expansible stent.