IP Library Granted Patent US 8,786,624
Granted Patent B2
US 8,786,624 · App. 12/792,582 · Granted Jul 22, 2014

Processing for multi-channel signals

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Quick Facts
Patent No.
US 8,786,624
App. No.
12/792,582
Granted
Jul 22, 2014
Kind
B2
Abstract

Method and apparatus for improved processing for multi-channel signals. In an exemplary embodiment, an anomaly metric is computed for a multi-channel signal over a time window. The magnitude of the anomaly metric may be used to determine whether an anomaly is present in the multi-channel signal over the time window. In an exemplary embodiment, the anomaly metric may be a condition number associated with the singular values of the multi-channel signal over the time window, as further adjusted by the number of channels to produce a data condition number. Applications of the anomaly metric computation include the scrubbing of signal archives for epileptic seizure detection/prediction/counter-prediction algorithm training, pre-processing of multi-channel signals for real-time monitoring of bio-systems, and boot-up and/or adaptive self-checking of such systems during normal operation.

Claims (44)

1. A method for displaying information to a user, the method comprising:

accepting input from the user selecting a metric to be displayed, said selected metric being associated with a multi-channel signal derived from outputs of a plurality of sensors positioned to acquire physiological signals, wherein each channel of the multi-channel signal corresponds to a different one of the plurality of sensors;

displaying with a processor and a computer graphical display interface at least one time-series plot of the selected metric associated with the multi-channel signal;

using a backdrop pattern, indicating on the at least one time-series plot portions of the plot having at least one identified characteristic;

for each of the at least one time-series plot displayed, displaying with the processor and the computer graphical display interface a time event index wherein the corresponding metric meets a predetermined condition, wherein the predetermined condition comprises the selected metric being greater than a predetermined threshold;

accepting input from the user as to whether to display further information associated with the time event index; and

displaying the further information associated with the time event index when the user so specifies.

2. The method of claim 1 , the metric comprising a data condition number calculated for the multi-channel signal.

3. The method of claim 1 , the at least one time-series plot comprising a plurality of time-series plots, each time-series plot associated with a subject ID.

4. The method of claim 1 , the at least one identified characteristic including a portion of the time-series corresponding to a seizure segment.

5. The method of claim 1 , the backdrop pattern comprising a color scheme, the color scheme representing “interictal” segments, “preseizure” segments, “other” segments, “dropouts,” and “seizure” events.

6. The method of claim 1 , the input from the user as to whether to display further information associated with the time event index comprising positioning of a cursor over the time event index.

7. The method of claim 1 , further comprising:

accepting input from the user indicating a color scheme for the backdrop pattern to be used.

8. The method of claim 1 , the displaying the further information associated with the time event index comprising:

displaying a pop-up plot of a portion of the multi-channel signal corresponding to the time event index.

9. The method of claim 8 , the multi-channel signal comprising a multi-channel EEG signal.

10. A method for detecting anomalies in a multi-channel signal, the method comprising:

sampling the multi-channel signal over a time window;

computing with a processor an anomaly metric for the multi-channel signal over the time window; and

identifying the presence of an anomaly based on the magnitude of the anomaly metric; the computing an anomaly metric comprising:

computing a condition number of the multi-channel signal over the time window; and

adjusting the condition number based on a parameter of the multi-channel signal to generate a data condition number (DCN); the multi-channel signal comprising a signal sampled from a plurality of electrodes positioned to acquire physiological signals from a body, the method further comprising:

generating a DCN time series corresponding to a plurality of time windows;

generating an anomaly log based on the DCN time series;

merging anomalies in the anomaly log separated by less than a minimum separation to generate a modified anomaly log;

identifying segments of the multi-channel signal corresponding to anomalies in the modified anomaly log; and

outputting time-expanded versions of the identified segments to a record; the identifying the presence of an anomaly comprising matching the DCN time series to at least one known pattern of DCN time series corresponding to an anomalous condition.

11. A method for detecting anomalies in a multi-channel signal, the method comprising:

sampling the multi-channel signal over a time window;

computing with a processor an anomaly metric for the multi-channel signal over the time window; and

identifying the presence of an anomaly by comparing the magnitude of the anomaly metric to an optimum threshold; the computing an anomaly metric comprising:

computing a condition number of the multi-channel signal over the time window; and

adjusting the condition number based on a parameter of the multi-channel signal to generate a data condition number (DCN); the method further comprising:

generating a DCN time series corresponding to a plurality of time windows;

generating an event log based on the DCN time series, the generating an event log comprising identifying an event as a contiguous set of DCN values greater than a candidate threshold;

merging events in the event log separated by less than a minimum separation to generate a modified event log;

repeating the steps of generating a DCN time series, generating an event log, and merging events using a plurality of candidate thresholds;

generating a plot of number of events identified in a modified event log versus candidate threshold used;

attempting to identify at least one inflection point in the generated plot; and

setting the optimum threshold to be the candidate threshold corresponding to the inflection point with the largest abscissa in the plot.

12. The method of claim 11 , further comprising, when the attempt to identify at least one inflection point is unsuccessful:

identifying a maximum number of events corresponding to a candidate threshold in the histogram; and

setting the optimum threshold to be a candidate threshold whose corresponding number of events is less than or equal to a fixed percentage of the maximum number of events.

Assignments (8)
RELEASE OF SECURITY INTEREST Recorded Sep 20, 2021
From: ACF FINCO I LP
To: LIVANOVA USA, INC.
Reel/Frame 057552/0378 →
SECURITY INTEREST Recorded Aug 16, 2021
From: LIVANOVA USA, INC.
To: GOLDMAN SACHS BANK USA, AS COLLATERAL AGENT
Reel/Frame 057188/0001 →
RELEASE OF SECURITY INTEREST Recorded Aug 16, 2021
From: ARES CAPITAL CORPORATION, AS AGENT FOR THE LENDERS
To: LIVANOVA USA, INC.
Reel/Frame 057189/0001 →
PATENT SECURITY AGREEMENT Recorded Dec 30, 2020
From: LIVANOVA USA, INC.
To: ACF FINCO I LP, AS COLLATERAL AGENT
Reel/Frame 054881/0784 →
PATENT SECURITY AGREEMENT Recorded Jun 17, 2020
From: LIVANOVA USA, INC.
To: ARES CAPITAL CORPORATION, AS COLLATERAL AGENT
Reel/Frame 053673/0675 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 10, 2013
From: NEUROVISTA CORPORATION
To: CYBERONICS, INC.
Reel/Frame 030192/0408 →
SECURITY AGREEMENT Recorded Sep 14, 2012
From: NEUROVISTA CORPORATION
To: CYBERONICS, INC.
Reel/Frame 028959/0395 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 25, 2011
From: ECHAUZ, JAVIER RAMON; SNYDER, DAVID E.; LEYDE, KENT W.
To: NEUROVISTA CORPORATION
Reel/Frame 025693/0181 →