Polymer composites for biomedical applications and methods of making
View Patent ↗A biomedical polymer composite that exhibits ultra-low thermal conductivity properties. In a preferred embodiment, the biomedical polymer composite comprises a base polymer component with a dispersed thermally non-conductive filler component consisting of glass or ceramic nanospheres or microspheres that have a thermal conductivity of less than 5 W/m-K, and preferably less than 2 W/m-K. In one embodiment, the polymer composite has an electrically conductive filler and can be used in a filament for treating arteriovascular malformations. In another embodiment, the polymeric composite can be used as an energy-coupling means to apply energy to tissue.
1. A method of thermally treating tissue in a body, comprising:
selecting a targeted portion of a tissue structure to be ablated using transmitted energy;
identifying a nearby insulation portion of tissue to be insulated from the transmitted energy;
introducing a flowable material into a delivery lumen of an elongate introducer, such that the flowable material flows through the delivery lumen, exits out a distal opening of the elongate introducer, and is deposited onto the insulation portion of tissue, thereby forming an insulative layer on the insulation portion of tissue;
electrically coupling a radiofrequency (RF) energy source to a conductive liquid or gel electrode contacting the targeted portion of the tissue structure;
transmitting RF energy from the RF energy source to the targeted portion of the tissue structure via the conductive liquid or gel electrode to thereby treat at least a portion of the targeted portion of the tissue structure.
2. The method of claim 1 , wherein introducing the flowable material comprises extruding the flowable material through the delivery lumen.
3. The method of claim 2 , wherein extruding comprises manually actuating an extrusion device configured to induce flow of the flowable material out the distal opening of the elongate introducer.
4. The method of claim 1 , wherein the insulative layer comprises a base polymer and a dispersed nonconductive filler.
5. The method of claim 4 , wherein the nonconductive filler comprises hollow microspheres.
6. The method of claim 4 , wherein the base polymer comprises a bio-absorbable material.
7. The method of claim 5 , wherein the hollow microspheres comprise a ceramic or glass.
8. The method of claim 4 , wherein the base polymer is selected from the group consisting of: polyamide, polycarbonate, polystyrene, polyacrylonitrile, polyacetal, thermoplastic modified cellulose, polysulfone, thermoplastic polyester, PET, poly(ethyl acrylate), poly(methyl methacrylate), nylon, fluoropolymer, polyvinylidene fluoride, and ethylene tetrafluoroethylene.
9. The method of claim 1 , wherein the insulative layer has a thermal conductivity of less than about 5 W/m-K.
10. The method of claim 1 , wherein the insulative layer comprises a thermochromic material.