Rejuvenation or preservation of germ cells
View Patent ↗Certain embodiments disclosed herein include, but are not limited to, at least one of compositions, methods, devices, systems, kits, or products regarding rejuvenation or preservation of germ cells or gametes. Certain embodiments disclosed herein include, but are not limited to, methods of modifying germ cells or gametes, or methods of administering modified germ cells or gametes to at least one biological tissue.
1. A modified reproductive cell, produced by the process of actively introducing at least one exogenous energy supplying factor into at least one intracellular compartment of a reproductive cell; and
introducing at least one detection material including at least one of a radioactive, luminescent, colorimetric, fluorescent, odorous substance, sensor, or electronic identification device;
wherein the reproductive cell has not yet entered meiosis.
2. The modified reproductive cell of claim 1 ,
wherein the at least one exogenous energy supplying factor is at least one of exogenous creatine, exogenous phosphocreatine, exogenous chlorophyll, exogenous lactate, or exogenous glucose.
3. The modified reproductive cell of claim 1 ,
wherein the at least one exogenous energy supplying factor is exogenous ATP, exogenous ADP, exogenous AMP, or a precursor thereof.
4. The modified reproductive cell of claim 1 , wherein the reproductive cell is located in situ, in vitro, in vivo, in utero, in planta, or ex vivo.
5. The modified reproductive cell of claim 1 , wherein the reproductive cell is implantable or transplantable.
6. The modified reproductive cell of claim 1 , wherein the reproductive cell is implantable or transplantable into a subject.
7. The modified reproductive cell of claim 6 , wherein the subject is a plant, alga, or animal.
8. The modified reproductive cell of claim 6 , wherein the subject is a vertebrate or invertebrate.
9. The modified reproductive cell of claim 6 , wherein the subject is an amphibian, mammal, reptile, fish, or bird.
10. The modified reproductive cell of claim 6 , wherein the subject is a human.
11. The modified reproductive cell of claim 1 , wherein the reproductive cell is implantable or transplantable into a subject subsequent to modification.
12. A modified reproductive cell, produced by the process of actively introducing at least one exogenous energy supplying factor into at least one intracellular compartment of a reproductive cell; and
introducing at least one detection material including at least one of a radioactive, luminescent, colorimetric, fluorescent, odorous substance, sensor, or electronic identification device;
wherein the reproductive cell has not yet completed mitosis.
13. The modified reproductive cell of claim 12 , wherein the at least one exogenous energy supplying factor is at least one of exogenous creatine, exogenous phosphocreatine, exogenous chlorophyll, exogenous lactate, or exogenous glucose.
14. The modified reproductive cell of claim 12 , wherein the at least one exogenous energy supplying factor is exogenous ATP, exogenous ADP, exogenous AMP, or a precursor thereof.
15. The modified reproductive cell of claim 12 , wherein the reproductive cell is located in situ, in vitro, in vivo, in utero, in planta, or ex vivo.
16. The modified reproductive cell of claim 12 , wherein the reproductive cell is implantable or transplantable into a subject.
17. The modified reproductive cell of claim 16 , wherein the subject is a plant, alga, or animal.
18. The modified reproductive cell of claim 16 , wherein the subject is a vertebrate or invertebrate.
19. The modified reproductive cell of claim 16 , wherein the subject is an amphibian, mammal, reptile, fish, or bird.
20. The modified reproductive cell of claim 16 , wherein the subject is a human.
21. A modified reproductive cell, produced by the process of actively introducing at least one exogenous energy supplying factor into at least one intracellular compartment of a reproductive cell; and
introducing at least one detection material including at least one of a radioactive, luminescent, colorimetric, fluorescent, odorous substance, sensor, or electronic identification device;
wherein the reproductive cell has not yet entered mitosis.
22. The modified reproductive cell of claim 16 , wherein the at least one exogenous energy supplying factor is at least one of exogenous creatine, exogenous phosphocreatine, exogenous chlorophyll, exogenous lactate, or exogenous glucose.
23. The modified reproductive cell of claim 16 , wherein the at least one exogenous energy supplying factor is exogenous ATP, exogenous ADP, exogenous AMP, or a precursor thereof.
24. The modified reproductive cell of claim 21 , wherein the reproductive cell is located in situ, in vitro, in vivo, in utero, in planta, or ex vivo.
25. The modified reproductive cell of claim 21 , wherein the reproductive cell is implantable or transplantable into a subject.
26. The modified reproductive cell of claim 25 , wherein the subject is a plant, alga, or animal.
27. The modified reproductive cell of claim 25 , wherein the subject is a vertebrate or invertebrate.
28. The modified reproductive cell of claim 25 , wherein the subject is an amphibian, mammal, reptile, fish, or bird.
29. The modified reproductive cell of claim 25 , wherein the subject is a human.
30. A modified reproductive cell, produced by the process of actively introducing at least one exogenous energy supplying factor into at least one intracellular compartment of a reproductive cell; and
introducing at least one detection material including at least one of a radioactive, luminescent, colorimetric, fluorescent, odorous substance, sensor, or electronic identification device;
wherein the reproductive cell has not yet completed phase I of meiosis.
31. The modified reproductive cell of claim 30 , wherein the at least one exogenous energy supplying factor is at least one of exogenous creatine, exogenous phosphocreatine, exogenous chlorophyll, exogenous lactate, or exogenous glucose.
32. The modified reproductive cell of claim 30 , wherein the at least one exogenous energy supplying factor is exogenous ATP, exogenous ADP, exogenous AMP, or a precursor thereof.
33. The modified reproductive cell of claim 30 , wherein the reproductive cell is located in situ, in vitro, in vivo, in utero, in planta, or ex vivo.
34. The modified reproductive cell of claim 30 , wherein the reproductive cell is implantable or transplantable into a subject.
35. The modified reproductive cell of claim 34 , wherein the subject is a plant, alga, or animal.
36. The modified reproductive cell of claim 34 , wherein the subject is a vertebrate or invertebrate.
37. The modified reproductive cell of claim 34 , wherein the subject is an amphibian, mammal, reptile, fish, or bird.
38. The modified reproductive cell of claim 34 , wherein the subject is a human.