Enhanced erythropoiesis and iron metabolism
The present invention relates to methods and compounds for decreasing the expression of hepcidin, a protein associated with regulation of iron metabolism.
1. A method for decreasing hepcidin expression in a subject in need thereof, the method comprising administering to the subject an effective amount of a heterocyclic carboxamide compound that stabilizes the alpha subunit of hypoxia-inducible factor (HIFα), thereby decreasing hepcidin expression in the subject.
2. The method of claim 1 , wherein the heterocyclic carboxamide compound is a heterocyclic carbonyl glycine compound.
3. The method of claim 1 , wherein the subject is a subject having anemia.
4. The method of claim 3 , wherein the anemia is anemia of chronic disease.
5. The method of claim 1 , wherein the subject is a subject having a chronic disease selected from the group consisting of an inflammation, an infection, an immunodeficiency disorder, and a neoplastic disorder.
6. The method of claim 1 , wherein the subject is a subject having iron deficiency.
7. The method of claim 6 , wherein the iron deficiency is functional iron deficiency.
8. The method of claim 1 , wherein the heterocyclic carboxamide compound inhibits hypoxia-inducible factor prolyl hydroxylase enzyme activity.
9. The method of claim 1 , wherein the heterocyclic carboxamide compound is a structural mimetic of 2-oxoglutarate.