Enhanced erythropoiesis and iron metabolism
The present invention relates to methods for increasing iron absorption in a subject by administering to the subject an effective amount of a compound that inhibits hypoxia-inducible factor prolyl hydroxylase activity.
1. A method for increasing iron absorption in a subject in need thereof, the method comprising administering to the subject an effective amount of a heterocyclic carboxamide compound that stabilizes the alpha subunit of hypoxia-inducible factor (HIFα), thereby increasing iron absorption in the subject.
2. The method of claim 1 , wherein the heterocyclic carboxamide compound is a heterocyclic carbonyl glycine compound.
3. The method of claim 1 , wherein the iron absorption is intestinal iron absorption.
4. The method of claim 1 , wherein the iron absorption is absorption of dietary iron.
5. The method of claim 1 , wherein the subject is a subject having a chronic disease selected from the group consisting of an inflammation, an infection, an immunodeficiency disorder, and a neoplastic disorder.
6. The method of claim 1 , wherein the subject is a subject having anemia.
7. The method of claim 6 , wherein the anemia is anemia of chronic disease.
8. The method of claim 1 , wherein the heterocyclic carboxamide compound inhibits hypoxia-inducible factor prolyl hydroxylase enzyme activity.
9. The method of claim 1 , wherein the heterocyclic carboxamide compound is a structural mimetic of 2-oxoglutarate.
10. The method of claim 1 , wherein the subject is a subject having iron deficiency.
11. The method of claim 10 , wherein the iron deficiency is functional iron deficiency.