Adhesive laminates for rapid wound occlusion
View Patent ↗Provided herein are protective laminate devices comprising a biocompatible non-adherent substance and a fast-setting adhesive and methods of use. Also provided is a dispenser for an adhesive tape. The protective laminate devices and methods may be used for wound closure.
1. A laminate device for protecting an adhesive during manipulation thereof, comprising:
a continuous layer of cyanoacrylate adhesive; and
at least one layer of a biocompatible non-adherent substance disposed in protective and covering relationship to the cyanoacrylate adhesive.
2. The laminate device of claim 1 , wherein one or more layers of the biocompatible non-adherent substance further comprises an emulsifying agent, a solubilizing agent, a wetting agent, a taste modifying agent, a plasticizer, a bioactive agent, a water soluble inert filler, a preservative, a buffering agent, a coloring agent, a stabilizer, or a combination thereof.
3. The laminate device of claim 1 , wherein one or more layers of said biocompatible non-adherent substance further comprises a pharmaceutical.
4. The laminate device of claim 3 , wherein the pharmaceutical is contained within a rupturable reservoir within said layer(s).
5. The laminate device of claim 1 , wherein the layer(s) of the biocompatible non-adherent substance is disposed on one or both surfaces of the continuous cyanoacrylate adhesive layer.
6. The laminate device of claim 1 , wherein the biocompatible non-adherable protective substance is dissolvable upon contact with a fluid.
7. The laminate device of claim 6 , wherein the fluid is water.
8. The laminate device of claim 1 , wherein one or more layers of the biocompatible non-adherent substance comprises a hydrocolloid.
9. The laminate device of claim 8 , wherein the hydrocolloid is pullulan.
10. The laminate device of claim 1 , further comprising at least one removable layer disposed in contact with the cyanoacrylate adhesive, with one or more layers of the biocompatible non-adherent substance or a combination thereof.
11. The laminate device of claim 10 , wherein the removable layer is disposed in contact with the cyanoacrylate adhesive, said removable layer removable prior to manipulation of the cyanoacrylate adhesive.
12. The laminate device of claim 10 , wherein the removable layer is disposed between the cyanoacrylate adhesive and the biocompatible non-adherent substance or is disposed in covering relationship to an outer layer of the biocompatible non-adherent substance, said removable layer removable after manipulation of the cyanoacrylate adhesive.
13. The laminate device of claim 10 , wherein the removable layer comprises a polymer, Polytetrafluorethylene (PTFE) or a cellulose impregnated with a lipid.
14. The laminate device of claim 13 , wherein the lipid is a lecithin, polyethylene glycol or a wax.
15. The laminate device of claim 1 , wherein the device comprises a patch.