IP Library › Granted Patent US 8,394,141
Granted Patent B2
US 8,394,141 · App. 12/807,599 · Granted Mar 12, 2013

Connective-tissue-based or dermal-tissue-based grafts/implants

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Quick Facts
Patent No.
US 8,394,141
App. No.
12/807,599
Granted
Mar 12, 2013
Kind
B2
Abstract

The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic gent to attract a desired cell.

Claims (12)

1. An implant comprising a matrix suitable for implantation in humans, comprising a porous matrix that is formed from the fibers of defatted, shredded, allogeneic human tissue;

wherein the matrix is formed in a predetermined shape and has a water content less than 3%; and

wherein said predetermined shape is a strip; and

wherein said implant has the property of holding its shape during rehydration and handling.

2. The implant of claim 1 , wherein the allogenic human tissue is tendon, fascia, ligament or dermis.

3. The implant of claim 1 , wherein the implant further comprises seeded cells, a tissue growth factor, a chemotactic agent, or a combination thereof.

4. The implant of claim 1 , wherein the implant further comprises particles of demineralized bone matrix (DBM), mineralized bone matrix, cortical cancellous chips (CCC), crushed cancellous chips, tricalcium phosphate, hydroxyapatite, or biphasic calcium phosphate dispersed in the matrix.

5. The implant of claim 4 , wherein the implant further comprises a therapeutically effective amount of a growth factor selected from the group consisting of bone morphogenic protein (BMP), LIM mineralization protein (LMP) and RUNX-2.

6. The implant of claim 4 , wherein the porous matrix has a layered structure, and wherein the demineralized bone matrix (DBM), mineralized bone matrix, cortical cancellous chips (CCC), crushed cancellous chips, tricalcium phosphate, hydroxyapatite, or biphasic calcium phosphate are sandwiched between layers of the porous matrix to form a laminate implant.

7. The implant of claim 1 , wherein the implant further comprises a growth factor suitable for inducing the growth of fibroblasts, melanocytes, osteogenic cells, stem cells, skin cells or a combination thereof.

8. The implant of claim 3 , wherein said seeded cells are fibroblasts, melanocytes, osteogenic cells, stem cells, skin cells or a combination thereof.

9. The implant of claim 1 , which has been treated to remove or neautralize antigenic proteins, bacteria and viruses.

Assignments (15)
TERMINATION AND RELEASE OF SECURITY INTEREST IN PATENTS AND TRADEMARKS Recorded Sep 25, 2025
From: ARES CAPITAL CORPORATION
To: RTI SURGICAL INC. D/B/A EVERGEN
Reel/Frame 072938/0203 →
RELEASE OF SECURITY INTEREST Recorded Jul 21, 2020
From: JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT
To: RTI SURGICAL, INC.; PIONEER SURGICAL TECHNOLOGY, INC.; TUTOGEN MEDICAL, INC.
Reel/Frame 053260/0398 →
SECURITY INTEREST Recorded Jul 21, 2020
From: RTI SURGICAL, INC.; PIONEER SURGICAL TECHNOLOGY, INC.; TUTOGEN MEDICAL (UNITED STATES), INC.
To: ARES CAPITAL CORPORATION, AS SECURITY AGENT
Reel/Frame 053273/0665 →
CHANGE OF NAME Recorded Jul 20, 2020
From: RTI OEM, LLC
To: RTI SURGICAL, INC.
Reel/Frame 053259/0146 →
INTELLECTUAL PROPERTY ASSIGNMENT AGREEMENT Recorded Jul 20, 2020
From: SURGALIGN SPINE TECHNOLOGIES, INC. (FORMERLY KNOWN AS RTI SURGICAL, INC.)
To: RTI OEM, LLC
Reel/Frame 053259/0019 →
CHANGE OF NAME Recorded Jul 20, 2020
From: RTI SURGICAL, INC.
To: SURGALIGN SPINE TECHNOLOGIES, INC.
Reel/Frame 053248/0432 →
RELEASE OF SECURITY INTEREST Recorded Jul 20, 2020
From: ARES CAPITAL CORPORATION, AS AGENT
To: RTI SURGICAL, INC.; PIONEER SURGICAL TECHNOLOGY, INC.; TUTOGEN MEDICAL, INC.; PARADIGM SPINE, LLC; FOURTH DIMENSION SPINE, LLC
Reel/Frame 053257/0652 →
SECURITY INTEREST Recorded Mar 8, 2019
From: RTI SURGICAL, INC.; PIONEER SURGICAL TECHNOLOGY, INC.; TUTOGEN MEDICAL, INC.; PARADIGM SPINE, LLC; FOURTH DIMENSION SPINE, LLC
To: ARES CAPITAL CORPORATION, AS ADMINISTRATIVE AGENT
Reel/Frame 048543/0505 →
RELEASE OF SECURITY INTEREST Recorded Jun 7, 2018
From: TD BANK, N.A., AS ADMINISTRATIVE AGENT
To: RTI SURGICAL, INC.
Reel/Frame 046327/0184 →
RELEASE OF SECURITY INTEREST Recorded Jun 7, 2018
From: TD BANK, N.A., AS ADMINISTRATIVE AGENT
To: RTI SURGICAL, INC.
Reel/Frame 046327/0864 →
SECURITY INTEREST Recorded Jun 6, 2018
From: RTI SURGICAL, INC.; PIONEER SURGICAL TECHNOLOGY, INC.; TUTOGEN MEDICAL, INC.
To: JPMORGAN CHASE BANK, N.A., AS THE ADMINISTRATIVE AGENT
Reel/Frame 046303/0926 →
SECURITY INTEREST Recorded Aug 20, 2017
From: RTI SURGICAL, INC.
To: TD BANK, N.A.
Reel/Frame 043608/0874 →
CHANGE OF NAME Recorded Aug 14, 2013
From: RTI BIOLOGICS, INC.
To: RTI SURGICAL, INC.
Reel/Frame 031012/0159 →
SECURITY AGREEMENT Recorded Jul 26, 2013
From: RTI SURGICAL, INC.
To: TD BANK, N.A., AS ADMINISTRATIVE AGENT
Reel/Frame 030888/0001 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 24, 2012
From: MILLS, C. RANDAL; BIANCHI, JOHN R.; ROBERTS, MICHAEL R.; CHEUNG, DAVID T.; NATARAJ, CHANDRASEKARAN; HOWELL, JOHN W., JR.
To: RTI BIOLOGICS, INC.
Reel/Frame 028099/0415 →