Aminopyrazole derivatives

1. A compound of formula (I),

wherein

A represents a phenyl- or a monocyclic heterocyclyl-group, wherein the phenyl- or monocyclic heterocyclyl-group is substituted in a 1,3-arrangement; or A represents propan-1,3-diyl;

E represents *-(C 1 -C 4 )alkyl-O—, —CH═CH— or

wherein the asterisks indicate the bond which is linked to R 1 ;

Q represents O, or S;

R 3 represents hydrogen, (C 1 -C 4 )alkyl, cyclopropyl, (C 1 -C 4 )alkoxy-(C 1 -C 2 )alkyl, —CH 2 NH 2 , —CH 2 NHBoc, —CH 2 CH 2 C(O)OtBu or benzyl;

R 1 represents a heterocyclyl- or an aryl-group, which group is unsubstituted, mono-, di- or tri-substituted, with

halogen, (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )fluoroalkyl, (C 1 -C 4 )fluoroalkoxy, phenyl, cyano, di-[(C 1 -C 3 )alkyl]-amino, —C(O)—NH 2 , —C(O)OtBu, (C 1 -C 4 )alkoxy-(C 1 -C 2 )alkyl, hydroxy-(C 1 -C 2 )alkyl or dimethylamino-(C 1 -C 2 )alkyl; and

R 2 represents —CO—(C 1 -C 3 )alkyl, —CO-cyclopropyl, —CF 2 —(C 1 -C 3 )alkyl, —CHF—(C 1 -C 3 )alkyl or —SO 2 —(C 1 -C 3 )alkyl;

or a salt thereof.

2. The compound of claim 1 , wherein A represents furan-2,5-diyl, oxazol-2,4-diyl, oxazol-2,5-diyl, thiophen-2,4-diyl, thiophen-2,5-diyl, thiazol-2,4-diyl or pyridin-2,4-diyl;

or a salt thereof.

3. The compound of claim 1 , wherein A represents propan-1,3-diyl;

or a salt thereof.

4. The compound of claim 1 , wherein E represents

or a salt thereof.

5. The compound of claim 1 , wherein E represents *-(C 1 -C 4 )alkyl-O— or —CH═CH—;

or a salt thereof.

6. The compound of claim 4 , wherein Q represents O; or a salt thereof.

7. The compound of claim 1 , wherein R 3 represents hydrogen or methyl;

or a salt thereof.

8. The compound of claim 1 , wherein R 1 represents phenyl, which is unsubstituted, mono-, di- or tri-substituted with halogen, (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )fluoroalkyl, (C 1 -C 4 )fluoroalkoxy, phenyl, cyano, dimethylamino, —C(O)OtBu or (C 1 -C 4 )alkoxy-(C 1 -C 2 )alkyl;

or a salt thereof.

9. The compound of claim 1 , wherein R 2 represents —CO—(C 1 -C 3 )alkyl or —CF 2 —(C 1 -C 3 )alkyl; or a salt thereof.

10. The compound of claim 1 , wherein the compound is:

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 2-chloro-benzyl ester;

[1-(5-Propionyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 2-chloro-benzyl ester;

[1-(5-Cyclopropanecarbonyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 2-chloro-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-carbamic acid benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-carbamic acid 2-methyl-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-carbamic acid 4-trifluoromethyl-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-carbamic acid 3-trifluoromethyl-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-carbamic acid 3-chloro-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-carbamic acid 2-chloro-4-fluoro-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-carbamic acid 2-ethyl-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-carbamic acid 2,6-dichloro-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-carbamic acid 3,4-dimethyl-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-carbamic acid 3,4-difluoro-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-carbamic acid 2-chloro-6-fluoro-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-carbamic acid naphthalen-1-ylmethyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-carbamic acid 2,5-dimethyl-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-carbamic acid 2,4,6-trifluoro-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-carbamic acid 2,3-difluoro-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-carbamic acid 3-chloro-2,6-difluoro-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-carbamic acid 6-chloro-2-fluoro-3-methyl-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-carbamic acid 3-chloro-2-fluoro-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-carbamic acid 2-chloro-6-fluoro-3-methyl-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-carbamic acid 2,4,5-trifluoro-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-carbamic acid 2,3,4-trifluoro-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-carbamic acid 4-bromo-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-carbamic acid 2-trifluoromethyl-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-carbamic acid 2-fluoro-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-carbamic acid 4-chloro-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-carbamic acid 3-methyl-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-carbamic acid 2,6-difluoro-3-methyl-benzyl ester;

5-Phenyl-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-3-phenyl-acrylamide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-3-(2-trifluoromethyl-phenyl)-acrylamide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-3-(4-trifluoromethyl-phenyl)-acrylamide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-3-(2-chloro-6-fluoro-phenyl)-acrylamide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-3-(2,3-dimethoxy-phenyl)-acrylamide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-3-(2,3-dichloro-phenyl)-acrylamide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-3-(3-trifluoromethoxy-phenyl)-acrylamide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-3-(3-chloro-4-fluoro-phenyl)-acrylamide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-3-(2-chloro-3,6-difluoro-phenyl)-acrylamide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-3-(2,4-dichloro-phenyl)-acrylamide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-3-(2-chloro-4-fluoro-phenyl)-acrylamide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-3-(2-methoxy-phenyl)-acrylamide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-3-(2-fluoro-3-trifluoromethyl-phenyl)-acrylamide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-3-o-tolyl-acrylamide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-3-(3-chloro-phenyl)-acrylamide;

5-(4-Methoxy-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

2-Methyl-5-m-tolyl-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-3-(3-trifluoromethyl-phenyl)-acrylamide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-3-(4-methoxy-phenyl)-acrylamide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-3-p-tolyl-acrylamide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-3-(3-methoxy-phenyl)-acrylamide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-3-m-tolyl-acrylamide;

5-(3-Methoxy-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

5-(4-Methoxy-phenyl)-2-methyl-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

2-Methyl-5-o-tolyl-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 2-methyl-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]carbamic acid 4-trifluoromethyl-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 3-trifluoromethyl-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 3-chloro-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 2-chloro-4-fluoro-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 2-ethyl-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 2,6-dichloro-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 3,4-dimethyl-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 3,4-difluoro-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 2-chloro-6-fluoro-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid naphthalen-1-ylmethyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 2,5-dimethyl-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 2,4,6-trifluoro-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 2,3-difluoro-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 3-chloro-2,6-difluoro-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 6-chloro-2-fluoro-3-methyl-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 3-chloro-2-fluoro-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 2-chloro-6-fluoro-3-methyl-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 2,4,5-trifluoro-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 2,6-difluoro-3-methyl-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 2,3,4-trifluoro-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 4-bromo-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 2-trifluoromethyl-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 2-fluoro-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 4-chloro-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]carbamic acid 3-methyl-benzyl ester;

5-Phenyl-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-3-(2-trifluoromethyl-phenyl)-acrylamide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-3-(4-trifluoromethyl-phenyl)-acrylamide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-3-(2-chloro-6-fluoro-phenyl)-acrylamide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-3-(2,3-dimethoxy-phenyl)-acrylamide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-3-(2,3-dichloro-phenyl)-acrylamide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-3-(3-trifluoromethoxy-phenyl)-acrylamide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-3-(2-chloro-3,6-difluoro-phenyl)-acrylamide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-3-(2,4-dichloro-phenyl)-acrylamide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-3-(2-chloro-4-fluoro-phenyl)-acrylamide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-3-o-tolyl-acrylamide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-3-(3-chloro-phenyl)-acrylamide;

5-(4-Methoxy-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

2-Methyl-5-m-tolyl-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl] amide;

5-(4-Methoxy-phenyl)-2-methyl-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

2-Methyl-5-m-tolyl-thiazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-3-(3-trifluoromethyl-phenyl)-acrylamide;

5-(3-Methoxy-phenyl)-2-methyl-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

2-Methyl-5-phenyl-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-3-(2-chloro-phenyl)-acrylamide;

5-m-Tolyl-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-3-p-tolyl-acrylamide;

5-(3-Methoxy-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

2-Methyl-5-o-tolyl-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

5-(3-Chloro-phenyl)-thiazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

5-(2-Fluoro-phenyl)-thiazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

[1-(5-Oxo-hexyl)-1H-pyrazol-4-yl]-carbamic acid 2-chloro-benzyl ester;

[1-(5-Oxo-hexyl)-1H-pyrazol-4-yl]-carbamic acid 1-phenyl-ethyl ester;

[1-(5-Oxo-hexyl)-1H-pyrazol-4-yl]-carbamic acid 4-bromo-benzyl ester;

[1-(5-Oxo-hexyl)-1H-pyrazol-4-yl]-carbamic acid 2-trifluoromethyl-benzyl ester;

[1-(5-Oxo-hexyl)-1H-pyrazol-4-yl]-carbamic acid 2-fluoro-benzyl ester;

[1-(5-Oxo-hexyl)-1H-pyrazol-4-yl]-carbamic acid 4-chloro-benzyl ester;

[1-(5-Oxo-hexyl)-1H-pyrazol-4-yl]-carbamic acid 3-methyl-benzyl ester;

[1-(5-Oxo-hexyl)-1H-pyrazol-4-yl]-carbamic acid 3-trifluoromethyl-benzyl ester;

[1-(5-Oxo-hexyl)-1H-pyrazol-4-yl]-carbamic acid 3-chloro-benzyl ester;

[1-(5-Oxo-hexyl)-1H-pyrazol-4-yl]-carbamic acid 2-chloro-4-fluoro-benzyl ester;

[1-(5-Oxo-hexyl)-1H-pyrazol-4-yl]-carbamic acid 2-ethyl-benzyl ester;

[1-(5-Oxo-hexyl)-1H-pyrazol-4-yl]-carbamic acid 2,6-dichloro-benzyl ester;

[1-(5-Oxo-hexyl)-1H-pyrazol-4-yl]-carbamic acid 3,4-dimethyl-benzyl ester;

[1-(5-Oxo-hexyl)-1H-pyrazol-4-yl]-carbamic acid 3,4-difluoro-benzyl ester;

[1-(5-Oxo-hexyl)-1H-pyrazol-4-yl]-carbamic acid naphthalen-1-ylmethyl ester;

[1-(5-Oxo-hexyl)-1H-pyrazol-4-yl]-carbamic acid 2,5-dimethyl-benzyl ester;

[1-(5-Oxo-hexyl)-1H-pyrazol-4-yl]-carbamic acid 2,4,6-trifluoro-benzyl ester;

[1-(5-Oxo-hexyl)-1H-pyrazol-4-yl]-carbamic acid 2,3-difluoro-benzyl ester;

[1-(5-Oxo-hexyl)-1H-pyrazol-4-yl]-carbamic acid 3-chloro-2,6-difluoro-benzyl ester;

[1-(5-Oxo-hexyl)-1H-pyrazol-4-yl]-carbamic acid 6-chloro-2-fluoro-3-methyl-benzyl ester;

[1-(5-Oxo-hexyl)-1H-pyrazol-4-yl]-carbamic acid 3-chloro-2-fluoro-benzyl ester;

[1-(5-Oxo-hexyl)-1H-pyrazol-4-yl]-carbamic acid 2-chloro-6-fluoro-3-methyl-benzyl ester;

[1-(5-Oxo-hexyl)-1H-pyrazol-4-yl]-carbamic acid 2,6-difluoro-3-methyl-benzyl ester;

[1-(5-Oxo-hexyl)-1H-pyrazol-4-yl]-carbamic acid 2-fluoro-5-trifluoromethyl-benzyl ester;

[1-(5-Oxo-hexyl)-1H-pyrazol-4-yl]-carbamic acid 2,3,5-trifluoro-benzyl ester;

[1-(5-Oxo-hexyl)-1H-pyrazol-4-yl]-carbamic acid 2,3,4-trifluoro-benzyl ester;

5-Phenyl-oxazole-4-carboxylic acid [1-(5-oxo-hexyl)-1H-pyrazol-4-yl]-amide;

(E)-N-[1-(5-oxo-hexyl)-1H-pyrazol-4-yl]-3-(2-trifluoromethyl-phenyl)-acrylamide;

(E)-N-[1-(5-oxo-hexyl)-1H-pyrazol-4-yl]-3-o-tolyl-acrylamide;

(E)-3-(2-Chloro-phenyl)-N-[1-(5-oxo-hexyl)-1H-pyrazol-4-yl]-acrylamide;

2-Methyl-5-m-tolyl-oxazole-4-carboxylic acid [1-(5-oxo-hexyl)-1H-pyrazol-4-yl]-amide;

[1-(5-Oxo-hexyl)-1H-pyrazol-3-yl]-carbamic acid 2-chloro-benzyl ester;

[1-(5-Oxo-hexyl)-1H-pyrazol-3-yl]-carbamic acid benzyl ester;

[1-(5-Oxo-hexyl)-1H-pyrazol-3-yl]-carbamic acid 2-methyl-benzyl ester;

[1-(5-Oxo-hexyl)-1H-pyrazol-3-yl]-carbamic acid 3-trifluoromethyl-benzyl ester;

[1-(5-Oxo-hexyl)-1H-pyrazol-3-yl]-carbamic acid 3-chloro-benzyl ester;

[1-(5-Oxo-hexyl)-1H-pyrazol-3-yl]-carbamic acid 2-chloro-4-fluoro-benzyl ester;

[1-(5-Oxo-hexyl)-1H-pyrazol-3-yl]-carbamic acid 3,4-dimethyl-benzyl ester;

[1-(5-Oxo-hexyl)-1H-pyrazol-3-yl]-carbamic acid 3,4-difluoro-benzyl ester;

[1-(5-Oxo-hexyl)-1H-pyrazol-3-yl]-carbamic acid 2-chloro-6-fluoro-benzyl ester;

[1-(5-Oxo-hexyl)-1H-pyrazol-3-yl]-carbamic acid naphthalen-1-ylmethyl ester;

[1-(5-Oxo-hexyl)-1H-pyrazol-3-yl]-carbamic acid 2,5-dimethyl-benzyl ester;

[1-(5-Oxo-hexyl)-1H-pyrazol-3-yl]-carbamic acid 2,3-difluoro-benzyl ester;

[1-(5-Oxo-hexyl)-1H-pyrazol-3-yl]-carbamic acid 6-chloro-2-fluoro-3-methyl-benzyl ester;

[1-(5-Oxo-hexyl)-1H-pyrazol-3-yl]-carbamic acid 3-chloro-2-fluoro-benzyl ester;

[1-(5-Oxo-hexyl)-1H-pyrazol-3-yl]-carbamic acid 2-chloro-6-fluoro-3-methyl-benzyl ester;

[1-(5-Oxo-hexyl)-1H-pyrazol-3-yl]carbamic acid 2,6-difluoro-3-methyl-benzyl ester;

[1-(5-Oxo-hexyl)-1H-pyrazol-3-yl]-carbamic acid 2-ethyl-benzyl ester;

5-Phenyl-oxazole-4-carboxylic acid [1-(5-oxo-hexyl)-1H-pyrazol-3-yl]-amide;

(E)-N-[1-(5-oxo-hexyl)-1H-pyrazol-3-yl]-3-(2-trifluoromethyl-phenyl)-acrylamide;

(E)-N-[1-(5-oxo-hexyl)-1H-pyrazol-3-yl]-3-(4-trifluoromethyl-phenyl)-acrylamide;

(E)-3-(2,3-Dichloro-phenyl)-N-[1-(5-oxo-hexyl)-1H-pyrazol-3-yl]-acrylamide;

(E)-3-(2,4-Dichloro-phenyl)-N-[1-(5-oxo-hexyl)-1H-pyrazol-3-yl]-acrylamide;

(E)-3-(2-Chloro-4-fluoro-phenyl)-N-[1-(5-oxo-hexyl)-1H-pyrazol-3-yl]-acrylamide;

(E)-N-[1-(5-oxo-hexyl)-1H-pyrazol-3-yl]-3-o-tolyl-acrylamide;

2-Methyl-5-m-tolyl-oxazole-4-carboxylic acid [1-(5-oxo-hexyl)-1H-pyrazol-3-yl]-amide;

(E)-3-(3-Chloro-phenyl)-N-[1-(5-oxo-hexyl)-1H-pyrazol-3-yl]-acrylamide;

{1-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-3-yl}-carbamic acid 2-chloro-benzyl ester;

5-Phenyl-oxazole-4-carboxylic acid {1-[5-(1,1-difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-3-yl}-amide;

{1-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-4-yl}-carbamic acid 2-chloro-benzyl ester;

5-Phenyl-oxazole-4-carboxylic acid {1-[5-(1,1-difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-4-yl}-amide;

[1-(5,5-Difluoro-hexyl)-1H-pyrazol-3-yl]-carbamic acid 2-chloro-benzyl ester;

5-Phenyl-oxazole-4-carboxylic acid [1-(5,5-difluoro-hexyl)-1H-pyrazol-3-yl]-amide;

[1-(5,5-Difluoro-hexyl)-1H-pyrazol-4-yl]-carbamic acid 2-chloro-benzyl ester;

5-Phenyl-oxazole-4-carboxylic acid [1-(5,5-difluoro-hexyl)-1H-pyrazol-4-yl]-amide;

2-Cyclopropyl-5-phenyl-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

2-Ethyl-5-phenyl-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

{1-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-3-yl}-carbamic acid 6-chloro-2-fluoro-3-methyl-benzyl ester;

{1-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-3-yl-}carbamic acid 2-chloro-6-fluoro-3-methyl-benzyl ester;

[1-(5,5-Difluoro-hexyl)-1H-pyrazol-3-yl]-carbamic acid 2-chloro-6-fluoro-3-methyl-benzyl ester;

[1-(5,5-Difluoro-hexyl)-1H-pyrazol-3-yl]-carbamic acid 6-chloro-2-fluoro-3-methyl-benzyl ester;

2-Methyl-5-phenyl-oxazole-4-carboxylic acid [1-(5,5-difluoro-hexyl)-1H-pyrazol-4-yl]-amide;

2-Methyl-5-m-tolyl-oxazole-4-carboxylic acid [1-(5,5-difluoro-hexyl)-1H-pyrazol-4-yl]-amide;

(E)-N-[1-(5,5-Difluoro-hexyl)-1H-pyrazol-3-yl]-3-(4-trifluoromethyl-phenyl)-acrylamide;

(E)-N-[1-(5,5-Difluoro-hexyl)-1H-pyrazol-3-yl]-3-(2-trifluoromethyl-phenyl)-acrylamide;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]carbamic acid 2-chloro-benzyl ester;

[1-(5-Fluoro-hexyl)-1H-pyrazol-4-yl]-carbamic acid 2-chloro-benzyl ester;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-3-(2-chloro-phenyl)-acrylamide;

{1-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-4-yl}-carbamic acid 6-chloro-2-fluoro-3-methyl-benzyl ester;

{1-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-4-yl}-carbamic acid 2-chloro-6-fluoro-3-methyl-benzyl ester;

[1-(5,5-Difluoro-hexyl)-1H-pyrazol-4-yl]-carbamic acid 2-chloro-6-fluoro-3-methyl-benzyl ester;

[1-(5,5-Difluoro-hexyl)-1H-pyrazol-4-yl]-carbamic acid 6-chloro-2-fluoro-3-methyl-benzyl ester;

5-m-Tolyl-oxazole-4-carboxylic acid {1-[5-(1,1-difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-4-yl}-amide;

5-(4-Methoxy-phenyl)-oxazole-4-carboxylic acid {1-[5-(1,1-difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-4-yl}-amide;

5-(4-Methoxy-phenyl)-2-methyl-oxazole-4-carboxylic acid {1-[5-(1,1-difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-4-yl}-amide;

(E)-N-{1-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-4-yl}-3-(4-trifluoromethyl-phenyl)-acrylamide;

(E)-N-{1-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-4-yl}-3-(2,3-dimethoxy-phenyl)-acrylamide;

(E)-N-{1-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-4-yl}-3-p-tolyl-acrylamide;

5-(3-Methoxy-phenyl)-2-methyl-oxazole-4-carboxylic acid {1-[5-(1,1-difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-4-yl}-amide;

5-(3-Chloro-phenyl)-thiazole-4-carboxylic acid {1-[5-(1,1-difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-4-yl}-amide;

(E)-N-{1-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-4-yl}-3-(4-methoxy-phenyl)-acrylamide;

(E)-N-{1-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-3-yl}-3-(3-trifluoromethyl-phenyl)-acrylamide;

(E)-3-(2,3-Dichloro-phenyl)-N-{1-[5-(1,1-difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-3-yl}-acrylamide;

(E)-N-{1-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-3-yl}-3-(2,3-dimethoxy-phenyl)-acrylamide;

(E)-3-(2-Chloro-4-fluoro-phenyl)-N-{1-[5-(1,1-difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-3-yl}-acrylamide;

(E)-N-{1-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-3-yl}-3-p-tolyl-acrylamide;

(E)-3-(2,4-Dichloro-phenyl)-N-{1-[5-(1,1-difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-3-yl}-acrylamide;

(E)-3-(2-Chloro-6-fluoro-phenyl)-N-{1-[5-(1,1-difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-3-yl}-acrylamide;

(E)-3-(2-Chloro-3,6-difluoro-phenyl)-N-{1-[5-(1,1-difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-3-yl}-acrylamide;

(E)-3-(3-Chloro-phenyl)-N-{1-[5-(1,1-difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-3-yl}-acrylamide;

(E)-N-{1-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-3-yl}-3-(2-fluoro-3-trifluoromethyl-phenyl)-acrylamide;

(E)-N-{1-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-3-yl}-3-m-tolyl-acrylamide;

(E)-N-{1-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-3-yl}-3-(3-methoxy-phenyl)-acrylamide;

(E)-N-{1-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-3-yl}-3-(4-methoxy-phenyl)-acrylamide;

2-Methyl-5-phenyl-oxazole-4-carboxylic acid {1-[5-(1,1-difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-4-yl}-amide;

2-Methyl-5-m-tolyl-oxazole-4-carboxylic acid {1-[5-(1,1-difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-4-yl}-amide;

2-Methyl-5-m-tolyl-oxazole-4-carboxylic acid {1-[5-(1,1-difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-3-yl}-amide;

5-(3-Methoxy-phenyl)-2-methyl-oxazole-4-carboxylic acid {1-[5-(1,1-difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-3-yl}-amide;

5-(3-Methoxy-phenyl)-oxazole-4-carboxylic acid {1-[5-(1,1-difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-4-yl}-amide;

5-(3-Methoxy-phenyl)-oxazole-4-carboxylic acid {1-[5-(1,1-difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-3-yl}-amide;

5-(4-Methoxy-phenyl)-oxazole-4-carboxylic acid {1-[5-(1,1-difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-3-yl}-amide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-3-(2-trifluoromethyl-phenyl)-acrylamide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-3-(4-trifluoromethyl-phenyl)-acrylamide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-3-(2-trifluoromethyl-phenyl)-acrylamide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-3-(4-trifluoromethyl-phenyl)-acrylamide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-3-(4-methoxy-phenyl)-acrylamide;

{1-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-4-yl}-carbamic acid 3-chloro-2-fluoro-benzyl ester;

{1-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-3-yl}-carbamic acid 3-trifluoromethyl-benzyl ester;

{1-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-4-yl}-carbamic acid 2-chloro-4-fluoro-benzyl ester;

[1-(5,5-Difluoro-hexyl)-1H-pyrazol-3-yl]-carbamic acid 2,6-difluoro-3-methyl-benzyl ester;

{1-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-4-yl}-carbamic acid 2-chloro-6-fluoro-benzyl ester;

{1-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-3-yl}-carbamic acid 2-fluoro-benzyl ester;

[1-(5,5-Difluoro-hexyl)-1H-pyrazol-3-yl]-carbamic acid 3-trifluoromethyl-benzyl ester;

{1-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-3-yl}-carbamic acid 3-chloro-benzyl ester;

[1-(5,5-Difluoro-hexyl)-1H-pyrazol-4-yl]-carbamic acid 3-trifluoromethyl-benzyl ester;

{1-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-4-yl}-carbamic acid 2,6-difluoro-3-methyl-benzyl ester;

{1-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-4-yl}-carbamic acid 2-fluoro-benzyl ester;

[1-(5,5-Difluoro-hexyl)-1H-pyrazol-3-yl]-carbamic acid 2-fluoro-benzyl ester;

{1-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-3-yl}-carbamic acid benzyl ester;

{1-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-4-yl}-carbamic acid 3-trifluoromethyl-benzyl ester;

[1-(5,5-Difluoro-hexyl)-1H-pyrazol-4-yl]-carbamic acid 2-fluoro-benzyl ester;

[1-(5,5-Difluoro-hexyl)-1H-pyrazol-3-yl]-carbamic acid 3-chloro-benzyl ester;

[1-(5,5-Difluoro-hexyl)-1H-pyrazol-3-yl]-carbamic acid 3,4-dimethyl-benzyl ester;

[1-(5,5-Difluoro-hexyl)-1H-pyrazol-3-yl]-carbamic acid 2-ethyl-benzyl ester;

{1-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-3-yl}-carbamic acid 3-methyl-benzyl ester;

[1-(5,5-Difluoro-hexyl)-1H-pyrazol-4-yl]carbamic acid 3-chloro-benzyl ester;

{1-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-3-yl}-carbamic acid 2-ethyl-benzyl ester;

{1-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-4-yl}-carbamic acid benzyl ester;

[1-(5,5-Difluoro-hexyl)-1H-pyrazol-3-yl]carbamic acid benzyl ester;

[1-(5,5-Difluoro-hexyl)-1H-pyrazol-4-yl]-carbamic acid 3,4-dimethyl-benzyl ester;

{1-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-4-yl}-carbamic acid 2-methyl-benzyl ester;

{1-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-4-yl}-carbamic acid 3-chloro-benzyl ester;

[1-(5,5-Difluoro-hexyl)-1H-pyrazol-3-yl]carbamic acid 2-methyl-benzyl ester;

{1-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-4-yl}-carbamic acid 3,4-dimethyl-benzyl ester;

[1-(5,5-Difluoro-hexyl)-1H-pyrazol-4-yl]-carbamic acid benzyl ester;

[1-(5,5-Difluoro-hexyl)-1H-pyrazol-3-yl]-carbamic acid 2,5-dimethyl-benzyl ester;

[1-(5,5-Difluoro-hexyl)-1H-pyrazol-3-yl]carbamic acid 3-methyl-benzyl ester;

[1-(5,5-Difluoro-hexyl)-1H-pyrazol-4-yl]carbamic acid 2-ethyl-benzyl ester;

[1-(5,5-Difluoro-hexyl)-1H-pyrazol-4-yl]-carbamic acid 2-methyl-benzyl ester;

[1-(5,5-Difluoro-hexyl)-1H-pyrazol-4-yl]carbamic acid 3-methyl-benzyl ester;

[1-(5,5-Difluoro-hexyl)-1H-pyrazol-4-yl]-carbamic acid 2,5-dimethyl-benzyl ester;

{1-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-4-yl}-carbamic acid 2-ethyl-benzyl ester;

{1-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-4-yl}-carbamic acid 3-methyl-benzyl ester;

{1-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-4-yl}-carbamic acid 2,5-dimethyl-benzyl ester;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-3-(2,4-dimethoxy-phenyl)-acrylamide;

5-(3-Fluoro-phenyl)-2-methyl-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-3-(4-chloro-phenyl)-acrylamide;

2-Methyl-5-(3-trifluoromethoxy-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

5-(3,4-Dimethyl-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-3-(2,4-dimethoxy-phenyl)-acrylamide;

5-(3,4-Dimethyl-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

5-(3-Fluoro-phenyl)-2-methyl-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-3-(4-methoxy-phenyl)-acrylamide;

2-Methyl-5-(3-trifluoromethyl-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-3-(4-chloro-phenyl)-acrylamide;

5-(3-Chloro-phenyl)-2-methyl-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

2-Methyl-5-(3-trifluoromethoxy-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

5-Biphenyl-3-yl-2-methyl-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

5-p-Tolyl-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

5-p-Tolyl-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

2-Methyl-5-(3-trifluoromethyl-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-carbamic acid 4-fluoro-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-carbamic acid 3-bromo-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 4-fluoro-benzyl ester;

[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 3-bromo-benzyl ester;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-3-(2,3-difluoro-4-trifluoromethyl-phenyl)-acrylamide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-3-(2,5-difluoro-4-methoxy-phenyl)-acrylamide;

5-(4-Trifluoromethyl-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

5-(3-Trifluoromethyl-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

5-(3-Fluoro-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

5-(4-Chloro-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

5-(4-Fluoro-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

5-(4-Trifluoromethoxy-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

5-(4-Trifluoromethoxy-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

5-(3-Trifluoromethyl-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-3-(4-chloro-3,5-difluoro-phenyl)-acrylamide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-3-(2,5-difluoro-4-trifluoromethyl-phenyl)-acrylamide;

5-(4-Chloro-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

5-(3-Chloro-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

5-(3-Chloro-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

5-(3-Fluoro-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

5-Biphenyl-3-yl-2-methyl-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

5-(3-Chloro-phenyl)-2-methyl-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

5-Biphenyl-3-yl-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

5-Biphenyl-3-yl-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

5-(3-Methoxy-phenyl)-2-methyl-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

5-m-Tolyl-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

2-Methyl-5-phenyl-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

[1-(5-Acetyl-thiophen-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 2-chloro-benzyl ester;

5-Phenyl-oxazole-4-carboxylic acid [1-(3-acetyl-isoxazol-5-ylmethyl)-1H-pyrazol-4-yl]-amide;

[1-(6-Acetyl-pyridin-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 2-chloro-benzyl ester;

5-Phenyl-oxazole-4-carboxylic acid [1-(6-acetyl-pyridin-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

(E)-N-[1-(6-Acetyl-pyridin-2-ylmethyl)-1H-pyrazol-4-yl]-3-(4-trifluoromethyl-phenyl)-acrylamide;

[1-(3-Acetyl-benzyl)-1H-pyrazol-4-yl]carbamic acid 2-chloro-benzyl ester;

5-Phenyl-oxazole-4-carboxylic acid [1-(3-acetyl-benzyl)-1H-pyrazol-4-yl]-amide;

5-Pyridin-2-yl-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

5-Phenyl-oxazole-4-carboxylic acid [1-(5-acetyl-thiophen-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

(E)-N-[1-(5-Acetyl-thiophen-2-ylmethyl)-1H-pyrazol-4-yl]-3-(4-trifluoromethyl-phenyl)-acrylamide;

5-(3-Trifluoromethoxy-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

5-(3-Trifluoromethoxy-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

5-(3-Cyano-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

5-(3-Carbamoyl-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

5-(3-Dimethylamino-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

5-Phenyl-oxazole-4-carboxylic acid [1-(5-acetyl-thiophen-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

(E)-N-[1-(5-Acetyl-thiophen-2-ylmethyl)-1H-pyrazol-3-yl]-3-(4-trifluoromethyl-phenyl)-acrylamide;

[1-(5-Acetyl-thiophen-2-ylmethyl)-1H-pyrazol-3-yl]-carbamic acid 2-chloro-benzyl ester;

5-[3-(2-Methoxy-ethyl)-phenyl]-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

5-(3-Cyano-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

3-{4-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-ylcarbamoyl]-oxazol-5-yl}-benzoic acid tert-butyl ester;

[1-(5-Acetyl-pyridin-3-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 2-chloro-benzyl ester;

5-[3-(2-Hydroxy-ethyl)-phenyl]-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

5-(3-Methoxymethyl-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

[1-(4-Acetyl-pyridin-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 2-chloro-benzyl ester;

{4-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-ylcarbamoyl]-5-phenyl-oxazol-2-ylmethyl}-carbamic acid tert-butyl ester;

[1-(4-Acetyl-thiazol-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 2-chloro-benzyl ester;

5-Phenyl-oxazole-4-carboxylic acid [1-(4-acetyl-thiazol-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

(E)-N-[1-(4-Acetyl-thiazol-2-ylmethyl)-1H-pyrazol-4-yl]-3-(4-trifluoromethyl-phenyl)-acrylamide;

2-Aminomethyl-5-phenyl-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

2-Methyl-5-(3-trifluoromethoxy-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-thiophen-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

2-Methyl-5-(3-trifluoromethoxy-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-thiophen-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

5-m-Tolyl-oxazole-4-carboxylic acid [1-(5-acetyl-thiophen-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

5-m-Tolyl-oxazole-4-carboxylic acid [1-(5-acetyl-thiophen-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

2-Methyl-5-m-tolyl-thiazole-4-carboxylic acid [1-(5-acetyl-thiophen-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

5-(4-Chloro-phenyl)-2-methyl-thiazole-4-carboxylic acid [1-(5-acetyl-thiophen-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

5-(3-Cyano-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-thiophen-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

5-(3-Cyano-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-thiophen-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

5-(3-Dimethylamino-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-thiophen-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

5-(3-Dimethylamino-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-thiophen-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

2-Cyclopropyl-5-phenyl-oxazole-4-carboxylic acid [1-(5-acetyl-thiophen-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

2-Cyclopropyl-5-phenyl-oxazole-4-carboxylic acid [1-(5-acetyl-thiophen-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

5-(3-Methoxy-4-methyl-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-thiophen-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

5-(3-Hydroxymethyl-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

5-[3-(2-Dimethylamino-ethyl)-phenyl]-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

5-(3-Dimethylaminomethyl-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

[1-(2-Acetyl-pyridin-4-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 2-chloro-benzyl ester;

5-Phenyl-oxazole-4-carboxylic acid [1-(5-acetyl-thiophen-3-ylmethyl)-1H-pyrazol-4-yl]-amide;

[1-(2-Acetyl-thiazol-4-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 2-chloro-benzyl ester;

(E)-N-[1-(6-Acetyl-pyridin-2-ylmethyl)-1H-pyrazol-3-yl]-3-(4-trifluoromethyl-phenyl)-acrylamide;

[1-(6-Acetyl-pyridin-2-ylmethyl)-1H-pyrazol-3-yl]-carbamic acid 2-chloro-benzyl ester;

5-(2-Fluoro-pyridin-4-yl)-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

5-Phenyl-oxazole-4-carboxylic acid [1-(5-methanesulfonyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

5-Pyridin-4-yl-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

5-(6-Methyl-pyridin-2-yl)-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

2-Methoxymethyl-5-phenyl-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

2-Methoxymethyl-5-phenyl-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

{4-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-ylcarbamoyl]-5-phenyl-oxazol-2-ylmethyl}-carbamic acid tert-butyl ester;

5-(6-Trifluoromethyl-pyridin-2-yl)-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

5-Isoxazol-5-yl-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

5-Phenyl-oxazole-4-carboxylic acid [1-(2-acetyl-thiazol-4-ylmethyl)-1H-pyrazol-3-yl]-amide;

2-(2-Methoxy-ethyl)-5-phenyl-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

2-(2-Methoxy-ethyl)-5-phenyl-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

2-Isopropyl-5-phenyl-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

2-Butyl-5-phenyl-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

2-Isopropyl-5-phenyl-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

2-Butyl-5-phenyl-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

5-(3-Isopropoxymethyl-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

5-[3-(2-Isopropoxy-ethyl)-phenyl]-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

[1-(4-Acetyl-thiazol-2-ylmethyl)-1H-pyrazol-3-yl]-carbamic acid 2-chloro-benzyl ester;

5-Phenyl-oxazole-4-carboxylic acid [1-(4-acetyl-thiazol-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

2-Benzyl-5-phenyl-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

2-Benzyl-5-phenyl-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

3-{4-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-ylcarbamoyl]-5-phenyl-oxazol-2-yl}-propionic acid tert-butyl ester;

5-Phenyl-oxazole-4-carboxylic acid [1-(5-acetyl-thiazol-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

[1-(5-Acetyl-thiazol-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 2-chloro-benzyl ester;

5-Phenyl-oxazole-4-carboxylic acid [1-(2-acetyl-thiazol-5-ylmethyl)-1H-pyrazol-4-yl]-amide;

(E)-N-[1-(2-Acetyl-thiazol-5-ylmethyl)-1H-pyrazol-4-yl]-3-(4-trifluoromethyl-phenyl)-acrylamide;

[1-(2-Acetyl-thiazol-5-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 2-chloro-benzyl ester;

5-Phenyl-oxazole-4-carboxylic acid [1-(2-acetyl-oxazol-5-ylmethyl)-1H-pyrazol-3-yl]-amide;

5-Phenyl-oxazole-4-carboxylic acid [1-(4-acetyl-thiophen-2-ylmethyl)-1H-pyrazol-4-yl]-amide;

[1-(4-Acetyl-thiophen-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 2-chloro-benzyl ester;

2-Methyl-5-m-tolyl-oxazole-4-carboxylic acid [1-(4-acetyl-thiazol-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

5-(3-Chloro-phenyl)-2-methyl-oxazole-4-carboxylic acid [1-(4-acetyl-thiazol-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

5-m-Tolyl-oxazole-4-carboxylic acid [1-(4-acetyl-thiazol-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

2-Methyl-5-phenyl-oxazole-4-carboxylic acid [1-(4-acetyl-thiazol-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

2-Methyl-5-(3-trifluoromethyl-phenyl)-oxazole-4-carboxylic acid [1-(4-acetyl-thiazol-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

5-(3-Fluoro-phenyl)-oxazole-4-carboxylic acid [1-(4-acetyl-thiazol-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

5-(3-Dimethylamino-phenyl)-oxazole-4-carboxylic acid [1-(4-acetyl-thiazol-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

5-(3-Chloro-phenyl)-oxazole-4-carboxylic acid [1-(4-acetyl-thiazol-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

2-Methyl-5-(3-trifluoromethoxy-phenyl)-oxazole-4-carboxylic acid [1-(4-acetyl-thiazol-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

5-(3-Trifluoromethoxy-phenyl)-oxazole-4-carboxylic acid [1-(4-acetyl-thiazol-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

5-(3-Methoxy-phenyl)-oxazole-4-carboxylic acid [1-(4-acetyl-thiazol-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

(E)-N-[1-(4-Acetyl-thiazol-2-ylmethyl)-1H-pyrazol-3-yl]-3-(4-trifluoromethyl-phenyl)-acrylamide;

(E)-N-[1-(4-Acetyl-thiazol-2-ylmethyl)-1H-pyrazol-3-yl]-3-(2-trifluoromethyl-phenyl)-acrylamide;

(E)-N-[1-(4-Acetyl-thiazol-2-ylmethyl)-1H-pyrazol-3-yl]-3-(3-trifluoromethoxy-phenyl)-acrylamide;

(E)-N-[1-(4-Acetyl-thiazol-2-ylmethyl)-1H-pyrazol-3-yl]-3-(2-chloro-4-fluoro-phenyl)-acrylamide;

5-(3-Methoxy-phenyl)-2-methyl-oxazole-4-carboxylic acid [1-(4-acetyl-thiazol-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

5-(3-Fluoro-phenyl)-2-methyl-oxazole-4-carboxylic acid [1-(4-acetyl-thiazol-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

5-Phenyl-oxazole-4-carboxylic acid [1-(4-acetyl-oxazol-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

5-Phenyl-oxazole-4-carboxylic acid {1-[4-(1,1-difluoro-ethyl)-thiazol-2-ylmethyl]-1H-pyrazol-3-yl}-amide;

[1-(5-Oxo-hexyl)-1H-pyrazol-4-yl]carbamic acid benzothiazol-2-ylmethyl ester;

5-(6-Trifluoromethyl-pyridin-2-yl)-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-amide;

(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-3-(1H-indol-3-yl)-acrylamide;

5-Phenyl-oxazole-4-carboxylic acid [1-(5-acetyl-oxazol-2-ylmethyl)-1H-pyrazol-3-yl]-amide; or

[1-(2-Acetyl-oxazol-4-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 2-chloro-benzyl ester;

or a salt thereof.

11. A medicinal compound of comprising the formula according to claim 1 , or a pharmaceutically acceptable salt thereof.

12. A pharmaceutical composition comprising as an active principle the compound of claim 1 or a pharmaceutically acceptable salt thereof, and at least one therapeutically inert excipient.

13. A method of treating a disease comprising the administration of a therapeutically effective amount of the compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein the disease is selected from acute lung injury, adult/acute respiratory distress syndrome, asthma, hyper-neutrophilia, periodontitis, glomerulonephritis, cystic fibrosis, psoriasis, contact dermatitis, atopic dermatitis, dermatitis herpetiformis, scleroderma, hypersensitivity angiitis, urticaria, lupus erythematosus, epidermolysis, conjunctivitis, keratoconjunctivitis sicca, vernal conjunctivitis, inflammatory disease in which autoimmune reactions are implicated or which have an autoimmune component or aetiology, autoimmune inflammatory bowel disease, HIV-mediated retroviral infections, neuroinflammation, stroke, cerebral ischemia, Alzheimer's disease, Parkinson's disease, transmissible spongiform encephalopathies, mild cognitive impairment, dementia with Lewy bodies, Down's syndrome, cerebral hemorrhage with amyloidosis, progressive supranuclear palsy, multiple sclerosis, Creutzfeld Jakob disease, HIV-related dementia, amyotropic lateral sclerosis, inclusion-body myositis, adult onset diabetes or senile cardiac amyloidosis.

14. A method of treating a disease comprising the administration of a therapeutically effective amount of the composition of claim 12 or a pharmaceutically acceptable salt thereof, wherein the disease is selected from acute lung injury, adult/acute respiratory distress syndrome, asthma, hyper-neutrophilia, periodontitis, glomerulonephritis, cystic fibrosis, psoriasis, contact dermatitis, atopic dermatitis, dermatitis herpetiformis, scleroderma, hypersensitivity angiitis, urticaria, lupus erythematosus, epidermolysis, conjunctivitis, keratoconjunctivitis sicca, vernal conjunctivitis, inflammatory disease in which autoimmune reactions are implicated or which have an autoimmune component or aetiology, autoimmune inflammatory bowel disease, HIV-mediated retroviral infections, neuroinflammation, stroke, cerebral ischemia, Alzheimer's disease, Parkinson's disease, transmissible spongiform encephalopathies, mild cognitive impairment, dementia with Lewy bodies, Down's syndrome, cerebral hemorrhage with amyloidosis, progressive supranuclear palsy, multiple sclerosis, Creutzfeld Jakob disease, HIV-related dementia, amyotropic lateral sclerosis, inclusion-body myositis, adult onset diabetes or senile cardiac amyloidosis.

15. The compound of claim 6 , wherein R 3 represents hydrogen or methyl; or a salt thereof.

16. The compound of claim 15 , wherein R 1 represents phenyl, which is unsubstituted, mono-, di- or tri-substituted with halogen, (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )fluoroalkyl, (C 1 -C 4 )fluoroalkoxy, phenyl, cyano, dimethylamino, —C(O)OtBu or (C 1 -C 4 )alkoxy-(C 1 -C 2 )alkyl;

or a salt thereof.

17. The compound of claim 16 , wherein R 2 represents —CO—(C 1 -C 3 )alkyl or —CF 2 —(C 1 -C 3 )alkyl; or a salt thereof.