Anti-dandruff compositions containing peptides
The present invention relates to the use of special peptides in composition which can be used in particular in hair and skin cosmetics, and to such peptide-containing compositions. In particular, the present invention relates to the use of such peptides as active ingredient for inhibition or treatment of dandruff which does not accumulate in the body or in the environment. Furthermore, the invention relates to the production of such compositions, to the peptides used themselves, to their production and to coding nucleotide sequences for such peptides, to dispensing systems for such peptides and to screening methods for identifying suitable further peptides.
1. A method for treatment of dandruff, comprising topical application to a person in need of treatment of dandruff of a composition comprising a cosmetic carrier and a Malassezia furfur -inhibiting amount of at least one peptide with a sequence or a repetitive sequence motif according to SEQ ID NO: 2:
(SEQ ID NO: 2)
X 1 X 2 K X 3 X 4 X 5 KIP X 11 X 12 KFX 6 X 7 X 8 AX 9 KF
in which
X 1 is lysine, arginine or phenylalanine,
X 2 is lysine or tryptophan,
X 3 is leucine or lysine,
X 4 is phenylalanine or leucine,
X 5 is leucine or lysine,
X 6 is leucine or lysine,
X 7 is histidine or lysine,
X 8 is alanine, leucine, valine or serine,
X 9 is leucine or lysine,
X 11 is proline or a chemical bond, and
X 12 is proline or a chemical bond,
where the repetitive sequence motifs are identical or different; or peptide derivatives thereof selected from the group consisting of aliphatic esters, amides, N-acyl peptides, O-acyl peptides, and peptides wherein between 1 to 5 arbitrary amino acid residues are N- and/or C-terminally added or deleted.
2. The method of claim 1 , wherein the composition comprises a peptide with a sequence or a repetitive sequence motif according to SEQ ID NO: 3
KWKLFKKIPKFLHLAKKF
(SEQ ID NO: 3)
or peptide derivatives thereof selected from the group consisting of aliphatic esters, amides, N-acyl peptides, O-acyl peptides, and peptides wherein between 1 to 5 arbitrary amino acid residues are N- and/or C-terminally added or deleted.
3. The method of claim 2 , wherein the composition comprises a peptide with a repetitive sequence motif, where a plurality of peptides according to SEQ ID NO: 3 or said peptide derivatives thereof are peptidically linked together via linker groups.
4. The method of claim 1 , wherein the composition comprises a peptide with a repetitive sequence motif, where a plurality of peptides according to SEQ ID NO: 2 or said peptide derivatives thereof are peptidically linked together via linker groups.
5. The method according to of claim 4 , where the linkers comprise 1 to 10 continuous identical or different amino acid residues selected from alanine, glycine, threonine and serine.
6. The method of claim 1 , where the C-terminal carboxyl group of the peptide is amidated.
7. The method of claim 1 , wherein the composition inhibits Malassezia furfur under standard conditions at a minimum inhibitory concentration of about 0.1 μM-1500 μM.
8. The method of claim 1 , wherein the composition additionally comprises at least one further cosmetic or pharmaceutical active ingredient.
9. The method of claim 1 , wherein the composition additionally comprises at least one anti-inflammatory active ingredient.
10. The method of claim 1 , wherein the composition additionally comprises an antimicrobial active ingredient for inhibiting the growth and/or the activity of undesired germs.
11. The method of claim 1 , wherein the composition additionally comprises a sebum-regulating active ingredient.
12. The method of claim 1 , where the peptide is present in the composition in a fraction of from 0.0001 to 50% by weight, based on the total weight of the finished composition.