Aminotriazole derivatives as ALX agonists

1. A compound of formula (I),

wherein

A represents a phenyl- or a heterocyclyl-group, wherein the phenyl- or heterocyclyl-group is substituted in a 1,3-arrangement; or A represents propan-1,3-diyl;

E represents *—(C 1 -C 4 )alkyl-O—, —CH═CH— or

wherein the asterisks indicate the bond which is linked to R 1 ;

Q represents O or S;

R 3 represents hydrogen, (C 1 -C 4 )alkyl, cyclopropyl, (C 1 -C 4 )alkoxy-(C 1 -C 2 )alkyl, benzyl or —CH 2 CH 2 C(O)OtBu;

R 1 represents a pyridyl- or an aryl-group, which group is unsubstituted, mono-, di- or tri-substituted with

halogen, (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )fluoroalkyl, (C 1 -C 4 ) fluoroalkoxy, di-[(C 1 -C 3 )alkyl]-amino or (C 1 -C 4 )alkoxy-(C 1 -C 2 )alkyl; and

R 2 represents —CO—(C 1 -C 3 )alkyl, —CF 2 —(C 1 -C 3 )alkyl, or —SO 2 —(C 1 -C 3 )alkyl;

or a salt thereof.

2. The compound of formula (I) according to claim 1 , wherein A represents phenyl-1,3-diyl, furan-2,5-diyl, oxazol-2,4-diyl, oxazol-2,5-diyl, thiophen-2,4-diyl, thiophen-2,5-diyl, thiazol-2,4-diyl, thiazol-2,5-diyl, pyridin-2,4-diyl, pyridin-2,6-diyl or propan-1,3-diyl; or a salt thereof.

3. The compound of formula (I) according to claim 1 , wherein A represents furan-2,5-diyl, oxazol-2,4-diyl with R 2 being attached in 2-position, oxazol-2,4-diyl with R 2 being attached in 4-position, oxazol-2,5-diyl with R 2 being attached in 2-position, thiophen-2,5-diyl or thiazol-2,4-diyl with R 2 being attached in 4-position; or a salt thereof.

4. The compound of formula (I) according to claim 1 , wherein A represents furan-2,5-diyl or thiophen-2,5-diyl; or a salt thereof.

5. The compound of formula (I) according to claim 1 , wherein A represents propan-1,3-diyl; or a salt thereof.

6. The compound of formula (I) according to claim 1 , wherein E represents *—(C 1 -C 4 )alkyl-O— or —CH═CH—; or a salt thereof.

7. The compound of formula (I) according to claim 1 , wherein E represents

or a salt thereof.

8. The compound of formula (I) according to claim 1 , wherein R 3 represents hydrogen or methyl;

or a salt thereof.

9. The compound of formula (I) according to claim 1 , wherein

R 1 represents phenyl, which is unsubstituted, mono- or di-substituted

with halogen, (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy, trifluoromethyl, trifluoromethoxy, or dimethylamino;

or a salt thereof.

10. The compound of formula (I) according to claim 1 , wherein R 2 represents —CO—(C 1 -C 3 )alkyl; or a salt thereof.

11. The compound of formula (I) according to claim 1 , wherein the compound is:

5-Phenyl-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-amide;

(E)-N-[2-(5-Acetyl-furan-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-3-(4-trifluoromethyl -phenyl)-acrylamide;

5-(3-Methoxy-phenyl)-2-methyl-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-2H -[1,2,3]triazol-4-yl]-amide; or

[2-(5-Acetyl-furan-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-carbamic acid 2-chloro-benzyl ester; or a salt thereof.

12. The compound of formula (I) according to claim 1 , wherein the compound is:

5-Phenyl-oxazole-4-carboxylic acid [2-(5-oxo-hexyl)-2H-[1,2,3]triazol-4-yl]-amide;

(E)-N-[2-(5-Acetyl-furan-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-3-(4-chloro-phenyl)-acrylamide;

(E)-N-[2-(5-Acetyl-furan-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-3-(4-trifluoromethyl-phenyl)-acrylamide;

(E)-N-[2-(5-Acetyl-furan-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-3-(3-trifluoromethoxy-phenyl)-acrylamide;

(E)-N-[2-(5-Acetyl-furan-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-3-o-tolyl-acrylamide;

(E)-N-[2-(5-Acetyl-furan-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-3-(2-chloro-4-fluoro-phenyl)-acrylamide;

(E)-N-[2-(5-Acetyl-furan-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-3-m-tolyl-acrylamide;

(E)-N-[2-(5-Acetyl-furan-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-3-p-tolyl-acrylamide;

(E)-N-[2-(5-Acetyl-furan-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-3-(4-methoxy-phenyl)-acrylamide;

5-(3,5-Dimethyl-phenyl)-2-methyl-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-amide;

5-(3-Trifluoromethyl-phenyl)-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl) -2H-[1,2,3]triazol-4-yl]-amide;

5-(3-Fluoro-phenyl)-2-methyl-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl) -2H-[1,2,3]triazol-4-yl]-amide;

5-(4-Chloro-phenyl)-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-2H -[1,2,3]triazol-4-yl]-amide;

2-Methyl-5-m-tolyl-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-2H -[1,2,3]triazol-4yl]-amide;

5-(3-Trifluoromethoxy-phenyl)-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-amide;

5-(3-Chloro-phenyl)-2-methyl-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl) -2H-1,2,3]triazol-4-yl]-amide;

5-(3-Methoxy-4-methyl-phenyl)-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-amide;

5-(4-Fluoro-phenyl)-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-2H -[1,2,3]triazol-4-yl]-amide;

5-m-Tolyl-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-2H-1,2,3]triazol-4-yl]-amide;

5-(3-Methoxy-phenyl)-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-2H -[1,2,3]triazol-4-yl]-amide;

2-Methyl-5-phenyl-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-2H -[1,2,3]triazol-4-yl]-amide;

2-Methyl-5-(3-trifluoromethyl-phenyl)-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-amide;

2-Methyl-5-(3-trifluoromethoxy-phenyl)-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-amide;

2-Methyl-5-o-tolyl-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-2H -[1,2,3]triazol-4-yl]-amide;

2-Ethyl-5-phenyl-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-2H -[1,2,3]triazol-4-yl]-amide;

2-Cyclopropyl-5-phenyl-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-2H -[1,2,3]triazol-4-yl]-amide;

5-(3-Fluoro-phenyl)-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-2H -[1,2,3]triazol-4-yl]-amide;

5-(3-Chloro-phenyl)-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-2H -[1,2,3]triazol-4-yl]-amide;

5-Phenyl-oxazole-4-carboxylic acid [2-(5-acetyl-thiophen-2-ylmethyl)-2H-[1,2,3]triazol -4-yl]-amide;

5-Phenyl-oxazole-4-carboxylic acid [2-(3-acetyl-benzyl)-2H-[1,2,3]triazol-4-yl]-amide;

[2-(3-Acetyl-benzyl)-2H-[1,2,3]triazol-4-yl]-carbamic acid 2-chloro-benzyl ester;

5-Phenyl-oxazole-4-carboxylic acid [2-(5,5-difluoro-hexyl)-2H-[1,2,3]triazol-4-yl]-amide;

5-Phenyl-oxazole-4-carboxylic acid [2-(5-methanesulfonyl-furan-2-ylmethyl)-2H -[1,2,3]triazol-4-yl]-amide;

5-(3-Dimethylamino-phenyl)-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl) -2H-[1,2,3]triazol-4-yl]-amide;

5-Phenyl-oxazole-4-carboxylic acid [2-(4-acetyl-thiazol-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-amide;

[2-(4-Acetyl-thiazol-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-carbamic acid 2-chloro-benzyl ester;

[2-(4-Acetyl-pyridin-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-carbamic acid 2-chloro-benzyl ester;

5-[3-(2-Methoxy-ethyl)-phenyl]-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-amide ;

5-Phenyl-oxazole-4-carboxylic acid [2-(6-acetyl-pyridin-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-amide;

5-(3-Methoxymethyl-phenyl)-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl) -2H-[1,2,3]triazol-4-yl]-amide;

5-Phenyl-oxazole-4-carboxylic acid [2-(2-acetyl-thiazol-4-ylmethyl)-2H-[1,2,3]triazol-4-yl]-amide;

5-Phenyl-oxazole-4-carboxylic acid [2-(4-acetyl-pyridin-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-amide;

5-Phenyl-oxazole-4-carboxylic acid [2-(2-acetyl-pyridin-4-ylmethyl)-2H-[1,2,3]triazol-4-yl]-amide;

[2-(2-Acetyl-pyridin-4-ylmethyl)-2H-[1,2,3]triazol-4-yl]-carbamic acid 2-chloro-benzyl ester;

5-Phenyl-oxazole-4-carboxylic acid [2-(5-acetyl-thiophen-3-ylmethyl)-2H-[1,2,3]triazol-4-yl]-amide; or 2-Methyl-5-m-tolyl-thiazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-2H -[1,2,3]triazol-4-yl]-amide;

or a salt thereof.

13. The compound of formula (I) according to claim 1 , wherein the compound is:

5-Phenyl-oxazole-4-carboxylic acid [2-(3-acetyl-isoxazol-5-ylmethyl)-2H-[1,2,3]triazol-4-yl]-amide;

5-(3-Isopropoxymethyl-phenyl)-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-2H-[1 ,2,3]triazol-4-yl]-amide;

5-[3-(2-Isopropoxy-ethyp-phenyl]-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-amide;

2-Methyl-5-m-tolyl-oxazole-4-carboxylic acid [2-(5-acetyl-thiophen-2-ylmethyl)-2H-[1,2,3]triazol-4-yl1-amide;

5-(3-Chloro-phenyl)-2-methyl-oxazole-4-carboxylic acid [2-(5-acetyl-thiophen-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-amide;

5-m-Tolyl-oxazole-4-carboxylic acid [2-(5-acetyl-thiophen-2-ylmethyl)-2H -[1,2,3]triazol-4-yl]-amide;

2-Methyl-5-phenyl-oxazole-4-carboxylic acid [2-(5-acetyl-thiophen-2-ylmethyl)-2H -[1,2,3]triazol-4-yl]-amide;

2-Methyl-5-(3-trifluoromethyl-phenyl)-oxazole-4-carboxylic acid [2-(5-acetyl-thiophen -2-ylmethyl)-2H1 ,2,3]triazol-4-yl]-amide ;

5-(3-Fluoro-phenyl)-oxazole-4-carboxylic acid [2-(5-acetyl-thiophen-2-ylmethyl)-2H -[1,2,3]triazol-4-yl]-amide;

5-(3-Dimethylamino-phenyl)-oxazole-4-carboxylic acid [2-(5-acetyl-thiophen-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-amide;

5-(3-Chloro-phenyl)-oxazole-4-carboxylic acid [2-(5-acetyl-thiophen-2-ylmethyl)-2H -[1,2,3]triazol-4-yl]-amide;

2-Methyl-5-(3-trifluoromethoxy-phenyl)-oxazole-4-carboxylic acid [2-(5-acetyl -thiophen-2-ylmethyl)-2H-[1,2,3triazol-4-yl]-amide;

5-(4-Fluoro-phenyl)-oxazole-4-carboxylic acid [2-(5-acetyl-thiophen-2-ylmethyl)-2H -[1,2,3]triazol-4-yl]-amide;

5-(3-Trifluoromethoxy-phenyl)-oxazole-4-carboxylic acid [2-(5-acetyl-thiophen-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-amide;

5-(3-Methoxy-phenyl)-oxazole-4-carboxylic acid [2-(5-acetyl-thiophen-2-ylmethyl)-2H -[1,2,3]triazol-4-yl]-amide;

5-(3-Fluoro-phenyl)-thiazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-2H -[1,2,3]triazol-4-yl]-amide;

5-Phenyl-oxazole-4-carboxylic acid [2-(2-acetyl-thiazol-5-ylmethyl)-2H-[1,2,3]triazol-4-yl]-amide;

[2-(2-Acetyl-thiazol-5-ylmethyl)-2H-[1,2,3]triazol-4-yl]-carbamic acid 2-chloro-benzyl ester;

(E)-N-[2-(2-Acetyl-thiazol-5-ylmethyl)-2H-[1,2,3]triazol-4-yl]-3-(4-trifluoromethyl -phenyl)-acrylamide;

5-Phenyl-oxazole-4-carboxylic acid [2-(2-acetyl-oxazol-5-ylmethyl)-2H-[1,2,3]triazol-4-yl]-amide;

[2-(5-Acetyl-thiazol-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-carbamic acid 2-chloro-benzyl ester;

5-Phenyl-oxazole-4-carboxylic acid [2-(4-acetyl-thiophen-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-amide;

5-Phenyl-oxazole-4-carboxylic acid [2-(5-acetyl-thiazol-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-amide;

(E)-N-[2-(5-Acetyl-thiazol-2-ylmethyl)-2H11,2,3]triazol-4-yl]-3-(4-trifluoromethyl -phenyl)-acrylamide;

2-Methyl-5-m-tolyl-oxazole-4-carboxylic acid [2-(4-acetyl-thiazol-2-ylmethyl)-2H -[1,2,3]triazol-4-yl]-amide;

5-(3-Chloro-phenyl)-2-methyl-oxazole-4-carboxylic acid [2-(4-acetyl-thiazol-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-amide;

2-Methyl-5-phenyl-oxazole-4-carboxylic acid [2-(4-acetyl-thiazol-2-ylmethyl)-2H -[1,2,3]triazol-4-yl]-amide;

2-Methyl-5-(3-trifluoromethyl-phenyl)-oxazole-4-carboxylic acid [2-(4-acetyl-thiazol-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-amide;

5-(3-Fluoro-phenyl)-oxazole-4-carboxylic acid [2-(4-acetyl-thiazol-2-ylmethyl)-2H -[1,2,3]triazol-4-yl]-amide;

5-(3-Dimethylamino-phenyl)-oxazole-4-carboxylic acid [2-(4-acetyl-thiazol-2-ylmethyl)-2H-[1,2,3]triazol-4-yl1-amide;

5-(3-Chloro-phenyl)-oxazole-4-carboxylic acid [2-(4-acetyl-thiazol-2-ylmethyl)-2H -[1,2,3]triazol-4-yl]-amide;

2-Methyl-5-(3-trifluoromethoxy-phenyl)-oxazole-4-carboxylic acid [2-(4-acetyl-thiazol-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-amide;

5-(4-Fluoro-phenyl)-oxazole-4-carboxylic acid [2-(4-acetyl-thiazol-2-ylmethyl)-2H -[1,2,3]triazol-4-yl]-amide;

5-(3-Trifluoromethoxy-phenyl)-oxazole-4-carboxylic acid [2-(4-acetyl-thiazol-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-amide;

5-(3-Methoxy-phenyl)-oxazole-4-carboxylic acid [2-(4-acetyl-thiazol-2-ylmethyl)-2H -[1,2,3]triazol-4-yl]-amide;

(E)-N42-(4-Acetyl-thiazol-2-ylmethyl)-2H-[1,2,3]triazol-4-yl1-3-(4-trifluoromethyl-phenyl)-acrylamide;

(E)-N-[2-(4-Acetyl-thiazol-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-3-(3-trifluoromethoxy-phenyl)-acrylamide;

5-(3-Methoxy-phenyl)-2-methyl-oxazole-4-carboxylic acid [2-(4-acetyl-thiazol-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-amide;

5-(3-Fluoro-phenyl)-2-methyl-oxazole-4-carboxylic acid [2-(4-acetyl-thiazol-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-amide;

2-Methyl-5-m-tolyl-thiazole-4-carboxylic acid [2-(4-acetyl-thiazol-2-ylmethyl)-2H -[1,2,3]triazol-4-yl]-amide;

5-Phenyl-oxazole-4-carboxylic acid [2-(4-acetyl-oxazol-2-ylmethyl)-2H-[1,2,3triazol-4-yl]-amide;

2-Methoxymethyl-5-phenyl-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-amide;

2-(2-Methoxy-ethyl)-5-phenyl-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-amide;

2-Butyl-5-phenyl-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-2H -[1,2,3]triazol-4-yll-amide;

2-Isopropyl-5-phenyl-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-2H -[1,2,3]triazol-4-yl]-amide;

(E)-N42-(4-Acetyl-thiazol-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-3-(2-trifluoromethyl-phenyl)-acrylamide;

2-Benzyl-5-phenyl-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-2H -[1,2,3]triazol-4-yl1-amide;

3- I 4- [2-(5-Acetyl-furan-2-ylmethyl)-2H- [1,2,3]triazol-4-ylcarbamoyl]-5-phenyl-oxazol-2-yl ]-propionic acid tert-butyl ester;

5-(3-Fluoro-phenyl)-2-methyl-oxazole-4-carboxylic acid [2-(2-acetyl-oxazol-5-ylmethyl)-2H-[1,2,3triazol-4-yl]-amide;

2-Methyl-5-m-tolyl-oxazole-4-carboxylic acid [2-(2-acetyl-oxazol-5-ylmethyl)-2H -[1,2,3]triazol-4-ylFamide;

5-(3-Chloro-phenyl)-2-methyl-oxazole-4-carboxylic acid [2-(2-acetyl-oxazol-5-ylmethyl)-2H-[1,2,3]triazol-4-yl]-amide;

5-m-Tolyl-oxazole-4-carboxylic acid [2-(2-acetyl-oxazol-5-ylmethyl)-2H-[1,2,3]triazol-4-yl]-amide;

2-Methyl-5-(3-trifluoromethoxy-phenyl)-oxazole-4-carboxylic acid [2-(2-acetyl-oxazol-5-ylmethyl)-2H-[1,2,3]triazol-4-yl]-amide;

[2-(2-Acetyl-oxazol-4-ylmethyl)-2H-[1,2,3]triazol-4- 3 4]-carbamic acid 2-chloro-benzyl ester; or

5-(6-Trifluoromethyl-pyridin-2-yl)-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-2H1,2,3 ] triazol-4-yl]kamide ;

or a salt thereof.

14. A pharmaceutical composition comprising as an active principle the compound of formula (I) according to claim 1 or a pharmaceutically acceptable salt thereof, and at least one therapeutically inert excipient.

15. A method of modulating an immune response comprising the administration of an effective amount of the compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein said effective amount modulates an inflammatory disease or allergic condition and wherein said response is mediated by a lipoxin A4 receptor pathway.

16. A method of modulating an immune response comprising the administration of an effective amount of the composition of claim 14 , wherein the effective amount modulates an inflammatory disease or an allergic condition and wherein said response mediated by a lipoxin A4 receptor pathway.

17. A method for the modulation of an immune response comprising the administration of an effective amount of the compound of formula (I) according to claim 1 , or a pharmaceutically acceptable salt thereof, wherein said response is mediated by a lipoxin A4 receptor pathway.

18. The compound of formula (I) according to claim 3 , wherein E represents

or a salt thereof.

19. The compound of formula (I) according to claim 18 , wherein R 3 represents hydrogen or methyl;

or a salt thereof.

20. The compound of formula (I) according to claim 19 , wherein

R 1 represents phenyl, which is unsubstituted, mono- or di-substituted

with halogen, (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy, trifluoromethyl, trifluoromethoxy, or dimethylamino;

or a salt thereof.

21. A method of treating a disease comprising the administration of a therapeutically effective amount of the compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein the disease is Alzheimer's disease.

22. A method of treating a disease comprising the administration of a therapeutically effective amount of the composition of claim 14 , wherein the disease is Alzheimer's disease.