Process for the preparation of iosimenol
View Patent ↗A process for the preparation of iosimenol comprising reacting 5,5′-[(1,3-dioxo-1,3-propanediyl)diimino]bis[N-(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide] (C-VI) with a 3-halo-1,2-propanediol in an aqueous solvent. A process for the preparation of C-VI comprising reacting 3,3′-[(1,3-dioxo-1,3-propanediyl)diimino]bis[5-(aminocarbonyl)-2,4,6-triiodobenzoyl chloride] (C-V) with 3-amino-1,2-propanediol in the presence of an inorganic base and a suitable non-aqueous polar solvent. A process for the preparation of C-V comprising reacting 3-amino-5-(aminocarbonyl)-2,4,6-triiodobenzoyl chloride (C-IV) with malonyl dichloride in a solvent comprising a suitable ester solvent, a suitable nitrile solvent or mixtures thereof.
1. A process for the preparation of iosimenol, the process comprising reacting 5,5′-[(1,3-dioxo-1,3-propanediyl)diimino]bis[N-(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide], C-VI, with a 3-halo-1,2-propanediol in an aqueous solvent, in the presence of suitable base and a suitable additive, wherein C-VI has the formula:
2. The process of claim 1 wherein the 3-halo-1,2-propanediol is 3-chloro-1,2-propanediol.
3. The process of claim 1 wherein the additive is selected from an alkali metal or alkaline earth metal salt of a halide or C 1 -C 6 carboxylic acid, or combinations thereof; wherein halide is selected from chloride, bromide or iodide.
4. The process of claim 3 wherein the additive is selected from lithium chloride, sodium chloride, potassium chloride, cesium chloride, magnesium chloride, calcium chloride, strontium chloride, barium chloride, or the equivalent bromide, iodide or acetate, or combinations thereof.
5. The process of claim 4 wherein the additive is calcium chloride.
6. The process of claim 1 wherein the aqueous solvent is water.
7. The process of claim 6 wherein the base is sodium hydroxide.
8. The process of claim 1 wherein the process further comprises the preparation of 5,5′-[(1,3-dioxo-1,3-propanediyl)diimino]bis[N-(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide], (C-VI), by reacting 3,3′-[(1,3-dioxo-1,3-propanediyl)diimino]bis[5-(aminocarbonyl)-2,4,6-triiodobenzoyl chloride] (C-V) with 3-amino-1,2-propanediol in the presence of a base wherein C-V has the formula:
9. The process of claim 8 wherein the reaction is carried out in a non-aqueous polar solvent selected from dimethylsulfoxide or amide solvents.
10. The process of claim 8 wherein the base is lithium hydroxide, sodium hydroxide, potassium hydroxide, sodium carbonate, potassium carbonate, lithium carbonate, triethylamine or diisopropylethylamine, tetramethylammonium hydroxide, tetraethylammonium hydroxide, or a combination thereof.
11. The process of claim 9 wherein the solvent is N,N-dimethylacetamide and the base is sodium hydroxide.
12. The process of claim 8 wherein the process further comprises the preparation of C-V by treating 3-amino-5-(aminocarbonyl)-2,4,6-triiodobenzoyl chloride (C-IV) with malonyl dichloride.
13. The process of claim 12 wherein the process further comprises the preparation of 3-amino-5-(aminocarbonyl)-2,4,6-triiodobenzoyl chloride (C-IV) by treating 3-amino-5-(aminocarbonyl)-2,4,6-triiodobenzoic acid (C-III) with a chlorinating reagent in the presence of a catalyst wherein C-III has the formula:
14. The process of claim 13 wherein the chlorinating reagent is thionyl chloride.
15. The process of claim 13 wherein the catalyst is an amide or amine catalyst.
16. The process of claim 15 wherein the catalyst is tetramethylurea, N,N-dimethylformamide, N,N-dimethylacetamide, N-methylmorpholine, N-methylpyrrolidone, 4-dimethylaminopyridine, or a combination thereof.
17. A process for the preparation of 5,5′-[(1,3-dioxo-1,3-propanediyl)diimino]bis[N-(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide], (C-VI), by reacting 3,3′-[(1,3-dioxo-1,3-propanediyl)diimino]bis[5-(aminocarbonyl)-2,4,6-triiodobenzoyl chloride] (C-V) with 3-amino-1,2-propanediol in the presence of an inorganic base selected from alkali metal hydroxides, alkali metal carbonates, or combinations thereof and a suitable non-aqueous polar solvent wherein 3,3′-[(1,3-dioxo-1,3-propanediyl)diimino]bis[5-(aminocarbonyl)-2,4,6-triiodobenzoyl chloride] (C-V) has the formula:
18. The process of claim 17 wherein the solvent comprises a non-aqueous polar solvent selected from dimethylsulfoxide or amide solvents.
19. The process of claim 17 wherein the base is lithium hydroxide, sodium hydroxide, potassium hydroxide, sodium carbonate, potassium carbonate, lithium carbonate, or a combination thereof.
20. The process of claim 18 wherein the solvent is N,N-dimethylacetamide and the base is sodium hydroxide.
21. The process of claim 17 further comprising:
concentrating the C-VI reaction mixture to remove a portion of the non-aqueous polar solvent, and
contacting the concentrated reaction mixture with a non-solubilizing solvent selected from water, 10% to 15% NaCl solution, acetone, alcohols, or combinations thereof.