Methods for treating hepatitis C

1. A compound of formula I

or a pharmaceutically acceptable salt thereof, wherein:

X is: -5-membered heteroaryl optionally substituted with: (1) —C 1 to C 6 alkyl, (2) -cyclopropyl, (3) -cyclobutyl, (4) -cyclopentyl, (5) -cyclohexyl, (6) -aryl optionally substituted with an alkoxy or one or more halogen(s), (7) -5 to 6 membered heteroaryl, or (8) one or more halogen(s);

Y is: -aryl substituted with one or more of the following:

(1) -alkoxy optionally substituted with: (i) -alkoxy, (ii) -hydroxy, (iii) -one or more halogen(s), (iv) -5 or 6 membered heterocycle, optionally substituted with: —C 1 to C 6 alkyl, -cyclopropyl, -cyclobutyl, -cyclopentyl, -cyclohexyl, or -hydroxy, (v) -amino optionally substituted with one or more C 1 to C 6 alkyl(s), cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl, (vi) —NR i SO 2 R x , where R x is as defined above and R i is: -hydrogen, —C 1 to C 6 alkyl, -cyclopropyl, -cyclobutyl, -cyclopentyl, -cyclohexyl, —COR x , where R x is as defined above, -haloalkyl, or -haloalkoxy,

(vii) —NR j COR k , where R k is: —C 1 to C 6 alkyl, -cyclopropyl, -cyclobutyl, -cyclopentyl, -cyclohexyl, -hydrogen, or -amino optionally substituted with one or more C 1 to C 6 alkyl(s), cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl, and R j is: -hydrogen, —C 1 to C 6 alkyl, -cyclopropyl, -cyclobutyl, -cyclopentyl, -cyclohexyl, —COR x , where R x is as defined above, -haloalkyl, or -haloalkoxy, (viii) —N═N + ═N − , or (ix) —COR l , where R l is a 5 or 6 membered heterocycle optionally substituted with a hydroxy,

(2) -amino optionally substituted with one or more C 1 to C 6 alkyl(s), cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl,

(3) —C 1 to C 6 alkyl, -cyclopropyl, -cyclobutyl, -cyclopentyl, or -cyclohexyl, optionally substituted with: —NHSO 2 R x , where R x is as defined above, or —NR x SO 2 R x , where R x is as defined above,

(4) -haloalkoxy,

(5) -halogen,

(6) -hydroxy,

(7) —COOR x , where R x is as defined above,

(8) —COR m , where R m is: (i) -amino optionally substituted with one or more C 1 to C 6 alkyl(s), cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl, where the one or more C 1 to C 6 alkyl(s), cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl is optionally substituted with: -hydroxy, -5 or 6 membered heterocycle, -amino optionally substituted with one or more C 1 to C 6 alkyl(s), cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, or -alkoxy, (ii) -3 to 7 membered heterocycle, optionally substituted with a C 1 to C 6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl, wherein C 1 to C 6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl is optionally substituted with a dialkyl-amino, —N-cyclopropyl-N-alkyl-amino, —N-cyclobutyl-N-alkyl-amino, —N-cyclopentyl-N-alkyl-amino, —N-cyclohexyl-N-alkyl-amino, or (iii) —NHR n , where R n is: —CH 2 CONH 2 , or -aryl optionally substituted with: —C 1 to C 6 alkyl, -cyclopropyl, -cyclobutyl, -cyclopentyl, -cyclohexyl, -one or more halogen(s), -nitro, or -one or more alkoxy(s),

(9) —NR o COR p , where R p is: (i) —C 1 to C 6 alkyl, -cyclopropyl, -cyclobutyl, -cyclopentyl or -cyclohexyl, optionally substituted with: -halogen, -alkoxy, or -aryl, (ii) -5 or 6 membered heterocycle, (iii) -aryl, optionally substituted with a halogen, (iv) -5 or 6 membered heteroaryl optionally substituted with one or more C 1 to C 6 alkyl(s), cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl, (v) hydrogen, or

 and where R o is:

(i) -hydrogen, (ii) —C 1 to C 6 alkyl, -cyclopropyl, -cyclobutyl, -cyclopentyl or -cyclohexyl, (iii) —COR x , where R x is as defined above, (iv) -haloalkyl, or (v) -haloalkoxy,

(10) —NR q CONR q R r , where R q is: (i) -hydrogen, (ii) —C 1 to C 6 alkyl, -cyclopropyl, -cyclobutyl, -cyclopentyl or -cyclohexyl, (iii) -haloalkyl, (iv) -haloalkoxy, or (v) —COR x , where R x is as defined above, and where R r is:

(i) -aryl optionally substituted with:

—C 1 to C 6 alkyl, -cyclopropyl, -cyclobutyl, -cyclopentyl, -cyclohexyl, -haloalkyl, —OR s , where R s is aryl, or —COOR x , where R x is as defined above, (ii) —C 1 to C 6 alkyl, -cyclopropyl, -cyclobutyl, -cyclopentyl, or -cyclohexyl, optionally substituted with one or more of the following: -halogen, -alkenyl, -aryl, or —COOR x , where R x is as defined above, (iii) —COOR x , where R x is as defined above, (iv) -cyclopropyl, (v) -cyclobutyl, (vi) -cyclopentyl, (vii) -cyclohexyl or (viii) -cyclopropylmethyl,

(11) —NR t COOR u , where R u is: (i) —C 1 to C 12 alkyl, -cyclopropyl, -cyclobutyl, -cyclopentyl, or -cyclohexyl, wherein C 1 to C 12 alkyl, -cyclopropyl, -cyclobutyl, -cyclopentyl, or -cyclohexyl is optionally substituted with: (a) -aryl optionally substituted with a C 1 to C 6 alkyl, -cyclopropyl, -cyclobutyl, -cyclopentyl, or -cyclohexyl, or an alkoxy, (b) -alkenyl, (c) -alkoxy, (d) -alkynyl, (e) -halogen, or (f) -5 or 6 membered heterocycle, (ii) aryl, optionally substituted with: -alkoxy, -halogen, —C 1 to C 6 alkyl, -cyclopropyl, -cyclobutyl, -cyclopentyl, or -cyclohexyl, (iii) -5 or 6 membered heterocycle, (iv) -cyclopropyl, (v) -cyclobutyl, (vi) -cyclopentyl, (vii) -cyclohexyl, (viii) -cyclopropylmethyl, or (ix) -cyclopropylethyl, and R t is: (i) -hydrogen, (ii) —C 1 to C 6 alkyl, -cyclopropyl, -cyclobutyl, -cyclopentyl, or -cyclohexyl, (iii) —COR x , where R x is as defined above, (iv) -haloalkyl, or (v) -haloalkoxy,

(12) —NR v SO 2 R w , where R v is: (i) -hydrogen, (ii) —COR x , where R x is as defined above, or (iii) —C 1 to C 6 alkyl, -cyclopropyl, -cyclobutyl, -cyclopentyl, or -cyclohexyl, wherein C 1 to C 6 alkyl, -cyclopropyl, -cyclobutyl, -cyclopentyl, or -cyclohexyl is optionally substituted with: -halogen, —COR x , where R x is as defined above, —OCOR x , where R x is as defined above, -hydroxy, or -alkoxy, and where R w is: (i) —C 1 to C 6 alkyl, -cyclopropyl, -cyclobutyl, -cyclopentyl, or -cyclohexyl, wherein C 1 to C 6 alkyl, -cyclopropyl, -cyclobutyl, -cyclopentyl, or -cyclohexyl is optionally substituted with: -halogen, -haloalkyl, -aryl, or -5 or 6 membered heterocycle, (ii) —C 2 to C 6 alkenyl, (iii) -mono-alkyl-amino or dialkyl-amino optionally substituted on alkyl with a halogen, (iv) —N-cyclopropyl-N-alkyl-amino, (v) —N-cyclobutyl-N-alkyl-amino, (vi) —N-cyclopentyl-N-alkyl-amino, (vii) —N-cyclohexyl-N-alkyl-amino; (viii) -5 or 6 membered heterocycle, or (ix)-5 or 6 membered heteroaryl optionally substituted with: —C 1 to C 6 alkyl, -cyclopropyl, -cyclobutyl, -cyclopentyl, or -cyclohexyl, -5 or 6 membered heterocycle, or

 optionally substituted with a C 1 to C 6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl, where R y is a C 1 to C 6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, or hydrogen,

 where R z is hydrogen or a C 1 to C 6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl, optionally substituted with aryl,

(20) —SR x , where R x is as defined above,

(21) —SO 2 R aa , where R aa is: (i) —C 1 to C 6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl, (ii) -amino, (iii) -mono-alkyl-amino or dialkyl-amino optionally substituted on alkyl with a hydroxy or a —COOR x , where R x is as defined above, (iv) —N-cyclopropyl-N-alkyl-amino, (v) —N-cyclobutyl-N-alkyl-amino, (vi) —N-cyclopentyl-N-alkyl-amino, (vii) —N-cyclohexyl-N-alkyl-amino; or (viii) -5 or 6 membered heteroaryl,

(22) -aryl, or

(23) —NHR bb , where R bb is:

(iii) —C(═S)NH 2 , or (iv) —PO(OR x ) 2 , where R x is as defined above;

Z is: (a) —C 1 to C 6 alkyl, -cyclopropyl, -cyclobutyl, -cyclopentyl, or -cyclohexyl, optionally substituted with:

(1)-alkoxy, (2) -one or more halogen(s), or (3) -aryl;

(b) —C 2 to C 6 alkenyl;

(c) -aryl optionally substituted with an alkoxy or one or more C 1 to C 6 alkyl(s), cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl;

(d) —COOR x , where R x is as defined above;

(f) -cyclopropylmethyl;

(g) -cyclobutylmethyl; or

(h) -cyclopentylmethyl;

R is: (a) -hydrogen;

(b) -halogen; or

(c) -alkoxy;

R 1 is: (a)-hydrogen;

(b) -hydroxy;

(c) -halogen;

(d) -haloalkyl;

(e) -nitro;

(f) -5 or 6 membered heteroaryl;

(g) -5 or 6 membered heterocycle;

(h) -alkoxy optionally substituted with: (1) -one or more halogen(s), (2) -aryl, or (3) -5 or 6 membered heterocycle;

(i) -aryl optionally substituted with an alkoxy;

(j) —COR x , where R x is as defined above;

(k) —C 1 to C 6 alkyl, -cyclopropyl, -cyclobutyl, -cyclopentyl, or -cyclohexyl, optionally substituted with (i) a dialkyl-amino (ii) —N-cyclopropyl-N-alkyl-amino, (iii) —N-cyclobutyl-N-alkyl-amino, (iv) —N-cyclopentyl-N-alkyl-amino, or (v) —N-cyclohexyl-N-alkyl-amino; or (vi) a 5 or 6 membered heterocycle;

R 2 is: (a)-nitro;

(b) -hydrogen;

(c) -halogen;

(d) -hydroxy;

(e) —C 1 to C 6 alkyl, -cyclopropyl, -cyclobutyl, -cyclopentyl, or -cyclohexyl, optionally substituted with one or more halogen(s);

(f) -amino;

(g) -alkoxy optionally substituted with: (1) -one or more halogen(s), (2) —OCOOR x , where R x is as defined above, (3) -dialkyl-amino optionally substituted on alkyl with an alkoxy, (4) —N-cyclopropyl-N-alkyl-amino, (5) —N-cyclobutyl-N-alkyl-amino, (6) —N-cyclopentyl-N-alkyl-amino, (7) —N-cyclohexyl-N-alkyl-amino; (8) -5 or 6 membered heterocycle optionally substituted with a C 1 to C 6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl, (9) -5 or 6 membered heteroaryl, or (10) -aryl;

(h) —COOR x , where R x is as defined above;

(i) -haloalkyl;

(j) -amide optionally substituted with: (1) -hydroxy, or (2) -aryl;

(k) -5 or 6 membered heteroaryl;

(l) —OCOR x , where R x is as defined above;

(m) —NHCOR jj , where R jj is: (1) -alkoxy, or (2) -amino optionally substituted with one or more C 1 to C 6 alkyl(s), cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl;

(n) —OR kk , where R kk is a 5 to 6 membered heteroaryl; or

(o) —NHSO 2 R x , where R x is as defined above; and

R 3 is:

(a) -hydrogen; or

(b) —CH 2 OCOR x , and R x is as defined above.

2. The compound of claim 1 , wherein:

Y is (a) aryl substituted with one or more of the following:

(1) -amino optionally substituted with one or more C 1 to C 6 alkyl(s), cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl,

(2) —C 1 to C 6 alkyl, -cyclopropyl, -cyclobutyl, -cyclopentyl, or -cyclohexyl, optionally substituted with a —NHSO 2 R x , where R x is as defined above,

(3) —NR o COR p , where R p is: (i) —C 1 to C 6 alkyl, -cyclopropyl, -cyclobutyl, -cyclopentyl, or -cyclohexyl, optionally substituted with: halogen, or -aryl, or (ii) -5 or 6 membered heterocycle, and where R o is a hydrogen,

(4) —NR q CONR q R r , where R q is: (i) -hydrogen, or (ii) —C 1 to C 6 alkyl, -cyclopropyl, -cyclobutyl, -cyclopentyl, or -cyclohexyl, and where R r is a C 1 to C 6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl, optionally substituted with one or more of the following: (a) -halogen, (b) -alkenyl, or (c) -aryl, (iii) -cyclopropyl; (iv) -cyclobutyl; (v) -cyclopentyl; (vi) -cyclohexyl; or (vii) -cyclopropylmethyl;

(5) —NR t COOR u , where R u is: (i) —C 1 to C 12 alkyl, -cyclopropyl, -cyclobutyl, -cyclopentyl, or -cyclohexyl, optionally substituted with: (a)-aryl optionally substituted with a C 1 to C 6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, or an alkoxy, (b) -alkenyl, (c) -alkoxy, (d) -alkynyl, (e) -halogen, or (f) -5 or 6 membered heterocycle, (ii) -aryl, optionally substituted with an alkoxy, (iii) -5 or 6 membered heterocycle, (iv) -cyclopropyl, (v) -cyclobutyl, (vi) -cyclopentyl, (vii) -cyclohexyl, (viii) -cyclopropylmethyl, or (ix)-cyclopropylethyl, and where R t is: (i) -hydrogen, or (ii) —C 1 to C 6 alkyl, -cyclopropyl, -cyclobutyl, -cyclopentyl, or -cyclohexyl,

(6) —NR v SO 2 R w , where R v is a hydrogen, and where R w is a C 1 to C 6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl, optionally substituted with a halogen;

where R z is a C 1 to C 6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl, or (13) —NHR bb , where R bb is a —PO(OR x ) 2 .

3. The compound of claim 1 , wherein:

Z is: (a)-cyclopropyl;

(b) -cyclobutyl;

(c) -cyclopentyl;

(d) -cyclohexyl;

(e) -cyclopropylmethyl;

(f) -cyclobutylmethyl; or

(g) -cyclopentylmethyl.

4. The compound of claim 3 , wherein:

Z is: (a) -cyclopropyl;

(b) -cyclobutyl;

(c) -cyclopentyl;

(d) -cyclohexyl; or

(e) -cyclopropylmethyl.

5. A pharmaceutical composition comprising the compound of claim 1 or a pharmaceutically acceptable salt thereof and one or more pharmaceutically acceptable excipients.

6. A method for treating a viral infection in a subject in need thereof comprising administering an effective amount of the compound of claim 1 or a pharmaceutically acceptable salt thereof to the subject, wherein said viral infection is a Hepatitis C viral infection.

7. A compound or a pharmaceutically acceptable salt thereof selected from the group consisting of:

8. A pharmaceutical composition comprising the compound of claim 7 or a pharmaceutically acceptable salt thereof and one or more pharmaceutically acceptable excipients.

9. A method for treating a viral infection in a subject in need thereof comprising administering an effective amount of the compound of claim 7 or a pharmaceutically acceptable salt thereof to the subject, wherein said viral infection is a Hepatitis C viral infection.