Anti-viral compounds

1. A compound, a tautomer of the compound, or a pharmaceutically acceptable salt of the compound or tautomer, wherein the compound has Formula I(b),

wherein:

Z is —NR 41 —;

A is C 6 carbocyclyl;

R 10 , R 17 , R 31 , R 33 , R 35 and R 41 are each hydrogen;

X is selected from the group consisting of —O—, and —S— and is ortho to Z;

R 22 is carbocyclyl, heterocyclyl, carbocyclylalkyl or heterocyclylalkyl, and is optionally substituted with one or more R 26 , wherein R 26 is independently selected at each occurrence from the group consisting of halogen, oxo, thioxo, hydroxy, mercapto, nitro, cyano, amino, carboxy, formyl, phosphate, azido, alkyl, alkenyl, alkynyl, -L S -O—R S , -L S -S—R S , -L S -C(O)R S , -L S -OC(O)R S , -L S -C(O)OR S , -L S -N(R S R S′ ), -L S -C(═NR S )R S′ , -L S -S(O)R S , -L S -SO 2 R S , -L S -OS(O)R S , -L S -OSO 2 R S , -L S -C(O)N(R S R S′ ), -L S -N(R S )C(O)R S′ , -L S -C(═NR S )N(R S′ R S″ ), -L S -N(R S′ )C(═NR S )R S′ , -L S -N(R S )C(O)N(R S′ R S′ ), -L S -N═C(NR S R S′ )(NR S′ R S′ ), -L S -N(R S )SO 2 R S′ , -L S -SO 2 N(R S R S′ ), -L S -N(R S )SO 2 N(R S′ R S′ ), -L E -Q-L E′ -(C 3 -C 18 -carbocyclyl) and -L E -Q-L E′ -(M 3 -M 18 heterocyclyl); or R 22 is alkyl, alkenyl or alkynyl, and is optionally substituted with one or more R 26 ; or R 22 is hydrogen;

Y is selected from the group consisting of a bond, -L S -O—, -L S -C(O)—, -L S -S(O) 2 —, -L S -S(O)—, -L S -OS(O) 2 —, -L S -OS(O)—, -L S -C(O)O—, -L S -OC(O)—, -L S -OC(O)O—, -L S -C(O)N(R 15 )—, -L S -N(R 15 )C(O)—, -L S -C(O)N(R 15 )O—, -L S -N(R 15 )C(O)O—, -L S -C(O)N(R 15 )N(R 15′ )—, -L S -S—, -L S -C(S)—, -L S -C(S)O—, -L S -OC(S)—, -L S -C(S)N(R 15 )—, -L S -N(R 15 )—, -L S -N(R 15 )C(S)—, -L S -N(R 15 )S(O)—, -L S -N(R 15 )S(O) 2 —, -L S -S(O) 2 N(R 15 )—, -L S -S(O)N(R 15 )—, -L S -C(S)N(R 15 )O—, and -L S -C(S)N(R 15 )N(R 15′ )—, wherein R 15 and R 15′ are each independently selected at each occurrence from the group consisting of hydrogen, alkyl, alkenyl and alkynyl;

R 50 is -L 1 -A 1 , wherein A 1 is selected from the group consisting of carbocyclyl, heterocyclyl, alkyl, alkenyl and alkynyl, and L 1 is selected from the group consisting of a bond, alkylene, alkenylene and alkynylene, wherein A 1 is optionally substituted with one or more R 30 , and R 30 is independently selected at each occurrence from the group consisting of halogen, oxo, thioxo, hydroxy, mercapto, nitro, cyano, amino, carboxy, formyl, phosphate, azido, alkyl, alkenyl, alkynyl, -L S -O—R S , -L S -S—R S , -L S -C(O)R S , -L S -OC(O)R S , -L S -C(O)OR S , -L S -N(R S R S′ ), -L S -C(═NR S )R S′ , -L S -S(O)R S , -L S -SO 2 R S , -L S -C(O)N(R S R S′ ), -L S -N(R S )C(O)R S′ , -L S -C(═NR S )N(R S′ R S″ ), -L S -N(R S′ )C(═NR S )R S″ , -L S -N(R S )C(O)N(R S′ R S″ ), -L S -N(R S )SO 2 R S′ , -L S -SO 2 N(R S R S′ ), -L S -N(R S )SO 2 N(R S′ R S″ ), -L E -Q-L E′ -(C 3 -C 18 -carbocyclyl) and -L E -Q-L E′ -(M 3 -M 18 heterocyclyl), and wherein L 1 is optionally substituted with one or more R 38 , and R 38 is independently selected at each occurrence from the group consisting of halogen, oxo, thioxo, hydroxy, mercapto, nitro, cyano, amino, carboxy, formyl, phosphate, azido, alkoxy, thioalkoxy, alkylcarbonyl, alkoxycarbonyl, alkylcarbonyloxy, alkylamino, alkoxycarbonylamino, -L S -O—R S , -L S -S—R S , -L S -C(O)R S , -L S -OC(O)R S , -L S -C(O)OR S , -L S -N(R S R S′ ), -L S -C(═NR S )R S′ , -L S -S(O)R S , -L S -SO 2 R S , -L S -C(O)N(R S R S′ ), -L S -N(R S )C(O)R S′ , -L S -C(═NR S )N(R S′ R S′ ), -L S -N(R S′ )C(═NR S )R S″ , -L S -N(R S )C(O)N(R S′ ,R S″ ), -L S -N(R S )SO 2 R S′ , -L S -SO 2 N(R S R S′ ), -L S -N(R S )SO 2 N(R S′ R S″ ), carbocyclyl, heterocyclyl, carbocyclylalkyl, heterocyclylalkyl, -L E -Q-L E -(C 3 -C 18 -carbocyclyl) and -L E -Q-L E -(M 3 -M 18 heterocyclyl);

L S is independently selected at each occurrence from the group consisting of a bond, alkylene, alkenylene and alkynylene;

R S , R S′ and R S″ are each independently selected at each occurrence from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, alkoxy, thioalkoxy, alkoxyalkyl, alkoxyalkoxyalkyl, thioalkoxyalkyl, alkylcarbonyl, alkylcarbonylalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkylcarbonyloxy, alkylcarbonyloxyalkyl, alkylamino, alkylaminoalkyl, alkoxycarbonylamino, and alkoxycarbonylaminoalkyl;

L E and L E′ are each independently selected at each occurrence from the group consisting of a bond, alkylene, alkenylene, alkynylene, -alkylene-O-alkylene-, -alkylene-S-alkylene-, -alkylene-NC(O)-alkylene-, and -alkylene-C(O)N-alkylene-;

Q is independently selected at each occurrence from the group consisting of a bond, alkylene, alkenylene, alkynylene, —S—, —O—, C(O)—, —N(R S )—, —N(R S )C(O)—, —C(O)N(R S )—, —N(R S )C(O)O—, —OC(O)N(R S )—, —N(R S )C(O)N(R S′ )—, —C(═NR S )N(R S′ )—, —N(R S′ )C(═NR S )—, —S(O)—, —SO 2 —, —O—SO 2 —, —SO 2 —O—, —S(O)—, —S(O)—O—, —C(O)O— and —C(O)—;

R 15 , R 15′ , R 26 , R 30 and R 38 are each independently optionally substituted at each occurrence with at least one substituent selected from the group consisting of halogen, oxo, thioxo, hydroxy, mercapto, nitro, cyano, amino, carboxy, formyl, phosphate, alkoxy, alkylamino, alkoxycarbonyl, and azido; and

each C 3 -C 18 carbocyclyl and M 3 -M 18 heterocyclyl moiety in -L E -Q-L E′ -(C 3 -C 18 carbocyclyl) and -L E -Q-L E′ -(M 3 -M 18 heterocyclyl) is independently optionally substituted at each occurrence with at least one substituent selected from the group consisting of hydrogen, halogen, oxo, thioxo, hydroxy, mercapto, nitro, cyano, amino, carboxy, formyl, phosphate, azido, alkyl, alkenyl, alkynyl, alkoxy, thioalkoxy, alkoxyalkyl, thioalkoxyalkyl, alkylcarbonyl, alkylcarbonylalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkylcarbonyloxy, alkylcarbonyloxyalkyl, alkylamino, alkylaminoalkyl, alkoxycarbonylamino, carbocyclyloxy, heterocyclyloxy, carbocycloalkoxy, heterocycloalkoxy, carbocycloalkoxycarbonyl, heterocycloalkoxycarbonyl, and alkoxycarbonylaminoalkyl.

2. The compound, tautomer, or salt of claim 1 , wherein:

R 22 is carbocyclyl, heterocyclyl, carbocyclylC 1 -C 6 alkyl or heterocyclylC 1 -C 6 alkyl, and is optionally substituted with one or more R 29 , wherein R 26 is independently selected at each occurrence from the group consisting of halogen, oxo, thioxo, hydroxy, mercapto, nitro, cyano, amino, carboxy, formyl, phosphate, azido, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, -L S -O—R S , -L S -S—R S , -L S -C(O)R S , -L S -OC(O)R S , -L S -C(O)OR S , -L S -N(R S R S′ ), -L S -C(═NR S )R S′ , -L S -S(O)R S , -L S -SO 2 R S , -L S -OS(O)R S , -L S -OSO 2 R S , -L S -C(O)N(R S R S′ ), -L S -N(R S )C(O)R S′ , -L S -C(═NR S )N(R S′ R S″ ), -L S -N(R S′ )C(═NR S )R S″ , -L S -N(R S )C(O)N(R S′ R S″ ), -L S -N═C(NR S R S′ )(NR S R S′ ), -L S -N(R S )SO 2 R S′ , -L S -SO 2 N(R S R S′ ), -L S -N(R S )SO 2 N(R S′ ,R S″ ), -L E -Q-L E′ -(C 3 -C 18 carbocyclyl) and -L E -Q-L E -(M 3 -M 18 heterocyclyl); or R 22 is C 1 -C 6 alkyl, C 2 -C 6 alkenyl or C 2 -C 6 alkynyl, and is optionally substituted with one or more R 26 ; or R 22 is hydrogen;

Y is selected from the group consisting of a bond, -L S -O—, -L S -C(O)—, -L S -S(O) 2 —, -L S -S(O)—, -L S -OS(O) 2 —, -L S -OS(O)—, -L S -C(O)O—, -L S -OC(O)—, -L S -OC(O)O—, -L S -C(O)N(R 15 )—, -L S -N(R 15 )C(O)—, -L S -C(O)N(R 15 )O—, -L S -N(R 15 )C(O)O—, -L S -C(O)N(R 15 )N(R 15′ )—, -L S -S—, -L S -C(S)—, -L S -C(S)O—, -L S -OC(S)—, -L S -C(S)N(R 15 )—, -L S -N(R 15 )—, -L S -N(R 15 )C(S)—, -L S -N(R 15 )S(O)—, -L S -N(R 15 )S(O) 2 —, -L S -S(O) 2 N(R 15 )—, -L S -S(O)N(R 15 )—, -L S -C(S)N(R 15 )O—, and -L S -C(S)N(R 15 )N(R 15′ )—, wherein R 15 and R 15′ are each independently selected at each occurrence from the group consisting of hydrogenC 1 -C 6 alkyl, C 2 -C 6 alkenyl and C 2 -C 6 alkynyl;

R 50 is -L 1 -A 1 , wherein A 1 is selected from the group consisting of carbocyclyl, heterocyclyl, C 1 -C 6 alkyl, C 2 -C 6 alkenyl and C 2 -C 6 alkynyl, and L 1 is selected from the group consisting of a bond, C 1 -C 6 alkylene, C 2 -C 6 alkenylene and C 2 -C 6 alkynylene, wherein A 1 is optionally substituted with one or more R 30 , and R 30 is independently selected at each occurrence from the group consisting of halogen, oxo, thioxo, hydroxy, mercapto, nitro, cyano, amino, carboxy, formyl, phosphate, azido, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, -L S -O—R S , -L S -S—R S , -L S -C(O)R S , -L S -OC(O)R S , -L S -C(O)OR S , -L S -N(R S R S′ ), -L S -C(═NR S )R S′ , -L S -S(O)R S , -L S -SO 2 R S , -L S -C(O)N(R S R S′ ), -L S -N(R S )C(O)R S′ , -L S -C(═NR S )N(R S′ R S″ ), -L S -N(R S′ )C(═NR S )R S″ , -L S -N(R S )C(O)N(R S′ R S″ ), -L S -N(R S )SO 2 R S′ , -L S -SO 2 N(R S R S′ ), -L S -N(R S )SO 2 N(R S′ R S″ ), -L E -Q-L E′ -(C 3 -C 18 carbocyclyl) and -L E -Q-L E -(M 3 -M 18 heterocyclyl), and wherein L 1 is optionally substituted with one or more R 38 , and R 38 is independently selected at each occurrence from the group consisting of halogen, oxo, thioxo, hydroxy, mercapto, nitro, cyano, amino, carboxy, formyl, phosphate, azido, C 1 -C 6 alkoxy, C 1 -C 6 thioalkoxy, C 1 -C 6 alkylcarbonyl, C 1 -C 6 alkoxycarbonyl, C 1 -C 6 alkylcarbonyloxy, C 1 -C 6 alkylamino, C 1 -C 6 alkoxycarbonylamino, -L S -O—R S , -L S -S—R S , -L S -C(O)R S , -L S -OC(O)R S , -L S -C(O)OR S , -L S -N(R S R S′ ), -L S -C(═NR S )R S′ , -L S -S(O)R S , -L S -SO 2 R S , -L S -C(O)N(R S R S′ ), -L S -N(R S )C(O)R S′ , -L S -C(═NR S )N(R S′ R S″ ), -L S -N(R S′ )C(═NR S )R S″ , -L S -N(R S )C(O)N(R S′ R S″ ), -L S -N(R S )SO 2 R S′ , -L S -SO 2 N(R S R S′ ), -L S -N(R S )SO 2 N(R S′ R S″ ), carbocyclyl, heterocyclyl, carbocyclylC 1 -C 6 alkyl, heterocyclylC 1 -C 6 alkyl, -L E -Q-L E′ -(C 3 -C 18 carbocyclyl) and -L E -Q-L E -(M 3 -M 18 heterocyclyl);

L S is independently selected at each occurrence from the group consisting of a bond, C 1 -C 6 alkylene, C 2 -C 6 alkenylene and C 2 -C 6 alkynylene;

R S , R S′ and R S″ are each independently selected at each occurrence from the group consisting of hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 alkoxy, C 1 -C 6 thioalkoxy, C 1 -C 6 alkoxyC 1 -C 6 alkyl, C 1 -C 6 alkoxyC 1 -C 6 alkoxyC 1 -C 6 alkyl, C 1 -C 6 thioalkoxyC 1 -C 6 alkyl, C 1 -C 6 alkylcarbonyl, C 1 -C 6 alkylcarbonylC 1 -C 6 alkyl, C 1 -C 6 alkoxycarbonyl, C 1 -C 6 alkoxycarbonylC 1 -C 6 alkyl, C 1 -C 6 alkylcarbonyloxy, C 1 -C 6 alkylcarbonyloxyC 1 -C 6 alkyl, C 1 -C 6 alkylamino, C 1 -C 6 alkylaminoC 1 -C 6 alkyl, C 1 -C 6 alkoxycarbonylamino, and C 1 -C 6 alkoxycarbonylaminoC 1 -C 6 alkyl;

L E and L E′ are each independently selected at each occurrence from the group consisting of a bond, C 1 -C 6 alkylene, C 2 -C 6 alkenylene and C 2 -C 6 alkynylene, —C 1 -C 6 alkylene-O—C 1 -C 6 alkylene-, —C 1 -C 6 alkylene-S—C 1 -C 6 alkylene-, —C 1 -C 6 alkylene-NC(O)—C 1 -C 6 alkylene-, and —C 1 -C 6 alkylene-C(O)N—C 1 -C 6 alkylene-;

Q is independently selected at each occurrence from the group consisting of a bond, C 1 -C 6 alkylene, C 2 -C 6 alkenylene, C 2 -C 6 alkynylene, —S—, —O—, C(O)—, —N(R S )—, —N(R S )C(O)—, —C(O)N(R S )—, —N(R S )C(O)O—, —OC(O)N(R S )—, —N(R S )C(O)N(R S′ )—, —C(═NR S )N(R S′ )—, —N(R S′ )C(═NR S )—, —S(O)—, —SO 2 —, —O—SO 2 —, —SO 2 —O—, —O—S(O)—, —S(O)—O—, —C(O)O— and —OC(O)—;

R 15 , R 15′ , R 26 , R 30 and R 38 are each independently optionally substituted at each occurrence with at least one substituent selected from the group consisting of halogen, oxo, thioxo, hydroxy, mercapto, nitro, cyano, amino, carboxy, formyl, phosphate, C 1 -C 6 alkoxy, C 1 -C 6 alkylamino, C 1 -C 6 alkoxycarbonyl, and azido; and

each C 3 -C 18 -carbocyclyl and M 3 -M 18 heterocyclyl moiety in -L E -Q-L E′ -(C 3 -C 18 carbocyclyl) and -L E -Q-L E′ -(M 3 -M 18 heterocyclyl) is independently optionally substituted at each occurrence with at least one substituent selected from the group consisting of hydrogen, halogen, oxo, thioxo, hydroxy, mercapto, nitro, cyano, amino, carboxy, formyl, phosphate, azido, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 alkoxy, C 1 -C 6 thioalkoxy, C 1 -C 6 alkoxyC 1 -C 6 alkyl, C 1 -C 6 thioalkoxyC 1 -C 6 alkyl, C 1 -C 6 alkylcarbonyl, C 1 -C 6 alkylcarbonylC 1 -C 6 alkyl, C 1 -C 6 alkoxycarbonyl, C 1 -C 6 alkoxycarbonylC 1 -C 6 alkyl, C 1 -C 6 alkylcarbonyloxy, C 1 -C 6 alkylcarbonyloxyC 1 -C 6 alkyl, C 1 -C 6 alkylamino, C 1 -C 6 alkylaminoC 1 -C 6 alkyl, C 1 -C 6 alkoxycarbonylamino, C 3 -C 7 -carbocyclyloxy, M 3 -M 7 heterocyclyloxy, C 3 -C 7 -carbocycloC 1 -C 6 alkoxy, M 3 -M 7 heterocycloC 1 -C 6 alkoxy, C 3 -C 7 -carbocycloC 1 -C 6 alkoxycarbonyl, M 3 -M 7 heterocycloC 1 -C 6 alkoxycarbonyl, and C 1 -C 6 alkoxycarbonylaminoC 1 -C 6 alkyl.

3. The compound, tautomer, or salt of claim 1 , wherein Y is -L S -O—, -L S -S—, -L S -C(O)N(R 15 )— or -L S -N(R 15 )C(O)—, R 15 is hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl or C 2 -C 6 alkynyl, and L 1 is C 1 -C 6 alkylene optionally substituted with one or more R 38 , and wherein A 1 is a C 4 -C 6 -carbocyclyl or M 4 -M 6 heterocyclyl and is optionally substituted with one or more R 30 .

4. The compound, tautomer, or salt of claim 1 , wherein Y is -L S -O—, -L S -S—, -L S -C(O)N(R 15 )— or -L S -N(R 15 )C(O)—, R 15 is hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl or C 2 -C 6 alkynyl, and L 1 is a bond, wherein A 1 is a C 4 -C 6 carbocyclyl or M 4 -M 6 heterocyclyl and is optionally substituted with one or more R 30 .

5. The compound, tautomer, or salt of claim 1 , wherein Y is -L S -O—, -L S -S—, -L S -C(O)N(R 15 )— or -L S -N(R 15 )C(O)—, R 15 is hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl or C 2 -C 6 alkynyl, and L 1 is a bond or C 1 -C 6 alkylene optionally substituted with one or more R 38 , wherein A 1 is a bicyclic ring (e.g., a fused bicyclic ring or a bridged bicyclic ring) which has from 6 to 14 ring atoms and is optionally substituted with one or more R 30 .

6. The compound, tautomer, or salt of claim 1 , wherein R 22 is C 5 -C 6 carbocyclyl or M 5 -M 6 heterocyclyl and is optionally substituted with one or more R 26 .

7. The compound, tautomer, or salt of claim 1 , wherein R 22 is

wherein R 48 is hydroxy, amino, C 1 -C 6 alkylamino, C 1 -C 6 alkoxy, C 1 -C 6 alkoxycarbonylamino or C 1 -C 6 alkylcarbonyloxy, and wherein R 22 is optionally substituted with one or more R 26 .

8. A compound, a tautomer of the compound, or a pharmaceutically acceptable salt of the compound or tautomer, wherein the compound has Formula II(b),

wherein:

R 2 is hydrogen;

R 4 is hydrogen;

R 7 is hydrogen;

R 9 is selected from the group consisting of hydrogen, alkyl, alkoxy, haloalkyl, arylalkylamino, hydroxy, alkoxycarbonylaminoalkyl, alkylcarbonyl, amino, halogen, N-[alkylarylamino(arylsulfanyl)arylalkyl]-N-[(alkoxycarbonyl)alkyl]amino, alkoxyarylalkoxy, haloarylalkoxy, nitroarylalkoxy, cyanoarylalkoxy, aryloxyalkyl, haloaryloxyalkyl, cyanoalkoxy, arylalkoxy, alkylarylalkoxy, haloalkylarylaminocarbonyl, alkylaminoarylaminocarbonyl, arylalkoxy, alkylallyloxy, and alkoxycarbonyl;

R 11 is hydrogen;

R 12 is selected from the group consisting of arylsulfanyl, arylsulfinyl, aryloxy, and arylalkoxy; wherein R 12 is optionally substituted with one or more substituents independently selected from R 16 ;

R 16 is selected from the group consisting of hydrogen, halogen, alkyl, alkoxy, hydroxy, aminocarbonyl, alkylaminocarbonyl, amino, alkylcarbonylamino, alkylheteroarylcarbonylamino, heteroarylcarbonylamino, hydroxyheteroarylcarbonylamino, hydroxyalkylheteroarylcarbonylamino, heteroarylcarbonylaminoalkylcarbonylamino, heteroarylalkylcarbonylamino, aryloxyarylalkylcarbonylamino, allylaminocarbonyl, alkoxycarbonyl, hydroxyalkyl, arylaminocarbonyl, hydroxyarylaminocarbonyl, alkoxyalkyl, alkoxyarylaminocarbonyl, azidoalkyl, alkylaminoarylsulfonyloxy, alkylsulfonyloxy, arylalkylsulfonyloxy, alkoxycarbonylalkoxy, hydroxycarbonylalkoxy, cycloalkylcarbonylamino, arylalkoxycarbonylheterocyclecarbonylamino, aryloxy, iminoalkyl, alkylthione, arylalkylcarbonylamino, alkylaryloxyalkylcarbonylamino, arylalkoxyalkylcarbonylamino, heteroarylcarbonylaminoalkylcarbonylamino, heteroarylalkylcarbonylamino, alkylcarbonylheterocyclecarbonylamino, amino, aminocarbonyl, alkylaminocarbonyl, hydroxyalkyl, aminoalkyl, alkoxyalkylaminocarbonyl, hydroxyiminoalkyl, heteroaryl substituted with alkyl, and heteroaryl; and

R 13 is hydrogen.

9. The compound, tautomer, or salt of claim 8 , wherein:

R 12 is selected from the group consisting of

R 14 is selected from the group consisting of hydrogen, halogen, alkyl, alkoxy, hydroxy, aminocarbonyl, alkylaminocarbonyl, amino, alkylcarbonylamino, alkylheteroarylcarbonylamino, heteroarylcarbonylamino, hydroxyheteroarylcarbonylamino, hydroxyalkylheteroarylcarbonylamino, heteroarylcarbonylaminoalkylcarbonylamino, heteroarylalkylcarbonylamino, aryloxyarylalkylcarbonylamino, allylaminocarbonyl, alkoxycarbonyl, hydroxyalkyl, arylaminocarbonyl, hydroxyarylaminocarbonyl, alkoxyalkyl, alkoxyarylaminocarbonyl, and azidoalkyl;

wherein, when R 12 is

then R 16 is selected from the group consisting of hydrogen, halogen, alkyl, alkoxy, hydroxy, aminocarbonyl, alkylaminocarbonyl, amino, alkylcarbonylamino, alkylheteroarylcarbonylamino, heteroarylcarbonylamino, hydroxyheteroarylcarbonylamino, hydroxyalkylheteroarylcarbonylamino, heteroarylcarbonylaminoalkylcarbonylamino, heteroarylalkylcarbonylamino, aryloxyarylalkylcarbonylamino, allylaminocarbonyl, alkoxycarbonyl, hydroxyalkyl, arylaminocarbonyl, hydroxyarylaminocarbonyl, alkoxyalkyl, alkoxyarylaminocarbonyl, azidoalkyl, alkylaminoarylsulfonyloxy, alkylsulfonyloxy, arylalkylsulfonyloxy, alkoxycarbonylalkoxy, hydroxycarbonylalkoxy, cycloalkylcarbonylamino, arylalkoxycarbonylheterocyclecarbonylamino, aryloxy, iminoalkyl, alkylthione, arylalkylcarbonylamino, alkylaryloxyalkylcarbonylamino, arylalkoxyalkylcarbonylamino, heteroarylcarbonylaminoalkylcarbonylamino, heteroarylalkylcarbonylamino, alkylcarbonylheterocyclecarbonylamino, amino, aminocarbonyl, alkylaminocarbonyl, hydroxyalkyl, aminoalkyl, alkoxyalkylaminocarbonyl, hydroxyiminoalkyl, heteroaryl substituted with alkyl, and heteroaryl, and

wherein, when R 12 is

then R 16 is selected from the group consisting of aryloxyarylalkylcarbonylamino, arylaminocarbonyl, arylalkylsulfonyloxy, arylalkoxycarbonylheterocyclecarbonylamino, aryloxy, arylalkylcarbonylamino, and arylalkoxyalkylcarbonylamino.

10. The compound, tautomer, or salt of claim 8 , wherein

R 9 is selected from the group consisting of hydrogen, methyl, methoxy, phenyl, trifluoromethyl, phenylmethylamino, hydroxy, t-butoxy-carbonylaminomethyl, carbonylamino, methylcarbonyl, amino, bromo, chloro, fluoro, methyl[1,8]naphthyridin-4-ylamino-(2-phenylsulfanylphen-5-ylmethyl)amino-(N-t-butoxy-carbonyl-N-methyl), methoxyphenylmethoxy, bromophenylmethoxy, nitrophenylmethoxy, cyanophenylmethoxy, trifluoromethyl, phenoxymethyl, bromophenoxymethyl, cyanomethoxy, phenylmethoxy, methylallyloxy, propoxy, methylphenylmethoxy, methylphenylmethoxy, fluoro-3-methylphenylaminocarbonyl, trifluoromethylphenylaminocarbonyl, trifluoromethylphenylaminocarbonyl, N,N-dimethylaminophenylaminocarbonyl, fluorophenylmethoxy, and chlorophenylmethoxy; and

R 16 is selected from the group consisting of hydrogen, hydroxy, methylcarbonylamino, methyl, isopropyl, fluoro, methoxy, ethoxy, propoxy, isopropoxy, N,N-dimethylamino-naphth-1-ylsulfonyloxy, ethylsulfonyloxy, isopropylsulfonyloxy, methylsulfonyloxy, benzylsulfonyloxy, ethoxycarbonylmethoxy, hydroxycarbonylmethoxy, t-butylcarbonylamino, cyclopropylcarbonylamino, benzyloxycarbonylpyrrolidinylcarbonylamino, phenoxy, methylcarbonylamino, iminoethyl, thionoethyl, (S)-1-phenylpropylcarbonylamino, methylphenoxymethylcarbonylamino, (R)-1-phenyl-1-methoxymethylcarbonylamino, (S)-1-phenyl-1-methoxymethylcarbonylamino, furanylcarbonylaminomethylcarbonylamino, thienylpropylcarbonylamino, methylcarbonylpiperidinylcarbonylamino, amino, aminocarbonyl, N-methylaminocarbonyl, ethoxycarbonylmethoxy, isopropylsulfonyloxy, methylsulfonyloxy, ethylsulfonyloxy, phenylmethylsulfonyloxy, methylcarbonylamino, N-methylaminocarbonyl, hydroxymethyl, aminoethyl, methoxyethylaminocarbonyl, propylaminocarbonyl, N-methoxy-N-methylaminocarbonyl, N,N-diethylaminocarbonyl, N-(2-methoxyethyl)aminocarbonyl, N-ethyl-N-methylaminocarbonyl, N-hydroxy-1-iminoethyl, hydroxyethyl, aminomethyl, N,N-dimethylamino-carbonyl, 2,6-dimethylfuranyl, 1H-[1,2,4]triazolyl, and pyridinyl.

11. A pharmaceutical composition comprising a compound, tautomer or salt according to claim 1 .

12. A pharmaceutical composition comprising a compound, tautomer or salt according to claim 8 .

13. A compound, or tautomer or salt thereof, wherein the compound is selected from the group consisting of (5-Chloro-2-phenoxy-phenyl)-[1,6]naphthyridin-5-yl-amine; and N-{4-[4-Methyl-2-([1,6]naphthyridin-5-ylamino)-phenylsulfanyl]-phenyl}-acetamide.