IP Library Granted Patent US 8,123,707
Granted Patent B2
US 8,123,707 · App. 12/818,452 · Granted Feb 28, 2012

Method and apparatus for connective tissue treatment

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Quick Facts
Patent No.
US 8,123,707
App. No.
12/818,452
Granted
Feb 28, 2012
Kind
B2
Abstract

The invention relates to methods and apparatus for therapeutically treating connective tissue or increasing vascularization in tissue using ultrasound. More particularly, the present invention relates to methods and apparatus which use ultrasound to stimulate growth or healing, or to treating pathologies, of connective tissue, or to increase vascularization in ischaemic or grafted tissue using ultrasound.

Claims (8)

1. A method for stimulating growth or healing, or treating pathologies, of a spinal disc in mammals in need thereof, comprising:

subjecting the affected spinal disc to noninvasive, low intensity pulsed ultrasound with a substantially single frequency between about 1 MHz and about 2 MHz, a pulse width of between about 10 and about 2,000 microseconds, a repetition frequency of about 0.1 to about 10 KHz, and for a duration sufficient to stimulate growth, healing, or repair of the spinal disc.

2. The method of claim 1 wherein the low intensity ultrasound has a frequency of around 1.5 MHz.

3. The method of claim 1 wherein the pulse width is about 200 microseconds.

4. The method of claim 1 , wherein the repetition frequency is about 1 KHz.

5. The method of claim 1 , wherein the intensity of the ultrasound is less than 100 milliwatts/cm 2 .

6. The method of claim 1 , wherein the spinal disc is affected by a degenerative disease.

7. The method of claim 1 , wherein subjecting the affected spinal disc to the noninvasive, low intensity pulsed ultrasound for a duration sufficient to stimulate growth, healing, or repair of the spinal disc comprises subjecting the affected spinal disc to the noninvasive, low intensity pulsed ultrasound for a duration sufficient to stimulate growth, healing, or repair of connective tissue of the spinal disc.

Assignments (7)
RELEASE OF SECURITY INTEREST IN PATENT RIGHTS Recorded Dec 6, 2016
From: CITIZENS BANK, N.A.
To: EXOGEN, INC.
Reel/Frame 040829/0650 →
RELEASE OF SECURITY INTEREST IN PATENT RIGHTS Recorded Dec 6, 2016
From: JPMORGAN CHASE BANK, N.A.
To: EXOGEN, INC.
Reel/Frame 040831/0161 →
SECURITY INTEREST Recorded Oct 20, 2014
From: EXOGEN, INC.
To: JPMORGAN CHASE BANK, N.A.
Reel/Frame 033981/0175 →
SECURITY INTEREST Recorded Oct 12, 2014
From: EXOGEN, INC.
To: CITIZENS BANK, N.A.
Reel/Frame 033934/0121 →
RELEASE OF SECURITY INTEREST Recorded Oct 10, 2014
From: HSBC BANK USA, NATIONAL ASSOCIATION
To: BIOVENTUS LLC; EXOGEN, INC.
Reel/Frame 033931/0581 →
SECURITY AGREEMENT Recorded Jun 12, 2013
From: BIOVENTUS LLC; EXOGEN, INC.
To: HSBC BANK USA, NATIONAL ASSOCIATION
Reel/Frame 030601/0824 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 1, 2011
From: HUCKLE, JAMES WILLIAM; CARTER, ANDREW; COTTON, NICOLAS J.; WALSH, WILLIAM R.; SCARBOROUGH, NELSON; TALISH, ROGER J.
To: EXOGEN, INC.
Reel/Frame 027307/0364 →