Nitric oxide therapies
View Patent ↗A method for delivering nitric oxide therapy to a subject can include administering a composition including a nitric-oxide releasing agent and silica to the subject and releasing a therapeutic amount of nitric oxide from the composition.
1. A method for delivering nitric oxide therapy to a subject comprising:
exposing a composition including a nitric-oxide releasing agent, silica, and an antioxidant to water in a chamber of a gas delivery device that includes an inlet, an outlet, a particle filter at the outlet, and the chamber,
wherein the nitric-oxide releasing agent is polymeric composition including a polymer and at least one nitric oxide releasing N 2 O 2 − functional group,
administering the gas delivery device to the subject;
generating an air flow through the inlet, the composition in the chamber, and the outlet by subject inhalation; and
releasing a therapeutic amount of nitric oxide from the composition into the air flow.
2. The method of claim 1 , wherein the silica prevents toxic compounds from entering the subject.
3. The method of claim 2 , wherein the antioxidant is ascorbic acid, alpha tocopherol, or gamma tocopherol.
4. The method of claim 1 , wherein the composition is an ointment.
5. The method of claim 1 , wherein the composition is incorporated into an adhesive strip.
6. The method of claim 5 , wherein the adhesive strip has a calibrated scale on one surface thereof for accurate measurement of an ointment dosage.
7. The method of claim 1 , wherein the composition is in the form of a gum or lozenge.
8. The method of claim 1 , wherein the delivery device is an inhaler or nasal cartridge.
9. The method of claim 1 , further comprising a foil backing.
10. The method of claim 5 , wherein the foil backing prevents nitric oxide from being released into an external environment.
11. The method of claim 1 , wherein the therapeutic amount of nitric oxide is at least 1 ppm.
12. The method of claim 1 , wherein the therapeutic amount of nitric oxide is at least 100 ppm.
13. The method of claim 1 , wherein the therapeutic amount of nitric oxide is at least 200 ppm.
14. The method of claim 1 , wherein the therapeutic amount of nitric oxide is at least 300 ppm.