Method for treatment of diseases
View Patent ↗The invention provides a method of inhibiting vascular hyperpermeability in an animal in need thereof. The method comprises administering a vascular-hyperpermeability-inhibiting amount of a danazol compound to the animal. The invention also provides a method of modulating the cytoskeleton of an endothelial cell in an animal. The method comprises administering an effective amount of a danazol compound to the animal.
1. A method of treating diabetic nephropathy in a human in need thereof comprising orally administering to the human a vascular-hyperpermeability-inhibiting amount of danazol or a pharmaceutically acceptable salt thereof, wherein the hyperpermeability-inhibiting amount is from 1 mg to 100 mg per day.
2. The method of claim 1 wherein administration of the danazol or a pharmaceutically acceptable salt thereof, is commenced immediately upon diagnosis of the diabetic nephropathy.
3. The method of claim 1 wherein the vascular-hyperpermeability-inhibiting amount is from 10 mg to 90 mg of danazol or a pharmaceutically acceptable salt thereof per day.
4. The method of claim 1 wherein the vascular-hyperpermeability-inhibiting amount of danazol or a pharmaceutically acceptable salt thereof is administered to the human at the appearance of one or more early signs of, or a predisposition to develop, diabetic nephropathy.
5. The method of claim 4 wherein administration of danazol or a pharmaceutically acceptable salt thereof is commenced upon the appearance of hyperfiltration.
6. The method of claim 4 wherein administration of danazol or a pharmaceutically acceptable salt thereof is commenced upon the appearance of microalbuminuria.