Polymorphic Form D of bazedoxifene acetate and methods of preparing same
View Patent ↗The present disclosure relates to polymorphic Form D of bazedoxifene acetate, pharmaceutical compositions and methods of treatment using the same, and methods of preparing the same.
1. A crystalline polymorph (Form D) of bazedoxifene acetate having a powder X-ray diffraction pattern comprising characteristic peaks, in terms of 2⊖, at about 10.6°, 14.0°, 17.1°, 17.5° and 24.2°.
2. The polymorph of claim 1 , wherein the polymorph has a temperature of glass transition between about 166° C. and about 168° C.
3. The polymorph of claim 1 with a Raman spectrum substantially as shown in FIG. 2 .
4. The polymorph of claim 1 with a Raman spectrum comprising one or more characteristic peaks selected from about 1561 cm −1 , about 1589 cm −1 and about 1613 cm −1 .
5. The polymorph of claim 1 with a differential scanning calorimetry trace substantially as shown in FIG. 3 .