Accelerated evaporation process and apparatus utilizing re-circulating loops
View Patent ↗A covered sample plate with wells holding samples to be dried. The cover has through holes that communicate with only a portion of each well. The covered plate is inserted into a cradle of an assembly of cradles that is rotated. The cradle assembly fits into a tub and when rotated the cradles present a sold wall that functions as a centrifugal fan that drives air out through an opening in the tub. The air is dried of solvent and re-circulated back through the through holes in the cover to the sample wells.
1. A cover for a sample plate holding samples in wells having well openings, the covered plate comprising:
a top surface and a bottom surface, the cover extends covering the sample plate;
through openings allowing access from the top surface to the well openings; and extensions that descend below the bottom surface, the extensions positioned so that the through openings align and communicate with a portion of each well opening; and wherein the extensions form channels between the bottom surface and the plate, the channels running from an external opening to the portion of the well openings that are not aligned with the through openings, wherein gas enters the well openings that are aligned with the through openings and interacts with the samples in the wells and exits through the portion of the well openings not aligned with the through openings, and travels via the channels and exits via the external opening.
2. The covered plate of claim 1 wherein each through opening communicates with more than one well.
3. A cradle arranged for carrying a sample plate covered by the cover of claim 1 , wherein the cradle assembly has one side with an opening that aligns with the external opening, and a second side that is a flat solid surface.
4. An assembly of a plurality of cradles of claim 3 , wherein the plurality of cradles are fastened together in a circular fashion suitable for rotating, wherein when the assembly is rotating, the second flat solid side of the cradle functions as a blade of a centrifugal fan.
5. The assembly of claim 4 further comprising a tub into which the assembly fits, the tub having a circular wall that surrounds the assembly, the circular wall having an opening positioned to receive gas exiting from the external opening.
6. A process for drying samples contained in wells of a sample plate, the respective wells having well openings, the process comprising the steps of:
covering the sample plate with a cover having through holes and extensions that descend from a bottom surface of the cover;
directing gas via the through holes into the wells via first portions of the respective well openings; and
directing gas from second portions of the respective well openings to an external opening that is separate from the through holes via channels that are associated with the extensions.
7. The process of claim 6 further comprising the step of channeling gas from one through hole into the first portion of one well opening.