METHODS OF USING SUSTAINED RELEASE AMINOPYRIDINE COMPOSITIONS
A pharmaceutical composition which comprises a therapeutically effective amount of a aminopyridine dispersed in a release matrix, including, for example, a composition that can be formulated into a stable, sustained-release oral dosage formulation, such as a tablet which provides, upon administration to a patient, a therapeutically effective plasma level of the aminopyridine for a period of at about 12 hours and the use of the composition to treat various neurological diseases, including multiple sclerosis. A method of selecting individuals based on responsiveness to a treatment, including, for example, identifying individuals who responded to treatment with a sustained release fampridine composition.
1 . A method to decrease a symptom associated with spinal cord injury (SCl) by use of 4-aminopyridine as set forth herein.
2 . A method of using 4-aminopyridine to normalize a body function that has been impaired by spinal cord injury (SCl), as set forth herein.
3 . A method to provide improvement in one or more of the clinically measured parameters associated with spinal cord injury (SCl) by use of 4-aminopyridine as set forth herein.