IP Library Granted Patent US 7,910,685
Granted Patent B2
US 7,910,685 · App. 12/826,664 · Granted Mar 22, 2011

Hydrolytically degradable polymers and hydrogels made therefrom

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Quick Facts
Patent No.
US 7,910,685
App. No.
12/826,664
Granted
Mar 22, 2011
Kind
B2
Abstract

Conjugates between a protein and a water soluble polymer comprising multiple degradable carbonate linkages are provided.

Claims (12)

1. A carbamate-containing conjugate having the following structure:

X—O—[(CH 2 CH 2 —O) n —CO 2 ] m —(CH 2 CH 2 —O) n —CONH-Protein

wherein:

X is selected from the group consisting of alkyl, alkenyl and aryl;

(n) can range from 2 to 2000;

(m) can range from 2 to 200; and

Protein is both a biologically active agent and a protein having an amino group for formation of the carbamate linkage.

2. The conjugate of claim 1 , wherein X is alkyl.

3. The conjugate of claim 2 , wherein alkyl is methyl.

4. The conjugate of claim 1 , wherein (n) is 5 to 500.

5. The conjugate of claim 1 , wherein (n) is 10 to 50.

6. The conjugate of claim 1 , wherein (m) is 2.

Assignments (4)
RELEASE OF SECURITY INTEREST Recorded Apr 17, 2020
From: TC LENDING, LLC, AS COLLATERAL AGENT
To: NEKTAR THERAPEUTICS
Reel/Frame 053180/0009 →
RELEASE OF SECURITY INTEREST RECORDED AT REEL 28571, FRAME 0141 Recorded Oct 14, 2015
From: WELLS FARGO BANK, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
To: NEKTAR THERAPEUTICS
Reel/Frame 036866/0700 →
GRANT OF SECURITY INTEREST IN UNITED STATES PATENTS Recorded Oct 6, 2015
From: NEKTAR THERAPEUTICS
To: TC LENDING, LLC, AS COLLATERAL AGENT
Reel/Frame 036796/0562 →
GRANT OF SECURITY INTEREST Recorded Jul 17, 2012
From: NEKTAR THERAPEUTICS
To: WELLS FARGO BANK, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
Reel/Frame 028571/0141 →