Hydrolytically degradable polymers and hydrogels made therefrom
View Patent ↗Conjugates between a protein and a water soluble polymer comprising multiple degradable carbonate linkages are provided.
1. A carbamate-containing conjugate having the following structure:
X—O—[(CH 2 CH 2 —O) n —CO 2 ] m —(CH 2 CH 2 —O) n —CONH-Protein
wherein:
X is selected from the group consisting of alkyl, alkenyl and aryl;
(n) can range from 2 to 2000;
(m) can range from 2 to 200; and
Protein is both a biologically active agent and a protein having an amino group for formation of the carbamate linkage.
2. The conjugate of claim 1 , wherein X is alkyl.
3. The conjugate of claim 2 , wherein alkyl is methyl.
4. The conjugate of claim 1 , wherein (n) is 5 to 500.
5. The conjugate of claim 1 , wherein (n) is 10 to 50.
6. The conjugate of claim 1 , wherein (m) is 2.