4-substituted-2-amino-pyrimidine derivatives
View Patent ↗Compounds of the formula wherein R 1 and R 2 are as disclosed herein, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor full or partial agonists. Also disclosed are pharmaceutical compositions, methods for using such compounds and compositions, and processes for preparing the compounds.
1. A compound of formula (IV) or a pharmaceutically acceptable salt thereof,
wherein R A is hydrogen, alkyl, arylalkyl, alkoxycarbonyl, or cycloalkyl, R 1 is hydrogen or methyl, R 7 and R 8 are each independently hydrogen or lower alkyl, u is 0, p is an integer from 0 to 2, and q is an integer from 0 to 2, provided that p and u are not both equal to 0.
2. The compound of claim 1 , selected from the group consisting of:
N 4 -(1-benzylpiperidin-4-yl)pyrimidine-2,4-diamine;
(R)-tert-butyl 3-(2-aminopyrimidin-4-ylamino)pyrrolidine-1-carboxylate;
(R)—N 4 -(pyrrolidin-3-yl)pyrimidine-2,4-diamine;
N 4 -(azetidin-3-yl)pyrimidine-2,4-diamine; and
N 4 -(piperidin-4-yl)pyrimidine-2,4-diamine;
or a pharmaceutically acceptable salt thereof.
3. A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 1 , or a pharmaceutically acceptable salt thereof.