Energy status of an individual by enhanced production of an endogenous fuel source
View Patent ↗The present invention relates to a method of improving the energy status of an individual by enhancing the usage of lactate. Improved lactate usage is accomplished through a composition comprising lactate precursors, adrenergic receptor agonists and insulinotropic agents.
1. A composition for increasing exercise-induced lactate production for energy in a mammal comprising one or more lactate precursors; and one or more insulinotropic agents.
2. The composition of claim 1 further comprising one or more adrenergic agonists.
3. The composition of claim 2 wherein the one or more adrenergic agonists is selected from the group consisting of dopamine, epinephrine and norepinephrine.
4. The composition of claim 3 wherein the dopamine is present in amount from about 0.01 mg to 2 mg, the epinephrine is present in amount from about 0.01 mg to 2 mg or the norepinephrine is present in amount from about 0.01 mg to 2 mg.
5. The composition of claim 3 wherein the lactate precursor is selected from the group consisting of glutamine and pyruvate; and wherein the insulinotropic agent is selected from the group consisting of: leucine, arginine, methyl pyruvate, methyl succinate, and carbohydrate.
6. The composition of claim 5 wherein the lactate precursor is glutamine; and the insulinotropic agent is leucine.
7. The composition of claim 6 wherein the amount of glutamine is from about 0.05 g to about 5.00 g and the amount of leucine is from about 10 mg to about 7.50 g.
8. The composition of claim 5 wherein the lactate precursor is glutamine; and the insulinotropic agent is arginine.
9. The composition of claim 8 wherein the amount of glutamine is from about 0.05 g to about 5.0 g and the amount of arginine is from about 50 mg to about 5.0 g.
10. The composition of claim 5 wherein the lactate precursor is pyruvate; and the insulinotropic agent is leucine.
11. The composition of claim 10 wherein the amount of pyruvate is from about 1 mg to about 1000 mg and the amount of leucine is from about 10 mg to about 7.5 g.
12. The composition of claim 5 wherein the lactate precursor is pyruvate; and the insulinotropic agent is arginine.
13. The composition of claim 12 wherein the amount of pyruvate is from about 1 mg to about 1000 mg and the amount of arginine is from about 50 mg to about 5.0 g.
14. The composition of claim 2 wherein the one or more adrenergic agonists are beta-adrenergic agonists or alpha-adrenergic agonists.
15. The composition of claim 5 wherein the carbohydrate is glucose.
16. A method of increasing exercised-induced lactate production for energy in a mammal comprising the step of administering to the mammal with exercise a composition comprising one or more lactate precursors and one or more insulinotropic agents.
17. The method of claim 16 further comprising one or more adrenergic agonists.
18. The method of claim 17 wherein the one or more adrenergic agonists is selected from the group consisting of dopamine, epinephrine and norepinephrine.
19. The method of claim 18 wherein dopamine is present in amount from about 0.01 mg to 2 mg, epinephrine is present in amount from about 0.01 mg to 2 mg or norepinephrine is present in amount from about 0.01 mg to 2 mg.
20. The method of claim 16 wherein the lactate precursor is selected from the group consisting of glutamine and pyruvate; and the insulinotropic agent is selected from the group consisting of leucine, arginine, methyl pyruvate, methyl succinate, and carbohydrate.
21. The method of claim 20 wherein the lactate precursor is glutamine; and the insulinotropic agent is leucine.
22. The method of claim 21 wherein the amount of glutamine is from about 0.05 g to about 5.00 g; and the amount of leucine is from about 10 mg to about 7.50 g.
23. The method of claim 20 wherein the lactate precursor is glutamine; and the insulinotropic agent is arginine.
24. The method of claim 23 wherein the amount of glutamine is from about 0.05 g to about 5.0 g and the amount of arginine is from about 50 mg to about 5.0 g.
25. The method of claim 20 wherein the lactate precursor is pyruvate and the insulinotropic agent is leucine.
26. The method of claim 25 wherein the amount of pyruvate is from about 1 mg to about 1000 mg and the amount of leucine is from about 10 mg to about 7.5 g.
27. The method of claim 20 wherein the lactate precursor is pyruvate and the insulinotropic agent is arginine.
28. The method of claim 27 wherein the amount of pyruvate is from about 1 mg to about 1000 mg and the amount of arginine is from about 50 mg to about 5.0 g.
29. The method of claim 17 wherein the one or more adrenergic agonists are selected from the group consisting of beta-adrenergic agonists or alpha-adrenergic agonists.
30. The method of claim 20 wherein the carbohydrate is glucose.