NOVEL SYNTHETIC GANGLIOSIDE DERIVATIVES AND COMPOSITIONS THEREOF

1 - 22 . (canceled)

23 . A synthetic compound having a formula selected from the group consisting of (Va), (Vb), (Vc) and (Vd):

wherein

the saccharide portion is selected from the group consisting of a monosaccharide, a disaccharide, an oligosaccharide, a polysaccharide, an N-acetylated derivative thereof and an N-deacetylated derivative thereof;

X is NR 1 R 2 ;

Y is —OH;

Z is O;

each R 1 and R 2 are independently selected from the group consisting of —C(=M)R 3 , and —C(=M)-p-R 3 ;

wherein M and p are independently selected from O, NR 4 and S;

R 3 is H, alkyl, arylalkyl, haloalkyl, aryl, heteroaryl, or heteroalkyl;

R 4 is H, alkyl, aryl, arylalkyl, heteroaryl, heteroalkyl, or haloalkyl;

R 6 is H;

R 6′ is —NR 9 R 10 ;

R 6″ is H;

R 7 and R 8 are independently H, and aryl, where, R 7 and R 8 are optionally substituted with at least one group selected from the group consisting of halo, haloalkyl, alkoxy, and thiohaloalkyl;

R 7′ and R 8′ are independently H, alkenyl, —C(═O)NR 9 R 10 , aryl, heteroaryl, or a linked bicyclic mixture of aryl and heteroaryl, where R 7′ and R 8′ are optionally substituted with at least one group selected from the group consisting of halo, haloalkyl, alkoxy, and thiohaloalkyl;

R 9 , R 10 , and R 11 are independently alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, or heteroalkyl, where R 9 , R 10 , and R 11 are optionally substituted, preferably-substituted with at least one group selected from the group consisting of halo, haloalkyl, alkoxy, and thiohaloalkyl; or where R 9 and R 10 taken together with the nitrogen to which they are attached form a heterocyclic ring comprising at least one heteroatom selected from N, O and S;

and all pharmaceutically acceptable salts, hydrates, geometric isomers and solvates thereof.