Ethyleneoxide butyleneoxide block copolymer compositions
View Patent ↗The present invention relates to compositions comprising ethyleneoxide butyleneoxide and a galactomannan such as guar. The compositions are particularly well suited for ophthalmic applications such as contact lens disinfection and rewetting. Methods for the treatment of dry eye using the compositions of the present invention are also contemplated.
1. A sterile, aqueous ophthalmic composition comprising an ethyleneoxide butyleneoxide (EO-BO) block copolymer of the formula (EO) m (BO) n and a galactomannan, and wherein m has an average value of 45 and n has an average value of 9 to 18.
2. A composition according to claim 1 wherein m has an average value of 45 and n has an average value of 9 to 11.
3. A composition according to claim 1 wherein said galactomannan is guar.
4. A composition according to claim 3 wherein said guar or guar derivative is selected from the group consisting of:
native guar, hydroxypropyl guar, and hydroxypropyl guar galactomannan.
5. A composition according to claim 1 wherein said EO-BO block copolymer is present at a concentration of 0.001 to 1.0% w/v.
6. A composition according to claim 1 wherein said EO-BO block copolymer is present at a concentration of 0.01 to 0.1% w/v.
7. A composition according to claim 1 wherein said galactomannan is present at a concentration of 0.01 to 2.0% w/v.
8. A composition according to claim 1 wherein said galactomannan is present at a concentration of 0.05 to 0.25% w/v.
9. A method of delivering a pharmaceutical agent to the eye which comprises topically administering to the eye a composition comprising one or more pharmaceutically active agent(s), an ethyleneoxide butyleneoxide block copolymer of the formula (EO) m (BO) n and a galactomannan, and wherein m has an average value of 45 and n has an average value of 9 to 18.
10. A composition according to claim 9 , wherein the pharmaceutically active agent(s) is/are selected from the group consisting of: anti-glaucoma agents, anti-angiogenesis agents; anti-infective agents; anti-inflammatory agents; growth factors; immunosuppressant agents; and anti-allergic agents.