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Patent Application
App. No. 12/834,368

G-QUADRUPLEX BINDING ASSAYS AND COMPOUNDS THEREFOR

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Quick Facts
Patent No.
US None
App. No.
12/834,368
Abstract

The present invention provides methods for assaying binding of compounds to G-quadruplex structures. Also provided are methods for screening candidate compounds for use as modulators of G-quadruplex activity, and methods for screening candidate compounds for telomerase inhibitory activity. The invention further provides novel compounds useful in the assays of the invention.

Claims (11)

1 . (canceled)

2 . A compound comprising any of SEQ ID NOs: 1-8 wherein at least one G nucleobase therein has been replaced with a 6-methyl-isoxanthopterin nucleobase, provided that said compound forms a G-quadruplex structure;

wherein each 6-methyl-isoxanthopterin nucleobase is located within said G-quadruplex structure;

and wherein each of said 6-methyl-isoxanthopterin nucleobases are located at one or more of the G5 or G11 positions thereof.

3 . The compound of claim 2 , wherein said compound contains one 6-methyl-isoxanthopterin nucleobase.

4 . The compound of claim 2 , wherein said compound contains two 6-methyl-isoxanthopterin nucleobases.

5 . The compound of claim 2 , wherein the compound comprises any of SEQ ID NOs: 2-8.

6 . The compound of claim 2 , wherein the compound comprises any of SEQ ID NOs: 3-5.

7 . The compound of claim 2 , wherein the compound comprises SEQ ID NO: 4.

8 . An array comprising the G-quadruplex analog polynucleotide of claim 2 .

9 . An array comprising the G-quadruplex analog polynucleotide of claim 3 .