Unit dose formulation of antidotes for factor Xa inhibitors and methods of using the same
View Patent ↗The present invention relates unit dose formulations of antidotes to anticoagulants targeting factor Xa. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.
1. A unit dose formulation consisting essentially of a pharmaceutically acceptable carrier and from about 200 milligrams to about 1 gram of a two-chain polypeptide comprising the amino acid sequence of SEQ ID NO. 13.
2. The unit dose formulation of claim 1 , having from about 400 milligrams to about 900 milligrams of the polypeptide.
3. The unit dose formulation of claim 1 , wherein the carrier is saline.
4. The unit dose formulation of claim 3 , wherein the formulation has a concentration of from about 0.2 to about 10 milligrams of polypeptide per milliliter of saline.
5. The unit dose formulation of claim 4 , wherein the formulation has a concentration of about 2 to about 6 milligrams of polypeptide per milliliter of saline.
6. The unit dose formulation of claim 5 , wherein the formulation has a concentration of about 2 milligrams of polypeptide per milliliter of saline.
7. The unit dose formulation of claim 1 , wherein the polypeptide is lyophilized.
8. The unit dose formulation of claim 1 , having about 200, about 400 or about 900 milligrams of the polypeptide.