Pyrrolopyridine inhibitors of kinases

1. A compound having formula (I)

wherein

R 1a and R 1c are independently hydrogen, nitro, halogen, cyano, hydroxy, C 1-6 -alkyl, C 1-6 -haloalkyl, C 1-6 -alkoxy, C 1-6 -haloalkoxy, —NH 2 , —NH(C 1-6 -alkyl), or —N(C 1-6 -alkyl) 2 ;

R 1b is hydrogen, nitro, halogen, cyano, C 1-6 -alkyl, C 1-6 -haloalkyl, —OR a , —NR b R c ; —C(O)OR a , —C(O)NR b R c , —NR b C(O)R c , —NHC(O)NHR b , —NHSO 2 R a , —SO 2 NR b R c , phenyl, or heteroaryl, wherein the phenyl and heteroaryl are optionally substituted with R d ;

X is CR 2 ;

R 2 is hydrogen;

Y is NR 3 R 4 , NR 5 C(O)R 6 , NR 5 SO 2 R 6 , or phenyl, wherein the phenyl is optionally substituted with one or more C 1-6 -alkyl, C 1-6 -haloalkyl, halogen, cyano, hydroxy, C 1-6 -alkoxy, C 1-6 -haloalkoxy, —NH 2 , —NH(C 1-6 -alkyl), or —N(C 1-6 -alkyl) 2 ;

R 3 is hydrogen, C 1-8 -alkyl, C 2-8 -alkenyl, C 1-8 -alkyl-O—C 1-8 -alkyl-, C 3-8 -cycloalkyl, C 3-8 -cycloalkyl-(C 1-8 -alkyl)-, heterocycloalkyl, heterocycloalkyl-(C 1-8 -alkyl)-, aryl, aryl-(C 1-8 -alkyl)-, heteroaryl, or heteroaryl-(C 1-8 -alkyl)-, wherein (a) the R 3 C 1-8 -alkyl and C 2-8 -alkenyl substituents, alone or as part of another moiety, are optionally substituted with one or more substituents selected from the group consisting of halogen, cyano, nitro, —OR e , —C(O)R e , —C(O)OR e , —OC(O)R e , —NR f R g , —NR f C(O)R e , —NHC(O)NHR f , —C(O)NR f R g , —NHSO 2 R e , —SO 2 NR f NR g , and benzyl; and (b) the R 3 C 3-8 -cycloalkyl, heterocycloalkyl, aryl, and heteroaryl, alone or as part of another moiety, are optionally substituted with one or more R 7 ;

R 4 is hydrogen, C 1-6 -alkyl, —C(O)C 1-6 -alkyl, —C(O)C 3-8 -cycloalkyl, —S(O) 2 C 1-6 -alkyl, or —S(O) 2 C 3-8 -cycloalkyl, wherein the R 4 C 1-6 -alkyl is optionally substituted with one or more substituents selected from the group consisting of halogen, hydroxy, C 1-6 -alkoxy, —NH 2 , —NH(C 1-6 -alkyl), and —N(C 1-6 -alkyl) 2 ;

or R 3 and R 4 can be joined together to form a 4-7 membered heterocycloalkyl ring; wherein the heterocycloalkyl ring is optionally substituted with one or more R 7 ;

R 5 is hydrogen or C 1-8 -alkyl;

R 6 is C 1-8 -alkyl, C 2-8 -alkenyl, C 3-8 -cycloalkyl, C 3-8 -cycloalkyl-(C 1-8 -alkyl)-, heterocycloalkyl, heterocycloalkyl-(C 1-8 -alkyl)-, aryl, aryl-(C 1-8 -alkyl)-, heteroaryl, or heteroaryl-(C 1-8 -alkyl)-, wherein (a) the R 6 C 1-8 -alkyl and C 2-8 -alkenyl substituents, alone or as part of another moiety, are optionally substituted with one or more substituents selected from the group consisting of halogen, hydroxy, C 1-6 -alkoxy, C 1-6 -haloalkoxy, —NH 2 , —NH(C 1-6 -alkyl), and —N(C 1-6 -alkyl) 2 , and (b) the R 6 C 3-8 -cycloalkyl, heterocycloalkyl, aryl, and heteroaryl, alone or as part of another moiety, are optionally substituted with one or more substituents selected from the group consisting of C 1-6 -alkyl, C 1-6 -haloalkyl, halogen, cyano, hydroxy, C 1-6 -alkoxy, C 1-6 -haloalkoxy, —NH 2 , —NH(C 1-6 -alkyl), and —N(C 1-6 -alkyl) 2 ;

R 7 is C 1-6 -alkyl, C 1-6 -haloalkyl, C 2-6 -alkenyl, C 3-8 -cycloalkyl, C 3-8 -cycloalkyl-(C 1-4 -alkyl)-, heterocycloalkyl, heterocycloalkyl-(C 1-4 -alkyl)-, aryl, aryl-(C 1-4 -alkyl)-, heteroaryl, heteroaryl-(C 1-4 -alkyl)-, halogen, oxo, cyano, nitro, —OR 8 , —C(O)R 8 , —C(O)OR 8 , —OC(O)R 8 , —SR 8 , —S(O)R 8 , —SO 2 R 8 , —NR 9 R 10 , —NHC(O)R 11 , —NHC(O)NHR 11 , —NHC(O)OR 11 , —NHSO 2 R 11 , —C(O)NHR 11 , or —SO 2 NHNR 11 , wherein the R 7 cycloalkyl, heterocycloalkyl, aryl, and heteroaryl, alone or as part of another moiety, are optionally substituted with one or more R 12 ;

R 8 is hydrogen, C 1-6 -alkyl, C 1-6 -haloalkyl, C 2-6 -alkenyl, C 3-8 -cycloalkyl, aryl, heteroaryl, or heterocycloalkyl;

R 9 is hydrogen, C 1-6 -alkyl, C 1-6 -haloalkyl, C 2-6 -alkenyl, C 3-8 -cycloalkyl, C 3-8 -cycloalkyl-(C 1-4 -alkyl)-, heterocycloalkyl, heterocycloalkyl-(C 1-4 -alkyl)-, aryl, aryl-(C 1-4 -alkyl)-, heteroaryl, heteroaryl-(C 1-4 -alkyl)-, wherein the R 9 cycloalkyl, heterocycloalkyl, aryl, and heteroaryl, alone or as part of another moiety, are optionally substituted with one or more substituents selected from the group consisting of C 1-6 -alkyl, C 3-8 -cycloalkyl, heterocycloalkyl, heterocycloalkyl-(C 1-4 -alkyl)-, —C(O)R h , —C(O)OR h , —NR i R j , and —NHC(O)R j ;

R 10 is hydrogen or C 1-6 -alkyl;

R 11 is C 1-6 -alkyl, C 1-6 -haloalkyl, C 2-6 -alkenyl, C 3-8 -cycloalkyl, C 3-8 -cycloalkyl-(C 1-4 -alkyl)-, heterocycloalkyl, heterocycloalkyl-(C 1-4 -alkyl)-, aryl, aryl-(C 1-4 -alkyl)-, heteroaryl, heteroaryl-(C 1-4 -alkyl)-, —(C 1-4 -alkyl)-NR k R l , —(C 1-4 -alkyl)-NHC(O)R m , —(C 1-4 -alkyl)-NHSO 2 R m , —(C 1-4 -alkyl)-NHC(O)NHR k , —(C 1-4 -alkyl)-OR m , or —(C 1-4 -alkyl)-C(O)OR m , wherein the R 11 C 3-8 -cycloalkyl, heterocycloalkyl, aryl, and heteroaryl, alone or as part of another moiety, are optionally substituted with one or more substituents selected from the group consisting of C 1-6 -alkyl, C 1-6 -haloalkyl, C 1-6 -hydroxyalkyl, halogen, cyano, hydroxy, oxo, C 1-6 -alkoxy, C 1-6 -haloalkoxy, —NH 2 , —NH(C 1-6 -alkyl), —NH(C 3-8 -cycloalkyl), N(C 1-6 -alkyl) 2 , —N(C 1-6 -alkyl)(C 1-6 -hydroxylalkyl), —C(O)OC 1-6 -alkyl, —S(O) 2 C 1-6 -alkyl, heteroaryl, phenyl, benzyl, cycloalkyl, and heterocycloalkyl, wherein the heteroaryl, phenyl, benzyl, cycloalkyl, and heterocycloalkyl are optionally substituted with one or more C 1-6 -alkyl or halogen;

R 12 is selected from the group consisting of C 1-6 -alkyl, C 3-8 -cycloalkyl, —C(O)R n , —C(O)OR n , —NR o R p , —NHC(O)R n , —SO 2 R n , oxo, phenyl, benzyl, and heterocycloalkyl, wherein the phenyl, benzyl, and heterocycloalkyl are optionally substituted with one or more halogen or C 1-6 alkyl;

R a , at each occurrence, is selected from the group consisting of hydrogen, C 1-6 -alkyl, C 1-6 -haloalkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, aryl, heterocycloalkyl, heteroaryl, and C 3-8 -cycloalkyl, wherein the C 1-6 -alkyl, C 2-6 -alkenyl, aryl, heterocycloalkyl, heteroaryl, and C 3-8 -cycloalkyl are optionally substituted with one or more substituents independently selected from the group consisting of C 1-6 -alkyl, aryl, heterocycloalkyl, heteroaryl, C 3-8 -cycloalkyl, halogen, cyano, oxo, hydroxy, C 1-6 -alkoxy, —NH 2 , —NH(C 1-6 -alkyl), and —N(C 1-6 -alkyl) 2 , wherein the heteroaryl is optionally substituted with C 1-6 -alkyl;

R b and R c , at each occurrence, are independently selected from the group consisting of hydrogen, C 1-6 -alkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, aryl, heterocycloalkyl, heteroaryl, and C 3-8 -cycloalkyl, wherein the C 1-6 -alkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, aryl, heterocyclyl, C 3-8 -cycloalkyl are optionally substituted with one or more substituents independently selected from the group consisting of C 1-6 -alkyl, aryl, heterocyclyl, C 3-8 -cycloalkyl, halogen, cyano, oxo, hydroxy, C 1-6 -alkoxy, —NH 2 , —NH(C 1-6 -alkyl), and —N(C 1-6 -alkyl) 2 ;

R d at each occurrence, is selected from the group consisting of C 1-6 -alkyl, —NH 2 , —NH(C 1-6 -alkyl), —N(C 1-6 -alkyl) 2 ; SO 2 NH 2 , heterocycloalkyl-(C 1-4 )—, and —C 1-4 -hydroxyalkyl, wherein the heterocycloalkyl is optionally substituted with C 1-6 -alkyl;

R e , at each occurrence, is selected from the group consisting of hydrogen, C 1-6 -alkyl, C 2-6 -alkenyl, aryl, heteroaryl, heterocycloalkyl, and C 3-8 -cycloalkyl, wherein the C 1-6 -alkyl, C 2-6 -alkenyl, aryl, heteroaryl, heterocycloalkyl, and C 3-8 -cycloalkyl are optionally substituted with one or more substituents independently selected from the group consisting of C 1-6 -alkyl, aryl, heterocyclyl, C 3-8 -cycloalkyl, halogen, cyano, oxo, hydroxy, C 1-6 -alkoxy, —NH 2 , —NH(C 1-6 -alkyl), and —N(C 1-6 -alkyl) 2 ;

R f and R g , at each occurrence, are independently selected from the group consisting of hydrogen, C 1-6 -alkyl, C 2-6 -alkenyl, aryl, heteroaryl, heterocycloalkyl, and C 3-8 -cycloalkyl, wherein the C 1-6 -alkyl, C 2-6 -alkenyl, aryl, heteroaryl, heterocycloalkyl, C 3-8 -cycloalkyl are optionally substituted with one or more substituents independently selected from the group consisting of C 1-6 -alkyl, aryl, heterocyclyl, C 3-8 -cycloalkyl, halogen, cyano, oxo, hydroxy, C 1-6 -alkoxy, —NH 2 , —NH(C 1-6 -alkyl), and —N(C 1-6 -alkyl) 2 ;

R h , at each occurrence, is independently selected from the group consisting of C 1-6 -alkyl, phenyl, benzyl, heterocycloalkyl, and C 3-8 -cycloalkyl;

R i and R j , at each occurrence, are independently selected from the group consisting of hydrogen, C 1-6 -alkyl, phenyl, benzyl, and C 3-8 -cycloalkyl;

R k , at each occurrence, is selected from the group consisting of hydrogen, C 1-6 -alkyl, C 2-6 -alkenyl, aryl, heterocycloalkyl, heteroaryl, and C 3-8 -cycloalkyl, wherein the aryl and heteroaryl are optionally substituted with one or more substituents independently selected from the group consisting of C 1-6 -alkyl and —C(O)C 1-6 -alkyl;

R l , at each occurrence, is selected from the group consisting of hydrogen and C 1-6 -alkyl;

R m , at each occurrence, is selected from the group consisting of hydrogen, C 1-6 -alkyl, C 2-6 -alkenyl, aryl, heterocycloalkyl, heteroaryl, and C 3-8 -cycloalkyl, wherein the aryl and heteroaryl are optionally substituted with one or more substituents independently selected from the group consisting of C 1-6 -alkyl and —C(O)C 1-6 -alkyl;

R n , at each occurrence, is selected from the group consisting of hydrogen, C 1-6 -alkyl, C 2-6 -alkenyl, aryl, heterocyloalkyl, heteroaryl, and C 3-8 -cycloalkyl, wherein the aryl and heteroaryl are optionally substituted with one or more substituents independently selected from the group consisting of C 1-6 -alkyl and —C(O)C 1-6 -alkyl;

R o , at each occurrence, is selected from the group consisting of hydrogen, C 1-6 -alkyl, aryl, heteroaryl, heterocycloalkyl, and C 3-8 -cycloalkyl, wherein the aryl and heteroaryl are optionally substituted with one or more substituents independently selected from the group consisting of C 1-6 -alkyl and —C(O)C 1-6 -alkyl;

R p , at each occurrence, is selected from the group consisting of hydrogen and C 1-6 -alkyl;

or a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 , wherein R 1a , R 1b , and R 1c are each hydrogen.

3. The compound of claim 1 , wherein R 1a and R 1c are hydrogen and R 1b is halogen, cyano, C 1-6 -alkyl, C 1-6 -haloalkyl, —OR a , phenyl, or heteroaryl.

4. The compound of claim 1 , wherein Y is NR 3 R 4 .

5. The compound of claim 4 , wherein R 3 is C 1-8 -alkyl or C 2-8 -alkenyl, wherein the C 1-8 -alkyl or C 2-8 -alkenyl are optionally substituted with one or two substituents selected from the group consisting of —OR e , —NR f R g , —NR f C(O)R e , —NHSO 2 R e , —SO 2 NR f NR g , and benzyl, wherein R e , R f , and R g are independently selected from the group consisting of H, C 1-6 -alkyl, C 3-8 -cycloalkyl, heteroaryl, and phenyl.

6. The compound of claim 4 , wherein R 3 is aryl or heteroaryl, wherein the aryl and heteroaryl are optionally substituted with one or more R 7 , wherein R 7 is C 1-6 -alkyl, C 1-6 -haloalkyl, —OR 8 , —SR 8 , heteroaryl, or heterocycloalkyl, wherein the heteroaryl and heterocycloalkyl are optionally substituted with C 1-6 -alkyl.

7. The compound of claim 4 , wherein R 3 is C 3-8 -cycloalkyl optionally substituted with one or two R 7 , wherein R 7 is heterocycloalkyl, C 3-8 -cycloalkyl-(C 1-4 -alkyl)-, OR 8 , —NR 9 R 10 , —NHC(O)R 11 , —NHC(O)NHR 11 , or —NHSO 2 R 11 .

8. The compound of claim 4 , wherein R 3 is heterocycloalkyl optionally substituted with one or two R 7 , wherein R 7 is —S(O) 2 R 8 , —C(O)R 8 , C 3-8 -cycloalkyl, C 1-6 -alkyl, heterocycloalkyl, or aryl-(C 1-4 -alkyl)-.

9. The compound of claim 4 , wherein R 3 is C 3-8 -cycloalkyl-(C 1-8 -alkyl)-, wherein the R 3 C 3-8 -cycloalkyl is optionally substituted with one or two R 7 , wherein R 7 is heterocycloalkyl, C 3-8 -cycloalkyl-(C 1-4 -alkyl)-, OR 8 , —NR 9 R 10 , —NHC(O)R 11 , —NHC(O)NHR 11 , or —NHSO 2 R 11 .

10. The compound of claim 4 , wherein R 3 is heterocycloalkyl-(C 1-8 -alkyl)-, wherein the R 3 heterocycloalkyl is optionally substituted with one or two R 7 , wherein R 7 is —S(O) 2 R 8 , —C(O)R 8 , C 3-8 -cycloalkyl, C 1-6 -alkyl, heterocycloalkyl, or aryl-(C 1-4 -alkyl)-.

11. The compound of claim 4 , wherein R 3 is aryl-(C 1-8 -alkyl)- or heteroaryl-(C 1-8 -alkyl)-, wherein the R 3 aryl and heteroaryl are optionally substituted with one or two R 7 , wherein R 7 is C 1-6 -alkyl, C 1-6 -haloalkyl, —OR 8 , —SR 8 , heteroaryl, or heterocycloalkyl, wherein the heteroaryl and heterocycloalkyl are optionally substituted with C 1-6 -alkyl.

12. The compound of claim 4 , wherein R 4 is hydrogen.

13. The compound of claim 1 , wherein Y is NR 5 C(O)R 6 or NR 5 SO 2 R 6 , R 5 is hydrogen, and R 6 is C 1-8 -alkyl, C 3-8 -cycloalkyl, heterocycloalkyl, aryl, or heteroaryl.

14. A compound selected from the group consisting of

6-chloro-N-cyclohexyl-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

N-benzyl-6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

N-allyl-6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

3-(2-chloro-6-piperidin-1-ylpyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine;

N-benzyl-6-chloro-N-methyl-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

3-[2-chloro-6-(3,3-difluoroazetidin-1-yl)pyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine;

3-[2-chloro-6-(2,3-dimethylphenyl)pyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine;

6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-N-tetrahydro-2H-pyran-4-ylpyridin-2-amine;

2-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexanol;

6-chloro-N-(2-methoxyethyl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

2-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}ethanol;

6-chloro-N,N-bis(2-methoxyethyl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(tetrahydrofuran-2-ylmethyl)pyridin-2-amine;

Trans 4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexanol;

N-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]cyclohexane-1,4-diamine;

6-chloro-N-(2-methoxycyclohexyl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

N-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]cyclohexane-1,2-diamine;

1-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}-2-methylpropan-2-ol;

4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}butan-1-ol;

5-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}-2,2-dimethylpentan-1-ol;

N-(4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)methanesulfonamide;

N-(4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)acetamide;

N-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]cyclohexane-1,3-diamine;

N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)methanesulfonamide;

6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(tetrahydro-2H-pyran-4-ylmethyl)pyridin-2-amine;

3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexanol;

6-chloro-N-(pyridin-3-ylmethyl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(tetrahydro-2H-pyran-3-ylmethyl)pyridin-2-amine;

6-chloro-N-(pyrrolidin-3-ylmethyl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-(2,3-dimethylbenzyl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-(pyridin-4-ylmethyl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(tetrahydro-2H-pyran-2-ylmethyl)pyridin-2-amine;

6-chloro-N-piperidin-4-yl-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-(4-methoxycyclohexyl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)acetamide;

6-chloro-N-(4-chloro-2-fluorobenzyl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-{[2-(pyridin-3-yloxy)pyridin-3-yl]methyl}-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-(piperidin-3-ylmethyl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

1-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}propan-2-ol;

2-(2-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}ethoxy)ethanol;

3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}-2,2-dimethylpropan-1-ol;

6-chloro-N-[1-(methylsulfonyl)piperidin-4-yl]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

N-(4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)benzenesulfonamide;

N-(4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-1-phenylmethanesulfonamide;

N-(4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)pyridine-3-sulfonamide;

N-(4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)propane-1-sulfonamide;

6-chloro-N-[2-(morpholin-4-yl)ethyl]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

3-(2-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}ethyl)phenol;

N-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]-N′-(2-methylpropyl)cyclohexane-1,3-diamine;

N′-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]-N,N-dimethylcyclohexane-1,3-diamine;

1-(4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-3-cyclopentylurea;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)cyclopropanesulfonamide;

1-(4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-3-propylurea;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)cyclopropanecarboxamide;

N-(4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-2-methylpropanamide;

N-(4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)benzamide;

1-(4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-3-phenylurea;

N-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]-N′-(pyridin-3-ylmethyl)cyclohexane-1,3-diamine;

N-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]-N′-cyclobutylcyclohexane-1,3-diamine;

N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)cyclopropanecarboxamide;

N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-1-propylpiperidine-4-carboxamide;

N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-1H-pyrazole-3-carboxamide;

N-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]-N′-(piperidin-3-ylmethyl)cyclohexane-1,3-diamine;

N-{2-[(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)amino]-2-oxoethyl}benzamide;

N-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]-2,2-dimethylpropane-1,3-diamine;

N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}-2,2-dimethylpropyl)methanesulfonamide;

N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)cyclopropanesulfonamide;

N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)propane-1-sulfonamide;

N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-4-methylbenzenesulfonamide;

1-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-3-ethylurea;

1-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-3-cyclopentylurea;

N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}-2,2-dimethylpropyl)pyridine-3-sulfonamide;

N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}-2,2-dimethylpropyl)cyclopropanesulfonamide;

N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)thiophene-2-sulfonamide;

N-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]pentanamide;

N-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]cyclohexanecarboxamide;

N-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]benzamide;

N-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]ethane-1,2-diamine;

N-(2-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}ethyl)methanesulfonamide;

N-(2-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}ethyl)cyclopropanesulfonamide;

N-(2-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}ethyl)pyridine-3-sulfonamide;

6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-cyclobutyl-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

trans-N′-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]-N,N-dimethylcyclohexane-1,4-diamine;

6-chloro-N-[(1-ethylpiperidin-3-yl)methyl]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-[(1-cyclobutylpiperidin-3-yl)methyl]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-{[1-(pyridin-3-ylmethyl)piperidin-3-yl]methyl}-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-{[1-(methylsulfonyl)piperidin-3-yl]methyl}-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

3-({[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}methyl)-N-ethylpiperidine-1-carboxamide;

1-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-3-methylurea;

1-[3-({[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}methyl)piperidin-1-yl]ethanone;

6-chloro-N-{[1-(cyclopropylsulfonyl)piperidin-3-yl]methyl}-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}piperidin-1-yl)(cyclopropyl)methanone;

N-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]-N′-(cyclopropylmethyl)cyclohexane-1,3-diamine;

6-chloro-N-(1-cyclobutylpiperidin-3-yl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

trans-N-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]-N′-cyclobutylcyclohexane-1,4-diamine;

(2S)—N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)azetidine-2-carboxamide;

N-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]pyridine-3-carboxamide;

N-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]butanamide;

trans-N-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]-N′-(cyclopropylmethyl)cyclohexane-1,4-diamine;

N-[(trans)-2-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl]methanesulfonamide;

N-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]-2,6-difluorobenzamide;

N-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]piperidine-4-carboxamide;

N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}-2,2-dimethylpropyl)acetamide;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-N 2 ,N 2 -dimethylglycinamide;

(2S)—N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-4-oxoazetidine-2-carboxamide;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-N 2 -methyl-L-alaninamide;

azetidin-2-yl(4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}piperidin-1-yl)methanone;

N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-N 2 ,N 2 -dimethylglycinamide;

N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-1-methyl-L-prolinamide;

N-[(trans)-2-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl]azetidine-2-carboxamide;

N′-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]-N,N,2,2-tetramethylpropane-1,3-diamine;

N-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]methanesulfonamide;

N-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]benzenesulfonamide;

N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}-2,2-dimethylpropyl)cyclopropanecarboxamide;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-1-methylpyrrolidine-3-carboxamide;

(4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}piperidin-1-yl)(cyclopropyl)methanone;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-N 2 ,N 2 -dimethyl-L-alaninamide;

6-chloro-N-(1-cyclobutylpiperidin-4-yl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)piperidine-2-carboxamide;

N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-2-(pyrrolidin-1-yl)acetamide;

(cis)-N-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]cyclohexane-1,2-diamine;

N-[(cis)-2-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl]methane sulfonamide;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)cyclobutanecarboxamide;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-1-ethylazetidine-2-carboxamide;

1-amino-N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)cyclobutanecarboxamide;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-1-cyclopentylazetidine-2-carboxamide;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-N 2 -cyclopentylglycinamide;

6-chloro-N-[1-(methylsulfonyl)piperidin-3-yl]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-5-oxoprolinamide;

(cis)-N′-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]-N,N-dimethylcyclohexane-1,2-diamine;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-2-(morpholin-4-yl)acetamide;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-2-[4-(pyridin-2-yl)piperazin-1-yl]acetamide;

N-{4-[(4-aminocyclohexyl)methyl]cyclohexyl}-6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-2,6-dioxopiperidine-4-carboxamide;

2-amino-N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)ethanesulfonamide;

6-chloro-N-[(1-methylpiperidin-3-yl)methyl]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

1-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}piperidin-1-yl)ethanone;

trans-N-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]-N′-(1-methylpiperidin-4-yl)cyclohexane-1,4-diamine;

trans-4-{[6-chloro-4-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexanol;

N-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]-2-(morpholin-4-yl)acetamide;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)pyrrolidine-3-sulfonamide;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-N 2 -(trans-4-hydroxycyclohexyl)glycinamide;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-N 2 -[2-(morpholin-4-yl)ethyl]glycinamide;

N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-2-(dimethylamino)ethanesulfonamide;

6-chloro-N-(4-{[4-(dimethylamino)cyclohexyl]methyl}cyclohexyl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-(4-{[4-(cyclohexylamino)cyclohexyl]methyl}cyclohexyl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

trans-N-[6-chloro-4-(1H-pyrrolo[2,3-b] pyridin- 3-yl)pyridin-2-yl]-N′-(1-cyclohexylpiperidin-4-yl)cyclohexane-1,4-diamine;

trans-N-(4-aminocyclohexyl)-N′-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]cyclohexane-1,4-diamine;

6-chloro-N-[4-(piperidin-4-yl)cyclohexyl]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)azetidine-3-carboxamide;

N-{4-[(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)amino]cyclohexyl}acetamide;

N-{4-[(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)amino]cyclohexyl}cyclopropanecarboxamide;

1-[4-(4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)piperidin-1-yl]ethanone;

N-{2-[(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)sulfamoyl]ethyl}acetamide;

N-{2-[(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)sulfamoyl]ethyl}cyclopropanecarboxamide;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-1-(4-fluorobenzyl)azetidine-3-carboxamide;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-1-(methylsulfonyl)azetidine-3-carboxamide;

6-chloro-4-(4-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-cyclohexylpyridin-2-amine;

N-{2-[(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)sulfamoyl]ethyl}benzamide;

N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-2-(cyclobutylamino)ethanesulfonamide;

6-chloro-N-cyclohexyl-4-[5-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyridin-2-amine;

N-{2-[(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)sulfamoyl]ethyl}pyrazine-2-carboxamide;

4-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-6-chloro-N-cyclohexylpyridin-2-amine;

N-{4-[(4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)methyl]cyclohexyl}acetamide;

{4-[(4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)amino]piperidin-1-yl}(cyclopropyl)methanone;

6-chloro-N-cyclohexyl-4-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyridin-2-amine;

{4-[(4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)amino]piperidin-1-yl}(phenyl)methanone;

6-chloro-N-cyclohexyl-4-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

2-amino-N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)ethanesulfonamide;

3-[2-chloro-6-(cyclohexylamino)pyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-5-ol;

6-chloro-N-[4-(piperidin-3-yl)cyclohexyl]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-[4-(1-cyclobutylpiperidin-4-yl)cyclohexyl]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-{4-[1-(methylsulfonyl)piperidin-4-yl]cyclohexyl}-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-[4-(1-methylpiperidin-4-yl)cyclohexyl]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-methyl-N-[4-(1-methylpiperidin-4-yl)cyclohexyl]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-{4-[1-(methylsulfonyl)piperidin-3-yl]cyclohexyl}-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-cyclohexyl-4-(5-{1-[2-(morpholin-4-yl)ethyl]-1H-pyrazol-4-yl}-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

[3-(4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)piperidin-1-yl](cyclopropyl)methanone;

6-chloro-N-[4-(1-cyclobutylpiperidin-3-yl)cyclohexyl]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-[4-(pyrrolidin-3-yl)cyclohexyl]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

N-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]-1′-methyl-1,4′-bipiperidin-4-amine;

4-(4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)piperazin-2-one;

N-{2-[(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)sulfamoyl]ethyl}benzamide;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-2-[(methylsulfonyl)amino]ethanesulfonamide;

6-chloro-N-cyclohexyl-4-{5-[2-(morpholin-4-yl)ethoxy]-1H-pyrrolo[2,3-b]pyridin-3-yl}pyridin-2-amine;

6-chloro-N-cyclohexyl-4-{5-[(1-methyl-1H-imidazol-5-yl)methoxy]-1H-pyrrolo[2,3-b]pyridin-3-yl}pyridin-2-amine;

6-chloro-N-[4-(1-methylpyrrolidin-3-yl)cyclohexyl]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-{4-[1-(4-fluorobenzyl)pyrrolidin-3-yl]cyclohexyl}-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-{4-[1-(methylsulfonyl)pyrrolidin-3-yl]cyclohexyl}-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-{1-[4-(cyclobutylamino)cyclohexyl]piperidin-4-yl}-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

3-[2-chloro-6-(cyclohexylamino)pyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-2,4-difluorobenzamide;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-4-(trifluoromethoxy)benzamide;

6-chloro-N-cyclohexyl-4-(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-phenyl-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

1-(4-chlorobenzyl)-N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)azetidine-3-carboxamide;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-2-[(prop-2-en-1-ylcarbamoyl)amino]ethanesulfonamide;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-1-(pyridin-3-ylmethyl)azetidine-3-carboxamide;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-1-(2,4-difluorobenzyl)azetidine-3-carboxamide;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-1-[(1-methyl-1H-pyrazol-3-yl)methyl]azetidine-3-carboxamide;

2-(4-{3-[2-chloro-6-(cyclohexylamino)pyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-1H-pyrazol-1-yl)ethanol;

trans-N-[6-chloro-4-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]cyclohexane-1,4-diamine;

6-chloro-N-cyclohexyl-4-[5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyridin-2-amine;

6-chloro-N-cyclohexyl-4-[5-(thiophen-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyridin-2-amine;

N-(trans-4-{[6-chloro-4-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)cyclopropanecarboxamide;

1-benzyl-N-(trans-4-{[6-chloro-4-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)azetidine-3-carboxamide;

N-(trans-4-{[6-chloro-4-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)cyclopropanesulfonamide;

N-(trans-4-{[6-chloro-4-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-1-ethylpyrrolidine-3-carboxamide;

N-(trans-4-{[6-chloro-4-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)methanesulfonamide;

6-chloro-N-cyclohexyl-4-(5-{3-[(4-methylpiperazin-1-yl)methyl]phenyl}-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

3-{3-[2-chloro-6-(cyclohexylamino)pyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-5-yl}benzenesulfonamide;

4-{3-[2-chloro-6-(cyclohexylamino)pyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-5-yl}benzenesulfonamide;

trans-N-[6-chloro-4-(5-ethoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]cyclohexane-1,4-diamine;

3-[2-chloro-6-(cyclohexylamino)pyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-5-amine;

N-{3-[2-chloro-6-(cyclohexylamino)pyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-5-yl}acetamide;

N-(trans-4-{[6-chloro-4-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-N 2 -methylglycinamide;

N-(trans-4-{[6-chloro-4-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-2-methylpropanamide;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-2-[4-(4-fluorophenyl)piperazin-1-yl]acetamide;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-2-[4-(pyridin-4-yl)piperazin-1-yl]acetamide;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-2-(4-cyclohexylpiperazin-1-yl)acetamide;

2-(4-butylpiperazin-1-yl)-N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)acetamide;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-2-[4-(furan-2-ylcarbonyl)piperazin-1-yl]acetamide;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-2-[4-(2-cyanophenyl)piperazin-1-yl]acetamide;

3-[2-chloro-6-(cyclohexylamino)pyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid;

6-chloro-4-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-[4-(piperidin-4-yl)cyclohexyl]pyridin-2-amine;

N-{4-[(4-aminocyclohexyl)methyl]cyclohexyl}-6-chloro-4-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-(4-{[4-(cyclohexylamino)cyclohexyl]methyl}cyclohexyl)-4-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

3-[2-chloro-6-(cyclohexylamino)pyridin-4-yl]-N-phenyl-1H-pyrrolo[2,3-b]pyridin-5-amine;

N-{4-[(4-{[6-chloro-4-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)methyl]cyclohexyl}cyclopropanecarboxamide;

trans-N-{6-chloro-4-[5-(prop-2-yn-1-yloxy)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyridin-2-yl}cyclohexane-1,4-diamine;

3-[2-chloro-6-(cyclohexylamino)pyridin-4-yl]-N-(pyridin-2-ylmethyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide;

6-chloro-N-cyclohexyl-4-[5-(pyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyridin-2-amine;

N-(trans-4-{[6-chloro-4-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)butane-1-sulfonamide;

4-[5-(6-aminopyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-6-chloro-N-cyclohexylpyridin-2-amine;

N-(trans-4-{[6-chloro-4-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)glycinamide;

6-chloro-N-cyclohexyl-4-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

1-{3-[2-chloro-6-(cyclohexylamino)pyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-3-ethylurea;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-1-(pyridin-4-ylmethyl)azetidine-3-carboxamide;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-1-(piperidin-4-yl)azetidine-3-carboxamide;

N-(trans-4-{[6-chloro-4-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-N 2 -cyclohexylglycinamide;

6-chloro-N-[4-(1-cyclobutylpiperidin-4-yl)cyclohexyl]-4-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

N-(trans-4-{[6-chloro-4-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)cyclohexanesulfonamide;

N-(trans-4-{[6-chloro-4-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-2-(morpholin-4-yl)acetamide;

N-(3-{3-[2-chloro-6-(cyclohexylamino)pyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-5-yl}phenyl)acetamide;

N-{3-[2-chloro-6-(cyclohexylamino)pyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-5-yl}methanesulfonamide;

N-{4-[(4-{[6-chloro-4-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)methyl]cyclohexyl}pyridine-3-carboxamide;

N-(trans-4-{[6-chloro-4-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-N 2 -(2,2-dimethylpropyl)glycinamide;

6-chloro-N-(4-{[4-(dimethylamino)cyclohexyl]methyl}cyclohexyl)-4-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

N-(3-{[6-chloro-4-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)cyclopropanesulfonamide;

N-(3-{[6-chloro-4-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)acetamide;

N-(3-{[6-chloro-4-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)thiophene-2-sulfonamide;

N-(3-{[6-chloro-4-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-2-(pyrrolidin-1-yl)acetamide;

N-(4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-3,5-dimethyl-1,2-oxazole-4-sulfonamide;

6-chloro-N-[(2S)-1-methoxy-3-phenylpropan-2-yl]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

N-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]-N′-cyclopentylcyclohexane-1,3-diamine;

ethyl N-[(4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)carbamoyl]glycinate;

1-(4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-3-propan-2-ylurea;

1-tert-butyl-3-(4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)urea;

N-(4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-2-methoxyacetamide;

N-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]-N′-(1,3-thiazol-2-ylmethyl)cyclohexane-1,3-diamine;

N-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]-N′-[3-(piperidin-1-ylmethyl)benzyl]cyclohexane-1,3-diamine;

N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-2-ethoxyacetamide;

N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-2-phenoxyacetamide;

N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)pyrazine-2-carboxamide;

N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)azetidine-2-carboxamide;

tert-butyl 2-[(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)carbamoyl]azetidine-1-carboxylate;

1-(4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-3-prop-2-en-1-ylurea;

N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}-2,2-dimethylpropyl)-1-methyl-1H-imidazole-4-sulfonamide;

N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)furan-2-sulfonamide;

N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)pyridine-3-sulfonamide;

1-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-3-propan-2-ylurea;

ethyl N-[(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)carbamoyl]glycinate;

1-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-3-(cyclohexylmethyl)urea;

4-acetyl-N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}-2,2-dimethylpropyl)benzenesulfonamide;

N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}-2,2-dimethylpropyl)-3,5-dimethyl-1,2-oxazole-4-sulfonamide;

N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}-2,2-dimethylpropyl)thiophene-2-sulfonamide;

N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-3,5-dimethyl-1,2-oxazole-4-sulfonamide;

1-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-3-propylurea;

N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}-2,2-dimethylpropyl)propane-1-sulfonamide;

N-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]acetamide;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)propane-2-sulfonamide;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)ethanesulfonamide;

N-(2-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}ethyl)butane-1-sulfonamide;

N-(2-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}ethyl)thiophene-2-sulfonamide;

6-chloro-N-(1-methylpiperidin-3-yl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

[3-({[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}methyl)piperidin-1-yl](cyclopropyl)methanone;

N-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]-N-{[1-(cyclopropylcarbonyl)piperidin-3-yl]methyl}cyclopropanecarboxamide;

6-chloro-N-{[1-(cyclopropylmethyl)piperidin-3-yl]methyl}-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-[1-(cyclopropylmethyl)piperidin-3-yl]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

N-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]-2-(1H-indol-2-yl)acetamide;

trans-N-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]-N′-cyclopentylcyclohexane-1,4-diamine;

trans-N-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]-N′-(2-methylpropyl)cyclohexane-1,4-diamine;

6-chloro-N-[3-(pyrrolidin-1-yl)cyclohexyl]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-[3-(piperidin-1-yl)cyclohexyl]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-N 2 -methylglycinamide;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-1-ethylpyrrolidine-3-carboxamide;

N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-N 2 -methylalaninamide;

(2R)—N-[(1S,3S)-3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl]-2-(methylamino)-2-phenylethanamine;

(2R)—N-[(1R,3R)-3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl]-2-(methylamino)-2-phenylethanamine;

N-[(1R,2R)-2-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl]cyclopropanesulfonamide;

N-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]-4-fluorobenzenesulfonamide;

N-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]cyclopropanesulfonamide;

N′-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]-N,N-diethyl-2,2-dimethylpropane-1,3-diamine;

trans-N′-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]-N,N-diethylcyclohexane-1,4-diamine;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-5-oxo-D-prolinamide;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-1-methylprolinamide;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-1-methylpiperidine-2-carboxamide;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-5-oxo-L-prolinamide;

N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-1-methylpiperidine-2-carboxamide;

2-(azepan-1-yl)-N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)acetamide;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)cyclopentanecarboxamide;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-1-methyl-5-oxoprolinamide;

N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)pyrrolidine-3-carboxamide;

N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)piperidine-4-carboxamide;

N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)piperidine-3-carboxamide;

N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-1-methylpyrrolidine-3-carboxamide;

N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-1-methylpiperidine-4-carboxamide;

N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-1-methylpiperidine-3-carboxamide;

N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-1-(dimethylamino)cyclobutanecarboxamide;

N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-N 2 ,N 2 -dimethyl-L-alaninamide;

N 2 -1-azabicyclo[2.2.2]oct-3-yl-N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)glycinamide;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-N 2 -(2-hydroxyethyl)glycinamide;

N-(3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethanesulfonamide;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-N 2 -(4-methylcyclohexyl)glycinamide;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-N 2 -(2,2-dimethylpropyl)glycinamide;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-N 2 -ethyl-N 2 -(2-hydroxyethyl)glycinamide;

trans-N-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]-N′-(piperidin-4-yl)cyclohexane-1,4-diamine;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethanesulfonamide;

6-chloro-N-(4-{[4-(cyclobutylamino)cyclohexyl]methyl}cyclohexyl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

trans-N-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]-N′-(1-cyclobutylpiperidin-4-yl)cyclohexane-1,4-diamine;

tert-butyl 4-(4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)piperidine-1-carboxylate;

benzyl {4-[(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)amino]cyclohexyl}carbamate;

tert-butyl 3-[(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)carbamoyl]azetidine-1-carboxylate;

N-[4-(acetylamino)cyclohexyl]-N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)acetamide;

[4-(4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)piperidin-1-yl] (cyclopropyl)methanone;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-1-(2-hydroxyethyl)piperidine-4-carboxamide;

N-{4-[(4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)methyl]cyclohexyl}cyclopropanecarboxamide;

1-{4-[(4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)amino]piperidin-1-yl}ethanone;

N-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]-N-{4-[1-(methylsulfonyl)piperidin-4-yl]cyclohexyl}methanesulfonamide;

6-chloro-N-[4-(1-methylpiperidin-3-yl)cyclohexyl]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-methyl-N-[4-(1-methylpiperidin-3-yl)cyclohexyl]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

N-{2-[(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)sulfamoyl]ethyl}cyclopropanecarboxamide;

3-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}propan-1-ol;

6-chloro-N-[3-(morpholin-4-yl)propyl]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-[3-(1H-imidazol-1-yl)propyl]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

5-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}pentan-1-ol;

6-chloro-N-[2-(pyridin-3-yl)ethyl]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

N-[1-(4-aminocyclohexyl)piperidin-4-yl]-6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-methyl-N-[4-(1-methylpyrrolidin-3-yl)cyclohexyl]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

1-benzyl-N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)azetidine-3-carboxamide;

4-chloro-N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-2-methoxybenzamide;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-3-(trifluoromethyl)benzamide;

3-chloro-N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)benzamide;

6-chloro-N-[2-(3,4-dimethoxyphenyl)ethyl]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-[2-(pyridin-2-yl)ethyl]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-(2-phenylethyl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-[3-(4-methylpiperazin-1-yl)propyl]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-(2-phenoxyethyl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

N′-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]-N,N-dimethylpropane-1,3-diamine;

N-(1-benzylpyrrolidin-3-yl)-6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

N-{2-[(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)sulfamoyl]ethyl}-2,4-difluorobenzamide;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-1-[3-(trifluoromethyl)benzyl]azetidine-3-carboxamide;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-1-(2,4-dichlorobenzyl)azetidine-3-carboxamide;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-1-(1-phenylethyl)azetidine-3-carboxamide;

6-chloro-N-(4-methoxybenzyl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

4-(2-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}ethyl)phenol;

N-[2-(1,3-benzodioxol-5-yl)ethyl]-6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

N-(1,3-benzodioxol-5-ylmethyl)-6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-[2-(4-methoxyphenyl)ethyl]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

N-(1-benzylpiperidin-4-yl)-6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-[2-(pyridin-4-yl)ethyl]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-(2,3-dihydro-1H-inden-2-yl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-[2-(1H-indol-3-yl)ethyl]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-1-(2,3-dimethylbenzyl)azetidine-3-carboxamide;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-1-(1H-indol-6-ylmethyl)azetidine-3-carboxamide;

N-[4-(benzyloxy)phenyl]-6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

N-(1H-benzimidazol-2-ylmethyl)-6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-(1H-indol-5-ylmethyl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-(4-methoxyphenyl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(3,4,5-trimethoxyphenyl)pyridin-2-amine;

6-chloro-N-[4-(1H-imidazol-1-yl)phenyl]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-(3,4-dimethoxybenzyl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

2-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}-1-phenylethanol;

6-chloro-N-(3-phenylpropyl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-[4-(methylsulfonyl)benzyl]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-[4-(methylsulfanyl)phenyl]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-(4-phenoxyphenyl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-[4-(piperidin-1-yl)phenyl]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

methyl 3-[2-chloro-6-(cyclohexylamino)pyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine-5-carboxylate;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-2-[4-(2-hydroxyethyl)piperazin-1-yl]acetamide;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-2-[4-(2,6-dimethylphenyl)piperazin-1-yl]acetamide;

6-chloro-N-(4-{[4-(cyclobutylamino)cyclohexyl]methyl}cyclohexyl)-4-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-4-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(4-{[4-(pentan-3-ylamino)cyclohexyl]methyl}cyclohexyl)pyridin-2-amine;

6-chloro-N-[4-({4-[(cyclopentylmethyl)amino]cyclohexyl}methyl)cyclohexyl]-4-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

trans-N-(6-chloro-4-{5-[2-(pyridin-2-yl)ethoxy]-1H-pyrrolo[2,3-b]pyridin-3-yl}pyridin-2-yl)cyclohexane-1,4-diamine;

trans-N-{6-chloro-4-[5-(2-methylpropoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyridin-2-yl}cyclohexane-1,4-diamine;

N-(trans-4-{[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-1-(pyridin-2-ylmethyl)azetidine-3-carboxamide;

N-(trans-4-{[6-chloro-4-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-2,2,2-trifluoroacetamide;

6-chloro-N-cyclohexyl-4-[5-(6-methoxypyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyridin-2-amine;

N-(trans-4-{[6-chloro-4-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-N 2 -ethyl-N 2 -(2-hydroxyethyl)glycinamide;

N-(trans-4-{[6-chloro-4-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-N 2 -(2-hydroxyethyl)glycinamide;

N′-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]-N,N-dimethylbenzene-1,4-diamine;

6-chloro-N-(2,3-dihydro-1H-inden-5-yl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-{4-[1-(2,4-difluorobenzyl)piperidin-4-yl]cyclohexyl}-4-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-[4-(morpholin-4-yl)phenyl]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(5,6,7,8-tetrahydronaphthalen-1-yl)pyridin-2-amine;

N-(4-tert-butylphenyl)-6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-(2,3-dihydro-1H-inden-4-yl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

N-[6-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]quinolin-6-amine;

6-chloro-N-[4-(4-methylpiperazin-1-yl)phenyl]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-[4-(1,1-dioxidothiomorpholin-4-yl)phenyl]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

N-(trans-4-{[6-chloro-4-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-N 2 -(trans-4-hydroxycyclohexyl)glycinamide;

N-(trans-4-{[6-chloro-4-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-N 2 -propan-2-ylglycinamide;

N-{4-[(4-{[6-chloro-4-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)methyl]cyclohexyl}-3,5-dimethyl-1,2-oxazole-4-sulfonamide;

N-(3-{[6-chloro-4-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl]amino}cyclohexyl)-N 2 ,N 2 -dimethylglycinamide;

6-chloro-N-{4-[4-(pyridin-2-ylmethyl)piperazin-1-yl]phenyl}-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-{4-[4-(cyclohexylmethyl)piperazin-1-yl]phenyl}-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

6-chloro-N-{4-[4-(2-methylpropyl)piperazin-1-yl]phenyl}-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine;

N-[trans-4({4-[5-(6-aminopyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-6-chloropyridin-2-yl}amino)cyclohexyl]cyclopropanesulfonamide;

N-[trans-4-({6-chloro-4-[5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyridin-2-yl}amino)cyclohexyl]cyclopropanesulfonamide;

3-{3-[2-chloro-6-({trans-4-[(cyclopropylsulfonyl)amino]cyclohexyl}amino)pyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-5-yl}benzenesulfonamide; and

N-[trans-4-({6-chloro-4-[5-(pyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyridin-2-yl}amino)cyclohexyl]cyclopropanesulfonamide.

15. A pharmaceutical composition comprising a compound or pharmaceutically acceptable salt of claim 1 and pharmaceutically acceptable excipient.