Targeted drug delivery device and method
View Patent ↗A targeted drug delivery device is provided. The device comprises an elongated member with proximal and distal ends, a plurality of infusion ports associated with the distal end of the elongated member, and a selector mechanism for selectively placing an introducer port into fluid communication with at least one infusion port. A method for treating tissue is also provided. The method comprises introducing a medical device into the tissue, selecting a region of the tissue to treat, positioning the medical device in proximity to the region, and introducing a medicament through the device to treat only that region.
1. A method of treating a lesion located remotely in tissue, comprising:
introducing a medical device comprising a plurality of ports into the tissue adjacent the lesion;
selecting a region of the lesion to treat;
selecting a port in proximity to the region;
introducing a medicament through the selected port, whereby the application of the medicament is focused in the selected lesion region;
selecting another region of the lesion to treat;
selecting another port in proximity to the second region; and
introducing a medicament through the second port, whereby the application of the medicament is focused in the other selected lesion region.
2. The method of claim 1 , wherein the medicament is a chemotherapeutic agent.
3. The method of claim 1 , wherein the lesion is a tumor.
4. The method of claim 1 , wherein the tissue is brain tissue.
5. The method of claim 1 , wherein the medicament introduced in the lesion region and the medicament introduced in the other region are different from each other.
6. The method of claim 1 , wherein the medicament is delivered via forced convection.
7. The method of claim 1 , wherein the medicament is introduced within an interstitial space formed by removing a tumor.
8. A method of treating an interstitial space located remotely in tissue, comprising:
providing a delivery device, the delivery device comprising:
an elongated tubular member having a proximal end, a distal end, and a plurality of lumens extending from the proximal end to the distal end;
an introduction port in fluid communication with the plurality of lumens;
a selector mechanism configured for selectively placing the introduction port in fluid communication with a lumen selected from the plurality of lumens; and
an inflatable balloon disposed adjacent the distal end of the elongated tubular member, the balloon including a plurality of ports, wherein the plurality of lumens are in fluid communication with the plurality of ports;
introducing the delivery device into the tissue adjacent the interstitial space;
adjusting the selector mechanism to place the introduction port in fluid communication with a selected lumen;
delivering a medicament through the selected lumen; and
inflating the inflatable balloon, wherein a size of the plurality of ports increase as the balloon is inflated.
9. The method of claim 8 , further comprising selecting a region of the interstitial space to be treated.
10. The method of claim 9 , further comprising rotating the delivery device to align with the selected region.
11. The method of claim 8 , wherein the balloon is inflated to control the size of the ports.
12. The method of claim 8 , wherein the medicament is delivered via forced convection.
13. A method of treating an interstitial space located remotely in tissue, comprising:
providing a delivery device, the delivery device comprising:
an elongated tubular member having a proximal end, a distal end, and a plurality of lumens extending from the proximal end to the distal end;
an introduction port in fluid communication with the plurality of lumens; and
a selector mechanism configured for selectively placing the introduction port in fluid communication with a lumen selected from the plurality of lumens;
introducing the delivery device into the tissue adjacent the interstitial space;
adjusting the selector mechanism to place the introduction port in fluid communication with a first selected lumen;
introducing a medicament through the first selected lumen;
flushing the introduction port with a biologically inactive fluid;
adjusting the selector mechanism to place the introduction port in fluid communication with a second selected lumen, the second selected lumen different from the first selected lumen; and
introducing a medicament through the second selected lumen.
14. The method of claim 13 , wherein the medicament introduced in the first lumen and the medicament introduced in the second lumen are different from each other.
15. The method of claim 13 , wherein the medicament introduced in the first lumen and the medicament introduced in the second lumen are introduced to different regions of the interstitial space.