Treatment of CNS disorders with trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine
Treatment of CNS disorders with (1R,4S)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine; and (1S,4R)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine is disclosed. A process for preparing 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine is also disclosed. The process includes the preparation of all four isomers of N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]formamide, which are also useful.
1. A method for treating cerebral function disorders involving intellectual deficits, the method comprising administering to a person in need of treatment for cerebral function disorders involving intellectual deficits a therapeutically effective amount of a compound of formula PQ:
or a salt thereof
2. A method according to claim 1 , wherein the compound of formula PQ is selected from formula P or Q:
or a salt thereof
3. A method according to claim 1 , wherein the compound of formula PQ is (1S,4R)-N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine or a salt thereof.
4. A method according to claim 1 , wherein the compound of formula PQ is (1R,4S)-N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine or a salt thereof.
5. A method according to claim 1 , wherein the compound of formula PQ is (1S,4R)-N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine hydrochloride.
6. A method according to claim 1 , wherein the compound of formula PQ is (1R,4S)-N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine hydrochloride.
7. A method for treating cerebral function disorders associated with schizophrenia, the method comprising administering to a person in need of treatment for cerebral function disorders associated with schizophrenia a therapeutically effective amount of a compound of formula PQ:
or a salt thereof.
8. A method according to claim 7 , wherein the compound of formula PQ is selected from formula P or Q:
or a salt thereof.
9. A method according to claim 7 , wherein the compound of formula PQ is (1S,4R)-N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine or a salt thereof.
10. A method according to claim 7 , wherein the compound of formula PQ is (1R,4S)-N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine or a salt thereof.
11. A method according to claim 7 , wherein the compound of formula PQ is (1S,4R)-N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine hydrochloride.
12. A method according to claim 7 , wherein the compound of formula PQ is (1R,4S)-N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine hydrochloride.
13. A method for treating intellectual deficits associated with schizophrenia, the method comprising administering to a person in need of treatment for intellectual deficits associated with schizophrenia a therapeutically effective amount of a compound of formula PQ:
or a salt thereof.
14. A method according to claim 13 , wherein the compound of formula PQ is selected from formula P or Q:
or a salt thereof.
15. A method according to claim 13 , wherein the compound of formula PQ is (1S,4R)-N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine or a salt thereof.
16. A method according to claim 13 , wherein the compound of formula PQ is (1R,4S)-N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine or a salt thereof.
17. A method according to claim 13 , wherein the compound of formula PQ is (1S,4R)-N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine hydrochloride.
18. A method according to claim 13 , wherein the compound of formula PQ is (1R,4S)-N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine hydrochloride.