Antimicrobial hydrochloric acid catheter lock solution and method of use
View Patent ↗A catheter lock solution includes a hydrochloric acid solution having a concentration of 0.3 Molar to 1.0 Molar. This hydrochloric acid solution may be used to lock a catheter and/or salvage an infected catheter.
1. A catheter lock solution in a catheter, the catheter lock solution comprising:
a hydrochloric acid solution having a concentration of 0.3 Molar to 1.0 Molar; and
an antimicrobial agent including 5-Fluorouracil, wherein the 5-Fluorouracil is eluted from the catheter and configured to provide a concentration of 8 ppm to 256 ppm of the 5-Fluorouracil adjacent to a surface of the catheter.
2. The catheter lock solution in a catheter according to claim 1 , wherein the hydrochloric acid solution includes a hydrochloric acid concentration of 0.3 Molar to 0.5 Molar.
3. The catheter lock solution in a catheter according to claim 1 , wherein the antimicrobial agent includes silver sulfadiazine.
4. The catheter lock solution in a catheter according to claim 3 , wherein the silver sulfadiazine is eluted from the catheter and configured to provide a concentration of at least 128 parts per million (ppm) of the silver sulfadiazine adjacent to a surface of the catheter.
5. The catheter lock solution in a catheter according to claim 1 , wherein the antimicrobial agent includes Rifampin and Minocycline.
6. The catheter lock solution in a catheter according to claim 1 , further comprising:
an anti-coagulant.
7. The catheter lock solution in a catheter according to claim 6 , wherein the anti-coagulant is heparin.
8. A catheter salvage solution in a catheter, the catheter salvage solution comprising:
a hydrochloric acid solution having a concentration of 0.3 Molar to 1.0 Molar; and
an antimicrobial agent including 5-Fluorouracil, wherein the 5-Fluorouracil is eluted from the catheter and configured to provide a concentration of 8 ppm to 256 ppm of the 5-Fluorouracil adjacent to a surface of the catheter.
9. The catheter salvage solution according to claim 8 , wherein the hydrochloric acid solution includes a hydrochloric acid concentration of 0.3 Molar to 0.5 Molar.
10. The catheter salvage solution in a catheter according to claim 8 , wherein the antimicrobial agent includes silver sulfadiazine.
11. The catheter salvage solution in a catheter according to claim 10 , wherein the silver sulfadiazine is eluted from the catheter and configured to provide a concentration of at least 128 ppm of the silver sulfadiazine adjacent to a surface of the catheter.
12. The catheter salvage solution in a catheter according to claim 8 , wherein the antimicrobial agent includes Rifampin and Minocycline.
13. The catheter salvage solution in a catheter according to claim 8 , further comprising:
an anti-coagulant.
14. The catheter salvage solution in a catheter according to claim 13 , wherein the anti-coagulant is heparin.
15. A method of inhibiting microbial contamination in a catheter, the method comprising the step of:
infusing a lumen of the catheter with a hydrochloric acid solution having a concentration of 0.3 Molar to 1.0 Molar,
wherein the hydrochloric acid solution further includes an antimicrobial agent,
wherein the antimicrobial agent includes 5-fluorouracil, and
wherein the 5-fluorouracil is eluted from the catheter and configured to provide a concentration of 8 ppm to 256 ppm of the 5-fluorouracil adjacent to the surface of the catheter.
16. The method according to claim 15 , further comprising the step of:
allowing the hydrochloric acid solution to dwell within the lumen for about an hour.
17. The method according to claim 16 , further comprising the step of:
drawing the hydrochloric acid solution from the lumen following the hour dwell time.
18. The method according to claim 17 , further comprising the step of:
flushing the catheter with a saline solution following the withdrawal of the hydrochloric acid solution.
19. The method according to claim 15 , wherein the hydrochloric acid solution includes a hydrochloric acid concentration of 0.3 Molar to 0.5 Molar.
20. The method according to claim 15 , wherein the antimicrobial agent includes silver sulfadiazine.
21. The method according to claim 20 , wherein the silver sulfadiazine is eluted from the catheter and configured to provide a concentration of at least 128 ppm of the silver sulfadiazine adjacent to a surface of the catheter.
22. The method according to claim 15 , wherein the antimicrobial agent includes Rifampin and Minocycline.
23. The method according to claim 15 , further comprising:
an anti-coagulant.
24. The method according to claim 23 , wherein the anti-coagulant is heparin.
25. A method of treating a patient having a microbial contamination of an indwelling catheter, the method comprising the steps of:
infusing a lumen of the catheter with a hydrochloric acid solution having a concentration of 0.3 Molar to 1.0 Molar,
wherein the hydrochloric acid solution further includes an antimicrobial agent,
wherein the antimicrobial agent includes 5-fluorouracil, and
wherein the 5-fluorouracil is eluted from the catheter and configured to provide a concentration of 8 ppm to 256 ppm of the 5-fluorouracil adjacent to the surface of the catheter.
26. The method according to claim 25 , further comprising the step of:
allowing the hydrochloric acid solution to dwell within the lumen for about 30 minutes.
27. The method according to claim 26 , further comprising the step of:
drawing the hydrochloric acid solution from the lumen following the hour dwell time.
28. The method according to claim 27 , further comprising the step of:
flushing the catheter with a saline solution following the withdrawal of the hydrochloric acid solution.
29. The method according to claim 25 , wherein the hydrochloric acid solution includes a hydrochloric acid concentration of 0.3 Molar to 0.5 Molar.
30. The method according to claim 25 , further comprising the step of:
selecting a hydrochloric acid concentration of 0.4 Molar to 1.0 Molar in response to a biofilm of microbial contamination being present in the catheter.
31. The method according to claim 25 , wherein the antimicrobial agent includes silver sulfadiazine.
32. The method according to claim 31 , wherein the silver sulfadiazine is eluted from the catheter and configured to provide a concentration of at least 128 ppm of the silver sulfadiazine adjacent to a surface of the catheter.
33. The method according to claim 25 , wherein the antimicrobial agent includes Rifampin and Minocycline.
34. The method according to claim 25 , further comprising:
an anti-coagulant.
35. The method according to claim 34 , wherein the anti-coagulant is heparin.
36. A catheter kit comprising:
a catheter;
a hydrochloric acid solution having a concentration of 0.3 Molar to 1.0 Molar; and
an antimicrobial agent including 5-Fluorouracil, wherein the 5-Fluorouracil is eluted from the catheter and configured to provide a concentration of 8 ppm to 256 ppm of the 5-Fluorouracil adjacent to a surface of the catheter.
37. The catheter kit according to claim 36 , further comprising:
a syringe configured to mate with a port of the catheter, the syringe including the hydrochloric acid solution.
38. The catheter kit according to claim 36 , further comprising:
a saline solution.
39. The catheter kit according to claim 36 , wherein the hydrochloric acid solution includes a hydrochloric acid concentration of 0.3 Molar to 0.5 Molar.
40. The catheter kit according to claim 36 , wherein the antimicrobial agent includes silver sulfadiazine.
41. The catheter kit according to claim 40 , wherein the silver sulfadiazine is eluted from the catheter and configured to provide a concentration of at least 128 ppm of the silver sulfadiazine adjacent to a surface of the catheter.
42. The catheter kit according to claim 36 , wherein the antimicrobial agent includes Rifampin and Minocycline.
43. The catheter kit according to claim 36 , further comprising:
an anti-coagulant.
44. The catheter kit according to claim 43 , wherein the anti-coagulant is heparin.