Process of making a prosthetic device from electrospun fibers
In accordance with certain embodiments of the present disclosure, a process of forming a prosthetic device is provided. The process includes forming a dispersion of polymeric particles, a fiberizing polymer, and a solvent, the dispersion having a viscosity of at least about 50,000 cPs. A tubular frame is positioned over a tubular polymeric structure. Nanofibers from the dispersion are electrospun onto the tubular frame to form a prosthetic device. The prosthetic device is heated.
1. A process of forming a prosthetic device comprising: forming a dispersion of polymeric particles, a fiberizing polymer, and a solvent, the dispersion having a viscosity of at least about 50,000 cPs; positioning a tubular frame over a tubular polymeric structure; electrospinning nanofibers from the dispersion onto the tubular frame to form a prosthetic device; and heating the prosthetic device.
2. The process of claim 1 , wherein the polymeric particles comprise polytetrafluoroethylene.
3. The process of claim 2 , wherein the dispersion comprises about 50-80 weight percent of polytetrafluoroethylene.
4. The process of claim 1 , further comprising sintering.
5. The process of claim 1 , wherein the solvent comprises water.
6. The process of claim 1 , wherein the fiberizing polymer comprises polyethylene oxide.
7. The process of claim 1 , wherein the tubular polymeric structure comprises expanded polytetrafluoroethylene.
8. A process for forming a prosthetic device comprising: forming a dispersion of polymeric particles, a fiberizing polymer, and a solvent, the dispersion having a viscosity of at least about 50,000 cPs; electrospinning nanofibers from the dispersion onto a tubular polymeric structure; wrapping a layer of polymeric material over the nanofibers and around the tubular polymeric structure to form a prosthetic device; and heating the prosthetic device.
9. The process of claim 8 , wherein the nanofibers comprise polytetrafluoroethylene.
10. The process of claim 9 , wherein the dispersion comprises about 50-80 weight percent of polytetrafluoroethylene.
11. The process of claim 8 , further comprising sintering.
12. The process of claim 8 , wherein the solvent comprises water.
13. The process of claim 8 , wherein the fiberizing polymer comprises polyethylene oxide.
14. The process of claim 8 , wherein the tubular polymeric structure comprises expanded polytetrafluoroethylene.
15. The process of claim 8 , wherein the layer of polymeric material comprises expanded polytetrafluoroethylene.
16. A process of forming a prosthetic device comprising: forming a dispersion of polymeric particles, a fiberizing polymer, and a solvent, the dispersion having a viscosity of at least about 50,000 cPs; positioning a tubular frame over a tubular polymeric structure; electrospinning nanofibers from the dispersion onto the tubular frame; wrapping a layer of polymeric material over the nanofibers and around the tubular frame and tubular polymeric structure to form a prosthetic device; and heating the prosthetic device.
17. The process of claim 16 , wherein the polymeric particles comprise polytetrafluoroethylene.
18. The process of claim 16 , wherein the tubular polymeric structure comprises expanded polytetrafluoroethylene.
19. The process of claim 16 , wherein the layer of polymeric material comprises expanded polytetrafluoroethylene.
20. The process of claim 16 , wherein the fiberizing polymer comprises a polyacrylamide, polyvinyl alcohol, polyvinylpyrrolidone, dextran, alginate, chitosan, guar gum compound, starch, cellulosic compound, polyacrylate, polycarboxylate, polylactic acid, polymethacrylic acid, or combinations thereof.
21. A process of forming a prosthetic device comprising: electrostatically spinning nanofibers from a dispersion onto a tubular frame positioned over a tubular polymeric structure to form a prosthetic device, wherein the dispersion comprises polymeric particles, a fiberizing polymer, and a solvent, the dispersion having a viscosity of at least about 50,000 cPs; and heating the prosthetic device.
22. A process of forming a prosthetic device comprising: electrostatically spinning nanofibers from a dispersion onto a tubular polymeric structure, wherein the dispersion comprises polymeric particles, a fiberizing polymer, and a solvent, the dispersion having a viscosity of at least about 50,000 cPs; wrapping a layer of polymeric material over the nanofibers and around the tubular polymeric structure to form a prosthetic device; and heating the prosthetic device.
23. A process of forming a prosthetic device comprising: electrostatically spinning nanofibers from a dispersion onto a tubular frame positioned over a tubular polymeric structure, wherein the dispersion comprises polymeric particles, a fiberizing polymer, and a solvent, the dispersion having a viscosity of at least about 50,000 cPs; wrapping a layer of polymeric material over the nanofibers and around the tubular frame and tubular polymeric structure to form a prosthetic device; and heating the prosthetic device.