Adhesion promoting temporary mask for coated surfaces
View Patent ↗An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a first diameter to a second diameter. A plurality of different beneficial agents may be loaded into different openings within the struts for delivery to the tissue. For treatment of conditions such as restenosis, different agents are loaded into different openings in the device to address different biological processes involved in restenosis and are delivered at different release kinetics matched to the biological process treated. The different agents may also be used to address different diseases from the same drug delivery device. In addition, anti-thrombotic agents may be affixed to at least a portion of the surfaces of the medical device for the prevention of sub-acute thrombosis. To ensure that the different agents remain affixed to the device as well as to each other, masking and de-masking processes may be utilized.
1. A method of coating an intraluminal scaffold having a plurality of openings therein, the method comprising:
applying a mask to interior surfaces of the plurality of non-interconnected openings in the intraluminal scaffold;
applying a coating to unmasked surfaces of the intraluminal scaffold and to the mask, the coating comprising an anti-thrombotic material;
removing the mask and any coating adhered to the mask from the interior surfaces of the plurality of openings in the intraluminal scaffold while leaving the coating applied to the unmasked surfaces of the intraluminal scaffold; and
filling the plurality of openings with one or more therapeutic agents, wherein the step of applying a mask comprises contacting the interior surfaces of the plurality of openings with a solution of a polymer and a first solvent for at least one time without affecting an interior structure of the intraluminal scaffold.
2. The method of coating an intraluminal scaffold according to claim 1 , wherein the step of applying a coating comprises contacting the surfaces of the intraluminal stent with at least a primer layer for the anti-thrombotic material followed by contacting the primer layer with the anti-thrombotic coating.
3. The method of coating an intraluminal scaffold according to claim 2 , wherein the step of removing the mask comprises contacting the mask with a second solvent and applying ultrasonic energy to the second solvent while in the plurality of openings.
4. The method of coating an intraluminal scaffold according to claim 2 , wherein the step of removing the mask comprises contacting the mask with a second solvent and applying thermal energy to the second solvent while in the plurality of openings.