Methods and compositions for use in treating cancer
The invention provides methods and compositions for use in treating diseases associated with excessive cellular proliferation, such as cancer, and intermediates for the synthesis of such compositions.
1. A compound having the formula:
2. A compound having the formula:
3. A compound having the formula:
4. A compound having the formula:
5. A compound having the formula:
6. A method of preparing:
or a pharmaceutically acceptable salt thereof, the method comprising the steps of
synthesizing a compound selected from the group consisting of
and
synthesizing B1939 or the pharmaceutically acceptable salt from the compound.
7. A method of preparing:
or a pharmaceutically acceptable salt thereof, the method comprising the steps of reacting
under conditions to produce:
reacting ER804029 under conditions to produce:
reacting ER804030 under conditions to produce:
reacting B2304 under conditions to produce:
reacting B2303, B2303 under conditions to produce:
reacting B2301 under conditions to produce:
and
reacting B1793 under conditions to produce B1939 or the pharmaceutically acceptable salt.