Inorganic shaped bodies and methods for their production and use
View Patent ↗Shaped, preferably porous, inorganic bodies are provided which are prepared from a reactive blend. In accordance with one preferred embodiment, the solution is absorbed into a porous sacrificial substrate such as a cellulose sponge. The solution-saturated substrate is heated and an oxidation-reduction reaction occurs thereby forming an inorganic solid. A shaped, inorganic body is formed in situ. Optional, but preferred additional thermal treatment of the shaped, inorganic body removes the organic substrate, leaving an inorganic body that faithfully mimics the porosity, shape, and other physical characteristics of the organic substrate. Inorganic substrates may also be used to good effect. Large varieties of shaped bodies can be prepared in accordance with other embodiments of the invention and such shapes find wide use in surgery, laboratory and industrial processes and otherwise. The invention also provides chemically and morphologically uniform powders, including those having uniformly small sizes.
1. A shaped body for restoring or repairing bone in an animal comprising calcium phosphate and a compound selected from the group consisting of Be, Mg, Sr, Ba, Cr, Mn, Fe, Co, Ni, Cu, Zn, Rh, Pd, Cd, Sn, Hg, and Pb, wherein the shaped body has substantially uniform macroporosity, mesoporosity, and microporosity; and a pore volume of at least about 75%.
2. The shaped body of claim 1 , wherein the compound is Sr.
3. The shaped body of claim 2 , wherein the calcium phosphate is beta-tricalcium phosphate.
4. The shaped body of claim 2 , wherein the calcium phosphate is greater than about 90% β-tricalcium phosphate.
5. The shaped body of claim 2 , wherein the calcium phosphate is greater than about 95% β-tricalcium phosphate.
6. The shaped body of claim 1 wherein the total pore volume is at least about 80%.
7. The shaped body of claim 1 wherein the total pore volume is at least about 90%.
8. The shaped body of claim 1 , wherein approximately 60% to 65% of the pores are macropores.
9. The shaped body of claim 1 , wherein approximately 5% to 15% of the pores are mesopores.
10. The shaped body of claim 1 , wherein approximately 25% to 30% of the pores are micropores.
11. The shaped body of claim 1 , wherein the compound is Zn.