Diaminooxidase-containing pharmaceutical compositions
The present invention relates to pharmaceutical compositions, food supplement compositions and cosmetic compositions comprising diaminooxidase, and to the use thereof.
1. A method of reducing histamine in the gastro-intestinal tract of a person comprising orally administering gastric juice-resistant pellets comprising diaminooxidase to the person, wherein the gastric juice-resistant pellets comprises 10 to 20% gastric-juice resistant coating.
2. The method of claim 1 , wherein the gastric-juice resistant pellets comprise anionic polymers of methacrylic acid and methacrylates, shellac, acetylated starch, or a combination thereof.
3. The method of claim 1 , wherein the gastric-juice resistant pellets comprise microcrystalline cellulose.
4. The method of claim 1 , wherein the gastric-juice resistant pellets have an average diameter of 0.7 to 2 millimeters.
5. The method of claim 1 , wherein the gastric-juice resistant pellets comprise by weight 3% diaminooxidase having an activity of approximately 80,000 U/ml, 40% microcrystalline cellulose, and 20% sucrose, and 15% gastric-juice resistant coating.
6. The method of claim 1 , wherein the diaminooxidase is of non-plant origin.
7. The method of claim 1 , wherein the gastric-juice resistant pellets are administered with food.
8. The method of claim 1 , wherein the person has scombrotoxism.
9. The method of claim 1 , wherein the person has consumed a source of exogenous histamine.
10. The method of claim 9 , wherein the source of exogenous histamine is one or more of cheese, wine, canned fish, or sauerkraut.
11. The method of claim 1 , wherein the person has consumed a diaminooxidase-inhibiting substance.
12. The method of claim 11 , wherein the diaminooxidase-inhibiting substance is alcohol, an amine-rich food, or a diaminooxidase-inhibiting drug.
13. The method of claim 1 , wherein the gastric juice-resistant pellet is capable of protecting an active substance under the action of a gastric juice for at least 10 minutes, wherein the active substance undergoes a loss of activity of no more than 50%.
14. The method of claim 1 , wherein the diaminooxidase has an activity of approximately 80,000 U/ml.
15. The method of claim 1 , wherein the gastric juice-resistant pellets comprises 13 to 17% gastric-juice resistant coating.
16. The method of claim 1 , wherein the gastric juice-resistant pellets comprises 15% gastric-juice resistant coating.